Development of Amygdalo-Prefrontal Connections in Adolescent Macaques

青春期猕猴杏仁核-前额叶连接的发展

基本信息

批准号：
10165833
负责人：
Katalin M Gothard
金额：
$ 23.03万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10165833
关键词：
Adolescence Adolescent Adolescent Development Adult Amygdaloid structure Anatomy Anxiety Area Arizona Arousal Behavior Behavior assessment Behavioral Brain China Cognitive Coupled Data Development Disease Distant Emotional Equilibrium Feedback Foundations Functional Magnetic Resonance Imaging Goals Growth Human Image Impulse Control Disorders Impulsivity Individual Institutes International Lasers Longitudinal Studies Macaca Magnetic Resonance Imaging Maps Measures Mental disorders Methods Monitor Monkeys Neurons Optics Pattern Physiologic pulse Physiological Prefrontal Cortex Process Psyche structure Puberty Regulation Research Resolution Rewards Risk Risk Factors Scientist Site Social Behavior Social Development Stimulus Structure Technology Time Universities Virus Vision adolescent brain development behavior measurement cognitive development cognitive process cognitive skill design early adolescence emotion regulation emotional behavior experimental study in vivo millimeter multimodality neurophysiology neurotechnology new technology nonhuman primate novel relating to nervous system response skills social social cognition social skills

项目摘要

PROJECT SUMMARY/ABSTRACT This project combines the expertise of Dr. Katalin Gothard at The University of Arizona [US] and Dr. Anna W. Roe at Zhejiang University [China]. The aim of this project is to understand changes in the brain underlying the emergence of social and emotional regulation during adolescence. Adolescence is a period of accelerated social and cognitive development, and also a time of enhanced vulnerability for anxiety and impulse-control disorders, which elevate the lifelong risk for secondary psychiatric disorders. During this period, the prefrontal cortex undergoes maturation, but little is known about the maturation of its relationship with the amygdala, considered a hub of emotional processing in the brain. In humans and nonhuman primates, the amygdala matures long before puberty; in early adolescence, emotional processes and arousal governed by the amygdala dominate emotional and social behavior. As the prefrontal cortex matures and increases its influence on amygdalar function, emotional behavior becomes more regulated. We hypothesize that the development of emotional regulation during adolescence is due to changes in amygdala-prefrontal networks. The goal of this proposal is to monitor longitudinally, in the same individuals, the reorganization of functional connections between the amygdala and the PFC. This will be accomplished by a multimodal approach of laser-fMRI functional tract tracing, and neurophysiological recordings in the amygdala and the prefrontal cortex. In parallel, punctate administration of behavioral tasks will provide a measure of longitudinal changes in impulsivity and sociability. The fMRI, neurophysiological, and behavioral measures will be correlated at matched timepoints, thereby achieving a multiscale (cellular to circuit level to behavior) understanding of adolescent development. The findings from this study will have significant bearing on our understanding of normal adolescent brain development and also of the possible risk factors for the emergence of social misadjustment and mental disease.

项目摘要/摘要该项目结合了亚利桑那大学的Katalin Gothard博士的专业知识和Anna W. Anna W. 郑大学的ROE [中国]。该项目的目的是了解大脑的变化青春期社会和情感调节的出现。青春期是一个加速社会的时期和认知发展，也是增加焦虑和冲动控制障碍脆弱性的时期这提高了继发性精神疾病的终身风险。在此期间，前额叶皮层经历成熟，但对其与杏仁核的关系的成熟知之甚少大脑中情感处理的枢纽。在人类和非人类灵长类动物中，杏仁核成熟青春期之前；在青春期的早期，情绪过程和由杏仁核统治的唤醒占主导地位情感和社会行为。随着前额叶皮层的成熟并增加了对杏仁核的影响功能，情绪行为变得更加受调节。我们假设情感的发展青春期的调节是由于杏仁核 - 前额叶网络的变化所致。该提议的目的是为了纵向监视相同的个体，重组功能连接杏仁核和PFC。这将通过激光-FMRI函数式跟踪的多模式方法来实现，以及杏仁核和前额叶皮层中的神经生理记录。同时，点状给药行为任务的措施将提供冲动和社交性纵向变化的量度。 fMRI，神经生理学和行为措施将在匹配的时间点相关，从而实现对青少年发展的多尺度（蜂窝到电路水平到行为）的理解。从中的发现研究将与我们对正常青少年大脑发育的理解以及对社会疾病和精神疾病出现的可能风险因素。