Development of Amygdalo-Prefrontal Connections in Adolescent Macaques

青春期猕猴杏仁核-前额叶连接的发展

• 批准号: 10165833
• 负责人: Katalin M Gothard
• 金额: $ 23.03万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10165833
• 关键词: Adolescence; Adolescent; Adolescent Development; Adult; Amygdaloid structure; Anatomy; Anxiety; Area; Arizona; Arousal; Behavior; Behavior assessment; Behavioral; Brain; China; Cognitive; Coupled; Data; Development; Disease; Distant; Emotional; Equilibrium; Feedback; Foundations; Functional Magnetic Resonance Imaging; Goals; Growth; Human; Image; Impulse Control Disorders; Impulsivity; Individual; Institutes; International; Lasers; Longitudinal Studies; Macaca; Magnetic Resonance Imaging; Maps; Measures; Mental disorders; Methods; Monitor; Monkeys; Neurons; Optics; Pattern; Physiologic pulse; Physiological; Prefrontal Cortex; Process; Psyche structure; Puberty; Regulation; Research; Resolution; Rewards; Risk; Risk Factors; Scientist; Site; Social Behavior; Social Development; Stimulus; Structure; Technology; Time; Universities; Virus; Vision; adolescent brain development; behavior measurement; cognitive development; cognitive process; cognitive skill; design; early adolescence; emotion regulation; emotional behavior; experimental study; in vivo; millimeter; multimodality; neurophysiology; neurotechnology; new technology; nonhuman primate; novel; relating to nervous system; response; skills; social; social cognition; social skills

PROJECT SUMMARY/ABSTRACT This project combines the expertise of Dr. Katalin Gothard at The University of Arizona [US] and Dr. Anna W. Roe at Zhejiang University [China]. The aim of this project is to understand changes in the brain underlying the emergence of social and emotional regulation during adolescence. Adolescence is a period of accelerated social and cognitive development, and also a time of enhanced vulnerability for anxiety and impulse-control disorders, which elevate the lifelong risk for secondary psychiatric disorders. During this period, the prefrontal cortex undergoes maturation, but little is known about the maturation of its relationship with the amygdala, considered a hub of emotional processing in the brain. In humans and nonhuman primates, the amygdala matures long before puberty; in early adolescence, emotional processes and arousal governed by the amygdala dominate emotional and social behavior. As the prefrontal cortex matures and increases its influence on amygdalar function, emotional behavior becomes more regulated. We hypothesize that the development of emotional regulation during adolescence is due to changes in amygdala-prefrontal networks. The goal of this proposal is to monitor longitudinally, in the same individuals, the reorganization of functional connections between the amygdala and the PFC. This will be accomplished by a multimodal approach of laser-fMRI functional tract tracing, and neurophysiological recordings in the amygdala and the prefrontal cortex. In parallel, punctate administration of behavioral tasks will provide a measure of longitudinal changes in impulsivity and sociability. The fMRI, neurophysiological, and behavioral measures will be correlated at matched timepoints, thereby achieving a multiscale (cellular to circuit level to behavior) understanding of adolescent development. The findings from this study will have significant bearing on our understanding of normal adolescent brain development and also of the possible risk factors for the emergence of social misadjustment and mental disease.

项目概要/摘要 该项目结合了美国亚利桑那大学 Katalin Gothard 博士和 Anna W. 罗伊，浙江大学[中国]。该项目的目的是了解大脑的变化 青春期社会和情绪调节的出现。青春期是社会交往加速的时期 和认知发展，也是一个更容易出现焦虑和冲动控制障碍的时期， 这会增加继发性精神疾病的终生风险。在此期间，前额皮质 经历成熟，但人们对其与杏仁核的关系的成熟知之甚少，认为 大脑中情绪处理的枢纽。在人类和非人类灵长类动物中，杏仁核成熟时间较长 青春期之前；在青春期早期，由杏仁核控制的情绪过程和唤醒占主导地位 情感和社会行为。随着前额皮质的成熟并增加其对杏仁核的影响 功能、情绪行为变得更加规范。我们假设情绪的发展 青春期的调节是由于杏仁核-前额叶网络的变化造成的。该提案的目标是 纵向监测同一个体之间功能联系的重组 杏仁核和前额皮质。这将通过激光功能磁共振功能束追踪的多模式方法来实现， 以及杏仁核和前额皮质的神经生理学记录。同时，点状给药 行为任务将提供冲动性和社交性纵向变化的衡量标准。功能磁共振成像， 神经生理学和行为测量将在匹配的时间点相关联，从而实现 对青少年发展的多尺度（细胞到电路水平到行为）理解。由此得出的结论 研究将对我们对正常青少年大脑发育以及对青少年大脑发育的理解产生重大影响。 出现社会失调和精神疾病的可能危险因素。