The NYU Women's Health Study

项目总结/摘要 纽约大学妇女健康研究（NYUWHS）是一项前瞻性队列研究，共有14，274名健康妇女参加， 1985-1991年入学。除了生殖因素、病史和生活方式的数据外， 在入组时收集所有参与者的血清样本。血清样本也收集在随后的 超过一半的妇女接受了乳腺癌筛查。DNA可用于所有研究参与者。的 纽约大学妇女卫生研究所发起或参与了乳腺癌、子宫内膜癌、卵巢癌、结肠直肠癌、肺癌、 胰腺、肾、肝、脑和非霍奇金淋巴瘤（NHL）。研究的暴露包括饮食、生殖 因子和激素、饮食标志物、细胞因子和其他生物标志物的循环水平。 这项研究的总体目标是了解癌症的病因，并提供可能导致癌症的信息。 预防本应用程序的目标是维护和增强研究的基础设施， 未来五年具体目标是：1）继续查明癌症病例; 2）继续维持 复杂的数据库; 3）继续维持血液样品（血清，细胞沉淀物， 和血栓）和肿瘤组织; 4）通过维持研究促进合作和数据共享 网站并及时响应请求; 5）继续收集主要癌症部位（乳腺， 结直肠癌、子宫内膜癌和肺癌），对于乳腺癌，构建肿瘤微阵列用于分类， 分子亚型; 6）通过从大约3，400名患者中收集粪便样本来扩大生物储存库 7）评估新的潜在癌症生物标志物的长期可重复性。截至2016年1月1日，5，047人 已经确定了癌症事件，预计继续随访将确定另外1，277例 癌症病例（总数= 5 989）。 纽约大学妇女卫生研究所的具体优势包括：1）长期随访：纽约大学妇女卫生研究所的参与者被跟踪- 最多27至33年，因此，随着时间的推移，风险因素的变化对癌症风险的影响可能 接受检查。2)在入组时收集的血清和DNA可供所有参与者使用， 生物储存库是研究遗传变异、生物标志物和癌症风险之间关系的宝贵资源; 3)可用于评估循环标志物时间可靠性的重复血清样本， 超过一半的参与者可用; 4）虽然大多数大型癌症流行病学队列开始 在50岁时入学，6，659名NYUWHS参与者（47%）年龄在35岁至49岁之间， 入组/献血，为研究风险因素和生物标志物提供了机会， 年轻女性

PROJECT SUMMARY/ABSTRACT The NYU Women’s Health Study (NYUWHS) is a prospective cohort study of 14,274 healthy women who were enrolled in 1985-1991. In addition to data on reproductive factors, medical history and lifestyle, the study collected serum samples from all participants at enrollment. Serum samples were also collected at subsequent breast cancer screening visits from over half the women. DNA is available for all study participants. The NYUWHS has initiated or participated in studies of cancer of the breast, endometrium, ovary, colorectum, lung, pancreas, kidney, liver, brain, and non-Hodgkin lymphoma (NHL). Exposures studied include diet, reproductive factors, and circulating levels of hormones, dietary markers, cytokines, and other biomarkers. The overall goal of the study is to understand the etiology of cancer and provide information that can lead to prevention. The objectives of this application are to maintain and enhance the infrastructure of the study over the next five years. The specific aims are to: 1) Continue cancer case ascertainment; 2) Continue to maintain the complex database; 3) Continue to maintain the biorepository of blood samples (serum, cell precipitates, and clots) and tumor tissues; 4) Facilitate collaborations and data sharing through maintenance of the study website and timely response to requests; 5) Continue tumor tissue collection for major cancer sites (breast, colorectal, endometrial, and lung) and, for breast cancer, construction of tumor microarrays for classification in molecular subtypes; 6) Expand the biorepository by collecting a stool sample from approximately 3,400 women; 7) Assess the long-term reproducibility of new potential cancer biomarkers. As of 1/1/2016, 5,047 incident cancers have been identified and the continued follow-up is expected to identify an additional 1,277 cancer cases (total = 5989). The specific strengths of the NYUWHS include: 1) Long follow-up: NYUWHS participants have been followed- up for 27 to 33 years, and the impact of changes in risk factors over time in relation to cancer risk can therefore be examined. 2) Serum collected at enrollment and DNA are available for all participants, making the biorepository a valuable resource to study associations between genetic variation, biomarkers, and cancer risk; 3) Repeat serum samples, which can be used to assess temporal reliability of circulating markers, are available for over half of the participants; 4) While the majority of large Cancer Epidemiology Cohorts started enrollment at age 50, 6,659 NYUWHS participants (47%) were between the ages of 35 and 49 at enrollment/blood donation, providing opportunities for the study of risk factors and biomarkers measured in younger women.