Role of OT and Ach in enhancing social discrimination by modulating primate amygdalo-striatal networks
OT 和 Ach 通过调节灵长类杏仁核纹状体网络增强社会歧视的作用
基本信息
- 批准号:10090656
- 负责人:
- 金额:$ 31.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-01 至 2023-01-31
- 项目状态:已结题
- 来源:
- 关键词:Amygdaloid structureAnimalsAttentionBasal Nucleus of MeynertBehaviorBehavioralBrainCharacteristicsCholinergic AgonistsCholinergic AntagonistsCommunicationCorpus striatum structureCoupledCouplingDataDiscriminationEyeFaceFrequenciesGoalsHumanImageImpairmentIndividualIndividuationInfusion proceduresInjectionsLearningLifeLinkMacacaMeasuresMediatingMemoryMental disordersMessenger RNAMicroinjectionsModalityModelingMonkeysMotivationNeuronsNeurotransmittersNoiseNucleus AccumbensOperant ConditioningOutcomeOutputOxytocinOxytocin ReceptorPerformancePharmacologyPhasePopulationPrefrontal CortexPrimatesProcessRattusResearch DesignResearch Domain CriteriaRewardsRodentRoleSensoryShapesSignal TransductionSocial BehaviorSocial ConditionsSocial DiscriminationStimulusSystemTestingVentral StriatumVisualWorkadverse outcomeautism spectrum disorderbasecholinergiccholinergic neurondesignexperimental studyneuromechanismneurophysiologynonhuman primaterecruitrelating to nervous systemresponsesensory stimulussocialsocial cognitionsocial learningsynergism
项目摘要
PROJECT SUMMARY (Project 4, Gothard)
Despite the great diversity of species-specific social behaviors, many of the fundamental building blocks of social
behavior are shared across species. For example, correct identification of individuals allows animals to learn
the unique rewards or adverse outcomes expected from interacting with different individuals. The sensory
modalities involved in discriminating between individuals may be different across species, but the neural
mechanisms of social discrimination may be shared. Oxytocin (OT) emerged recently as a universal factor that
governs social behaviors in multiple mammalian species. In this project, we explore the role of OT in shaping
basic neural processes during social learning in non-human primates, such as the discrimination of individuals
and the associations of individuals with different levels of reward. The experiments converge on the central
hypothesis that during social learning, OT enhances the functional coupling between the basolateral amygdala
(BLA) and nucleus accumbens (NAc). Consequently, neurons in the BLA are expected to show greater selectivity
for unique combinations of individuals and rewards, while the neural activity across populations of neurons in
the amygdalo-striatal networks are expected to show higher oscillatory coherence. To test these hypotheses we
designed a conditioned social discrimination task that takes advantage of the visual abilities of macaques to
discriminate between individuals presented in videos. This approximates the ability of humans to become highly
familiar and accurately predict the behaviors of individuals even without real-life interactions, a process that is
impaired in many psychiatric disorders, including autism. As this reward-driven task has both perceptual and
operant components, it is expected to involve activation of and communication between the BLA and NAc. The
task, therefore, will generate brain states that are conducive to capture the neural signature of interactions in the
amygdalo-striatal networks. We will measure and compare both single unit activity and local field potential in the
BLA and NAc while monkeys perform the task after local BLA infusion of OT or vehicle. In the primates, OT
receptors (OXTR) are synthesized in the nucleus basalis of Meynert (NBM), not in the BLA. This inspired our
secondary hypothesis that the neurophysiological effects of OT in the BLA are mediated by cholinergic (Ach)
mechanisms. The mechanisms are driven by OXTR signaling on NBM neurons that project to the BLA. The ACh
system enhances learning and memory across species and we hypothesize that during social learning, OT
amplifies ACh release in the BLA, thereby increasing salience of social stimuli. The precise contribution and the
synergy between the OT and Ach systems in the BLA will be tested by neurophysiological recordings coupled
with direct injections of OT and cholinergic agonist/antagonists into the BLA or NBM. This project is highly
integrated with the rodent studies in Project 3, which investigates OT/ACh interactions in social discrimination
conditioned by extrinsic reward by simultaneous recordings of local field potentials and units in the BLA and NAc
of rats.
项目总结(Gothard项目4)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Katalin M Gothard其他文献
Eye contact, a fundamental building block of social behavior, engages single unit activity in the monkey amygdala
- DOI:
10.1186/1471-2202-13-s1-p131 - 发表时间:
2012-07-16 - 期刊:
- 影响因子:2.300
- 作者:
Clayton P Mosher;Prisca E Zimmerman;Katalin M Gothard - 通讯作者:
Katalin M Gothard
Katalin M Gothard的其他文献
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{{ truncateString('Katalin M Gothard', 18)}}的其他基金
Development of Amygdalo-Prefrontal Connections in Adolescent Macaques
青春期猕猴杏仁核-前额叶连接的发展
- 批准号:
10165833 - 财政年份:2020
- 资助金额:
$ 31.39万 - 项目类别:
Development of Amygdalo-Prefrontal Connections in Adolescent Macaques
青春期猕猴杏仁核-前额叶连接的发展
- 批准号:
10579969 - 财政年份:2020
- 资助金额:
$ 31.39万 - 项目类别:
Development of Amygdalo-Prefrontal Connections in Adolescent Macaques
青春期猕猴杏仁核-前额叶连接的发展
- 批准号:
10366029 - 财政年份:2020
- 资助金额:
$ 31.39万 - 项目类别:
The Role of the Primate Amygdala in Social and Affective Touch
灵长类动物杏仁核在社交和情感接触中的作用
- 批准号:
10412986 - 财政年份:2019
- 资助金额:
$ 31.39万 - 项目类别:
The Role of the Primate Amygdala in Social and Affective Touch
灵长类动物杏仁核在社交和情感接触中的作用
- 批准号:
10178114 - 财政年份:2019
- 资助金额:
$ 31.39万 - 项目类别:
THE ROLE OF THE PRIMATE AMYGDALA IN GAZE FOLLOWING AND FACIAL MIMICRY
灵长类杏仁核在目光跟随和面部模仿中的作用
- 批准号:
8432429 - 财政年份:2012
- 资助金额:
$ 31.39万 - 项目类别:
THE ROLE OF THE PRIMATE AMYGDALA IN GAZE FOLLOWING AND FACIAL MIMICRY
灵长类杏仁核在目光跟随和面部模仿中的作用
- 批准号:
8283584 - 财政年份:2012
- 资助金额:
$ 31.39万 - 项目类别:
The primate amygdala and the control of visual search of emotional stimuli
灵长类动物杏仁核和情绪刺激视觉搜索的控制
- 批准号:
7990152 - 财政年份:2010
- 资助金额:
$ 31.39万 - 项目类别:
The primate amygdala and the control of visual search of emotional stimuli
灵长类动物杏仁核和情绪刺激视觉搜索的控制
- 批准号:
8117161 - 财政年份:2010
- 资助金额:
$ 31.39万 - 项目类别:
DIFFERENTIAL ENCODING OF FACIAL EXPRESSIONS IN THE PRIMATE AMYGDALA
灵长类杏仁核面部表情的差异编码
- 批准号:
7349699 - 财政年份:2006
- 资助金额:
$ 31.39万 - 项目类别:
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