Integration of Electrophysiological and Behavioral Economic Models of Reward Among Heavy Drinking Emerging Adults

重度饮酒的新兴成年人奖励的电生理学和行为经济学模型的整合

• 批准号: 10172803
• 负责人: Samuel Fisher Acuff
• 金额: $ 3.68万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-05 至 2022-06-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10172803
• 关键词: Accidents; Acute; Alcohol consumption; Alcohols; Appointment; Award; Behavioral; Biological; Biological Markers; Cessation of life; Chronic; Clinical; Cognitive; Cues; Data; Data Analyses; Development; Diagnosis; Disease; Economic Models; Electroencephalogram; Electrophysiology (science); Elements; Event-Related Potentials; Feedback; Funding; Future; Gambling; Goals; Health; Heavy Drinking; Image; Individual; Intervention; Investigation; Lead; Learning; Legal; Link; Longitudinal Studies; Measures; National Institute on Alcohol Abuse and Alcoholism; National Research Service Awards; Outcome; Parents; Participant; Pathology; Pathway interactions; Patient Self-Report; Pattern; Population; Psychological reinforcement; Public Health; Reporting; Rewards; Risk; Stimulus; Strategic Planning; Stress; Time; Training; age group; alcohol cue; alcohol demand; alcohol free; alcohol measurement; alcohol misuse; alcohol related problem; alcohol use disorder; behavior test; behavioral economics; binge drinker; biobehavior; career; cohort; contextual factors; craving; discounting; drinking; drug misuse; emerging adult; follow-up; improved; incentive salience; indexing; millisecond; neuroeconomics; neurophysiology; pre-doctoral; preference; prospective; psychologic; recruit; response; reward processing; social; temporal measurement; theories; therapy development; vehicular accident

7. Project Summary/Abstract Alcohol misuse among emerging adults (age 18-25) is a major public health concern that results in acute and chronic consequences, such as blackouts, motor vehicle accidents, poorer career outcomes, disease, and death. Although many individuals “mature out” of heavy drinking, the determinants of positive drinking trajectories are unknown. Further, longitudinal studies examining these determinants often do not include biological indicators, inherently creating a gap between neuroscientific and clinical inquiries into alcohol misuse. Thus, as an adjunct study to an already funded longitudinal R01 (R01AA024930-01; Multiple PIs MacKillop & Murphy), we will recruit heavy drinking emerging adults (N = 95) at their 8-month follow-up appointment to engage in a single electroencephalogram (EEG) session measuring two event-related potential components that theoretically represent reward processing. Participants will then continue participation in the parent R01 and will complete follow-up self-report sessions at 12- and 16-months. Data collected from the EEG session will be used to predict changes in alcohol misuse (alcohol consumption, alcohol-related problems, and alcohol use disorder) at the 4- and 8-month follow-ups (i.e., the 12 and 16-month parent study follow-ups). The aims of the proposed project are: 1) to integrate electrophysiological indices (P3 and RewP) of alcohol, nonalcohol, immediate, and delayed reward into the ongoing longitudinal study to compare with self-report behavioral economic variables already included (i.e., alcohol demand, delayed discounting, substance-related relative to substance-free reinforcement); and 2) to explore prospective relations between event-related potentials, behavioral economic variables, and alcohol misuse. The study employs two paradigms for eliciting event-related potentials of reward processing: 1) oddball task (repetitive “common” stimulus presentation with dispersed “uncommon” images, for eliciting reactivity during uncommon images) for both nonalcohol and alcohol cues (P3); and 2) a doors task (gambling task in which participants make a choice between two doors with either positive or negative feedback about reward outcome) for both immediate and delayed rewards (RewP). During the award period, the applicant will undergo advanced training in alcohol misuse, electrophysiology, behavioral economics, neuroeconomics, and longitudinal data analysis, preparing the applicant for a career as an expert in behavioral economics and electrophysiology. This study provides a translational understanding of reward processing, an important mechanism related to alcohol-related pathology (NIAAA strategic plan Goal 1), and evaluates multiple indices of reward processing as predictors of alcohol misuse. This investigation may establish an electrophysiological biomarker of diminished alcohol-free reward response with the potential to improve the diagnosis and the prediction of the trajectory of alcohol use disorder (NIAAA strategic plan Goal 2). Results from this project will inform future efforts in behavioral economic theory and intervention development.

7. 项目总结/文摘

项目成果

Posttraumatic stress disorder, drinking to cope, and harmful alcohol use: A multivariate meta-analysis of the self-medication hypothesis.

• DOI: 10.1037/abn0000764
• 发表时间: 2022-07
• 期刊: JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
• 作者: Luciano, Matthew T;Acuff, Samuel F;Olin, Cecilia C;Lewin, Rivian K;Strickland, Justin C;McDevitt-Murphy, Meghan E;Murphy, James G
• 通讯作者: Murphy, James G

Behavioral economics and the aggregate versus proximal impact of sociality on heavy drinking.

• DOI: 10.1016/j.drugalcdep.2021.108523
• 发表时间: 2021-03-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Acuff SF;Stoops WW;Strickland JC
• 通讯作者: Strickland JC

Reinforcer pathology of internet-related behaviors among college students: Data from six countries.

• DOI: 10.1037/pha0000459
• 发表时间: 2022-10
• 期刊: Experimental and clinical psychopharmacology
• 影响因子: 2.3
• 作者: Acuff SF;Pilatti A;Collins M;Hides L;Thingujam NS;Chai WJ;Yap WM;Shuai R;Hogarth L;Bravo AJ;Murphy JG
• 通讯作者: Murphy JG