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Promoting Genetic Counseling among African American Women with Hereditary Risk for Breast Cancer

促进有乳腺癌遗传风险的非裔美国女性的遗传咨询

基本信息

批准号：
10166807
负责人：
Vida Ann Henderson
金额：
$ 16.07万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10166807
关键词：
Address Advisory Committees Affect African American Applications Grants Award Awareness BRCA1 gene Behavioral Behavioral Model Breast Cancer Risk Factor Cancer Center Chicago Clinical Research Counseling Coupled DNA Sequence Alteration Data Decision Aid Decision Making Development Development Plans Diffusion Discipline Distress Early Diagnosis Educational workshop Ensure Epigenetic Process Family member Federally Qualified Health Center Funding General Population Genes Genetic Genetic Counseling Genetic Services Goals Grant Guidelines High Risk Woman Illinois Individual Inherited Intervention Knowledge Lead Malignant Neoplasms Mentors Mentorship Methods Minority Mission Multimedia Neighborhood Health Center Not Hispanic or Latino Pamphlets Participant Pathogenicity Pathway Analysis Physicians Population Heterogeneity Positioning Attribute Preventive service Primary Health Care Productivity Provider Psychosocial Factor Public Health Public Health Schools Randomized Controlled Trials Recommendation Research Research Activity Research Personnel Risk Scientist Self Determination Services Social Network Structure Testing Time Training Training Activity Translational Research United States Universities Variant Woman Work Writing cancer genetics cancer health disparity cancer prevention career career development cost design effectiveness testing emotional distress ethnic minority population genetic risk assessment genetic testing health service use hereditary risk high risk high risk population hormone receptor-negative improved intrinsic motivation malignant breast neoplasm meetings minority communities mortality multidisciplinary precision medicine racial and ethnic risk perception skills social social relationships socioeconomics tool tumor underserved minority uptake

项目摘要

1 The long-term career goal of this K01 project is to gain training and mentorship that will prepare me for a career 2 as an independent and successful externally funded investigator in the field of cancer health disparities. Over 3 the next 5 years, my career objectives are to: 1) develop and lead experimental interventions; 2) gain further 4 expertise in translational science; 3) acquire skills in quantitative analysis, including social network analysis; and 5 4) enhance my ability to write competitive grant applications and increase my scholarly productivity. With my 6 primary mentor, Dr. Marian Fitzgibbon, I have assembled a strong team of co-mentors and advisors (including a 7 biostatistician) to guide me through the proposed training and research activities. The proposed career 8 development plan is structured to ensure that I achieve training milestones through didactic coursework, career 9 development workshops, and attendance at national scientific meetings. The University of Illinois at Chicago 10 (School of Public Health and Cancer Center) are committed to supporting my career development and providing 11 the protected time needed to achieve my career and research goals. The overall objective of this K01 research 12 project is to test the effectiveness of a culturally targeted video, previously developed by our research team, on 13 promoting genetic counseling attendance among African American (AA) women determined to be at high risk for 14 breast cancer through cancer genetic risk assessment at a Federally Qualified Health Center. Uptake of genetic 15 services is particularly low among high-risk AA women, who carry a disproportionate burden of breast cancer 16 mortality. Further, although testing close relatives of individuals who test positive for a pathogenic variant might 17 curtail breast cancer disparities attributable to hereditary risk, it is unclear how counseled or tested individuals 18 influence their social and familial networks. Thus, my central hypothesis is that the culturally targeted video will 19 increase genetic counseling attendance among participants compared to those who receive a genetic counseling 20 brochure. The proposed Specific Aims are to: 1) compare the effects of the video and brochure on genetic 21 counseling attendance among AA women at high risk for breast cancer; 2) test how psychosocial factors 22 (knowledge, intrinsic motivation, risk perception, distress) affect relationships between intervention exposures 23 (video/brochure) and genetic counseling attendance; and 3) compare the impact of intervention exposures 24 (video/brochure) on diffusion of knowledge through social network analysis. My prior training, coupled with the 25 skills that I will acquire during the award period, will equip me to successfully conduct the proposed research 26 and position me to continue my work to address breast cancer disparities that persist among high-risk AA women. 27 28 29 30 31 32

这个K01项目的长期职业目标是获得培训和指导，为我的职业生涯做准备