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Promoting Genetic Counseling among African American Women with Hereditary Risk for Breast Cancer

促进有乳腺癌遗传风险的非裔美国女性的遗传咨询

基本信息

批准号：
10506796
负责人：
Vida Ann Henderson
金额：
$ 16.17万
依托单位：
FRED HUTCHINSON CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-10-16 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10506796
关键词：
Address Advisory Committees Affect African American Applications Grants Award Awareness BRCA1 gene Behavioral Behavioral Model Breast Cancer Risk Factor Cancer Center Chicago Clinical Research Counseling Coupled DNA Sequence Alteration Data Decision Aid Decision Making Development Development Plans Diffusion Discipline Distress Early Diagnosis Educational workshop Ensure Epigenetic Process Family member Federally Qualified Health Center Funding General Population Genes Genetic Genetic Counseling Genetic Services Goals Grant Guidelines High Risk Woman Illinois Individual Inherited Intervention Knowledge Lead Malignant Neoplasms Mentors Mentorship Methods Minority Women Mission Multimedia Neighborhood Health Center Not Hispanic or Latino Pamphlets Participant Pathogenicity Pathway Analysis Physicians Population Heterogeneity Positioning Attribute Preventive service Primary Health Care Productivity Provider Psychosocial Factor Public Health Public Health Schools Randomized Controlled Trials Recommendation Research Research Activity Research Personnel Risk Scientist Self Determination Services Social Network Structure Testing Time Training Training Activity Translational Research United States Universities Variant Woman Work Writing cancer genetics cancer health disparity cancer prevention career career development cost design effectiveness testing emotional distress ethnic minority genetic risk assessment genetic testing health service use hereditary risk high risk high risk population hormone receptor-negative improved intrinsic motivation malignant breast neoplasm meetings minority communities mortality multidisciplinary precision medicine racial and ethnic risk perception skills social social relationships socioeconomics tool tumor underserved minority uptake video coaching

项目摘要

1 The long-term career goal of this K01 project is to gain training and mentorship that will prepare me for a career 2 as an independent and successful externally funded investigator in the field of cancer health disparities. Over 3 the next 5 years, my career objectives are to: 1) develop and lead experimental interventions; 2) gain further 4 expertise in translational science; 3) acquire skills in quantitative analysis, including social network analysis; and 5 4) enhance my ability to write competitive grant applications and increase my scholarly productivity. With my 6 primary mentor, Dr. Marian Fitzgibbon, I have assembled a strong team of co-mentors and advisors (including a 7 biostatistician) to guide me through the proposed training and research activities. The proposed career 8 development plan is structured to ensure that I achieve training milestones through didactic coursework, career 9 development workshops, and attendance at national scientific meetings. The University of Illinois at Chicago 10 (School of Public Health and Cancer Center) are committed to supporting my career development and providing 11 the protected time needed to achieve my career and research goals. The overall objective of this K01 research 12 project is to test the effectiveness of a culturally targeted video, previously developed by our research team, on 13 promoting genetic counseling attendance among African American (AA) women determined to be at high risk for 14 breast cancer through cancer genetic risk assessment at a Federally Qualified Health Center. Uptake of genetic 15 services is particularly low among high-risk AA women, who carry a disproportionate burden of breast cancer 16 mortality. Further, although testing close relatives of individuals who test positive for a pathogenic variant might 17 curtail breast cancer disparities attributable to hereditary risk, it is unclear how counseled or tested individuals 18 influence their social and familial networks. Thus, my central hypothesis is that the culturally targeted video will 19 increase genetic counseling attendance among participants compared to those who receive a genetic counseling 20 brochure. The proposed Specific Aims are to: 1) compare the effects of the video and brochure on genetic 21 counseling attendance among AA women at high risk for breast cancer; 2) test how psychosocial factors 22 (knowledge, intrinsic motivation, risk perception, distress) affect relationships between intervention exposures 23 (video/brochure) and genetic counseling attendance; and 3) compare the impact of intervention exposures 24 (video/brochure) on diffusion of knowledge through social network analysis. My prior training, coupled with the 25 skills that I will acquire during the award period, will equip me to successfully conduct the proposed research 26 and position me to continue my work to address breast cancer disparities that persist among high-risk AA women. 27 28 29 30 31 32

1这个K01项目的长期职业目标是获得培训和指导，为我的职业生涯做好准备 2作为在癌症健康差距领域的独立和成功的外部资助的调查者。完毕 3在接下来的5年里，我的职业目标是：1)开发和领导实验性干预措施；2)进一步获得 4)翻译科学方面的专业知识；3)掌握定量分析的技能，包括社会网络分析；以及 5)增强我撰写有竞争力的拨款申请的能力，提高我的学术生产力。带着我的 6首席导师玛丽安·菲茨吉本博士，我已经组建了一支强大的联合导师和顾问团队(包括 7生物统计学家)指导我完成拟议的培训和研究活动。计划中的职业 8发展计划是结构化的，以确保我通过教学课程、职业生涯达到培训里程碑 9个发展讲习班和出席国家科学会议。伊利诺伊大学芝加哥分校 10(公共卫生学院和癌症中心)致力于支持我的职业发展并提供 11实现我的职业和研究目标所需的保障时间。本次K01研究的总体目标是 12项目是测试一段具有文化针对性的视频的有效性，该视频之前由我们的研究团队开发， 13促进非洲裔美国人(AA)妇女参加遗传咨询，这些妇女被确定为糖尿病的高危人群 14在联邦合格的健康中心通过癌症遗传风险评估。对基因的吸收 15服务在高风险再生障碍性贫血妇女中尤其低，她们承担着不成比例的乳腺癌负担 16人死亡。此外，尽管检测出致病变种呈阳性的个人的近亲可能 17可归因于遗传风险的乳腺癌差异，尚不清楚接受咨询或测试的个体 18影响他们的社会和家庭网络。因此，我的中心假设是，具有文化针对性的视频将 19与接受遗传咨询的人相比，参与者的遗传咨询出勤率更高 20本小册子。建议的具体目的是：1)比较视频和宣传册对基因的影响 21在乳腺癌高危AA女性中进行咨询；2)测试心理社会因素 22(知识、内在动机、风险感知、痛苦)影响干预暴露之间的关系 23(视频/小册子)和遗传咨询出席；以及3)比较干预暴露的影响 24关于通过社会网络分析传播知识的视频/小册子。我之前的训练，再加上我将在获奖期间获得的25项技能，将使我能够成功地进行拟议的研究 26并让我继续我的工作，解决在AA高危女性中持续存在的乳腺癌差异。 27 28 29 30 31 32