Development of Amygdalo-Prefrontal Connections in Adolescent Macaques

青春期猕猴杏仁核-前额叶连接的发展

• 批准号: 10366029
• 负责人: Katalin M Gothard
• 金额: $ 23.03万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10366029
• 关键词: Adolescence; Adolescent; Adolescent Development; Adult; Amygdaloid structure; Anatomy; Anxiety; Area; Arizona; Arousal; Behavior; Behavior assessment; Behavioral; Brain; China; Cognitive; Coupled; Data; Development; Disease; Distant; Emotional; Equilibrium; Feedback; Foundations; Functional Magnetic Resonance Imaging; Goals; Growth; Human; Image; Impulse Control Disorders; Impulsivity; Individual; Institutes; International; Lasers; Longitudinal Studies; Macaca; Magnetic Resonance Imaging; Maps; Measures; Mental disorders; Methods; Monitor; Monkeys; Neurons; Optics; Pattern; Physiologic pulse; Physiological; Prefrontal Cortex; Process; Psyche structure; Puberty; Regulation; Research; Resolution; Rewards; Risk; Risk Factors; Scientist; Site; Social Behavior; Social Development; Stimulus; Technology; Time; Universities; Virus; Vision; adolescent brain development; behavior measurement; cognitive development; cognitive process; cognitive skill; design; early adolescence; emotion regulation; emotional behavior; experimental study; in vivo; millimeter; multimodality; neurophysiology; neurotechnology; new technology; nonhuman primate; novel; relating to nervous system; response; skills; social; social cognition; social skills

PROJECT SUMMARY/ABSTRACT This project combines the expertise of Dr. Katalin Gothard at The University of Arizona [US] and Dr. Anna W. Roe at Zhejiang University [China]. The aim of this project is to understand changes in the brain underlying the emergence of social and emotional regulation during adolescence. Adolescence is a period of accelerated social and cognitive development, and also a time of enhanced vulnerability for anxiety and impulse-control disorders, which elevate the lifelong risk for secondary psychiatric disorders. During this period, the prefrontal cortex undergoes maturation, but little is known about the maturation of its relationship with the amygdala, considered a hub of emotional processing in the brain. In humans and nonhuman primates, the amygdala matures long before puberty; in early adolescence, emotional processes and arousal governed by the amygdala dominate emotional and social behavior. As the prefrontal cortex matures and increases its influence on amygdalar function, emotional behavior becomes more regulated. We hypothesize that the development of emotional regulation during adolescence is due to changes in amygdala-prefrontal networks. The goal of this proposal is to monitor longitudinally, in the same individuals, the reorganization of functional connections between the amygdala and the PFC. This will be accomplished by a multimodal approach of laser-fMRI functional tract tracing, and neurophysiological recordings in the amygdala and the prefrontal cortex. In parallel, punctate administration of behavioral tasks will provide a measure of longitudinal changes in impulsivity and sociability. The fMRI, neurophysiological, and behavioral measures will be correlated at matched timepoints, thereby achieving a multiscale (cellular to circuit level to behavior) understanding of adolescent development. The findings from this study will have significant bearing on our understanding of normal adolescent brain development and also of the possible risk factors for the emergence of social misadjustment and mental disease.

项目总结/文摘