Maternal inflammation during pregnancy and neurodevelopmental disorders
怀孕期间母体炎症和神经发育障碍
基本信息
- 批准号:10172956
- 负责人:
- 金额:$ 62.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-15 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnimal ModelArchivesBiologicalBiological AssayBiological MarkersBirthBlood specimenC-reactive proteinCaliforniaCaringCerebral PalsyCharacteristicsChildClinicalClinical DataCollectionCommunicable DiseasesDataDevelopmentDevelopmental Delay DisordersDiagnosisDiseaseDisease MarkerEarly InterventionEarly identificationElectronic Health RecordEnvironmentEnvironmental ExposureEnvironmental Risk FactorFirst Pregnancy TrimesterFundingFutureGenesGeneticGestational DiabetesHealthHeritabilityHumanImmuneImmunoglobulinsImmunologic MarkersIndividualInflammationInflammatoryLanguageLeadLearningLightLinkLipidsMaternal HealthMeasuresMediatingMedicalMetabolicMetabolic DiseasesMorbidity - disease rateMothersNeuraxisNeurodevelopmental DisorderNon-Insulin-Dependent Diabetes MellitusNonverbal CommunicationOutcomePatternPhenotypePregnancyPregnant WomenPrevalencePrevention strategyPrimary PreventionQuality of lifeResearchRiskRisk FactorsRoleSecond Pregnancy TrimesterSystemTimeTranslatingUnited Statesadipokinesautism spectrum disorderbiomarker identificationchemokinecohortcytokinedisorder riskepidemiology studyfetalgenetic analysisgenome-wideglucose toleranceimprovedlife time costmaternal conditionmetabolic profilemodifiable riskmotor impairmentneurodevelopmentneuropsychiatryoffspringpostnatal periodpregnancy disorderprenatalprenatal testingprepregnancy obesitypreventprogramsprospectivepublic health relevancesocietal costsstemstudy population
项目摘要
ABSTRACT
Neurodevelopmental disorders (NDD) are a group of disorders in which the development of the central nervous
system is disturbed. Approximately one in six children in the United States is affected by NDD, and the lifetime
cost of supporting one individual with NDD exceeds $2 million. Commonly known NDD include autism
spectrum disorders (ASD), cerebral palsy (CP), and developmental delays (DD). The causes of NDD are
largely unknown, and few modifiable risk factors have been identified. A growing body of evidence supports a
critical role for both genetic and environmental factors, particularly during gestation and the early postnatal
period. Common immune-mediated and metabolic conditions as well as levels of immune and metabolic
biomarkers have been shown to be associated with NDD risk. Furthermore, the immune and metabolic
systems influence each other, and are in turn genetically-influenced. Our central hypothesis is that maternal
inflammation during pregnancy stemming from immune or metabolic dysregulation will adversely impact child
neurodevelopment. Previous studies of gestational markers of NDD risk primarily focused on one specific
NDD, measured immune biomarkers at only one point in pregnancy, and didn't take into account maternal
genetics or environmental exposures. We seek to overcome the limitations of previous studies and extend
earlier findings linking maternal immune and metabolic function during pregnancy with increased risk of NDD
by leveraging the comprehensive data previously collected for the Kaiser Permanente Research Program on
Genes Environment and Health (RPGEH) Pregnancy Cohort, which includes ~15,000 pregnant women with
archived first and second trimester blood samples, comprehensive information on demographic characteristics,
maternal clinical status before and during pregnancy, and child outcomes from electronic health records. We
seek funds to perform immune and metabolic assays on first and second trimester blood samples from
mothers who gave birth to children diagnosed with ASD (N=150), CP (N=60), DD (N=1500), or who have no
NDD (N=1000) and generate genome-wide maternal SNP data to support analyses addressing the following
aims: 1) Characterize the maternal immune and metabolic profiles over pregnancy and evaluate whether there
are specific longitudinal patterns that are associated with neurodevelopmental outcomes in the offspring, and
2) Identify maternal factors (demographic and clinical characteristics, genetics) that are associated with altered
maternal immune or metabolic function during pregnancy and risk of different neurodevelopmental outcomes.
Our study has the potential to identify immune and metabolic profiles during pregnancy that indicate risk for
specific NDD. This would support the development of prenatal screening for NDD, leading to earlier
intervention and the potential for preventing future morbidity and improving quality of life. Furthermore, the
identification of prenatal biomarkers will illuminate the biologic mechanisms underlying aberrant
neurodevelopment and provide an opportunity for developing preventive strategies.
摘要
神经发育障碍(NDD)是一组中枢神经系统发育障碍,
系统受到干扰。在美国,大约六分之一的儿童受到NDD的影响,
支持一个NDD患者的费用超过200万美元。常见的NDD包括自闭症
谱系障碍(ASD)、脑瘫(CP)和发育迟缓(DD)。NDD的原因是
大多数情况下是未知的,很少有可改变的风险因素被确定。越来越多的证据表明,
遗传和环境因素的关键作用,特别是在妊娠期和产后早期
期常见的免疫介导和代谢疾病以及免疫和代谢水平
生物标志物已显示与NDD风险相关。此外,免疫和代谢
系统相互影响,反过来又受到基因的影响。我们的核心假设是,
怀孕期间因免疫或代谢失调而引起的炎症将对孩子产生不利影响
神经发育以前的NDD风险的妊娠标志物的研究主要集中在一个特定的
NDD只在怀孕期间的一个时间点测量免疫生物标志物,并且没有考虑母亲的
遗传学或环境暴露。我们试图克服以往研究的局限性,
早期发现将妊娠期间母体免疫和代谢功能与NDD风险增加联系起来
通过利用以前为凯撒永久研究计划收集的全面数据,
基因环境与健康(RPGEH)妊娠队列,其中包括约15,000名孕妇,
存档的第一和第二个三个月的血液样本,人口统计学特征的综合信息,
母亲在怀孕前和怀孕期间的临床状况,以及电子健康记录的儿童结局。我们
寻求资金,对怀孕早期和中期的血液样本进行免疫和代谢检测,
患有ASD(N=150)、CP(N=60)、DD(N=1500)或无ASD的母亲
NDD(N=1000),并生成全基因组母体SNP数据,以支持解决以下问题的分析
目的:1)描述妊娠期母体免疫和代谢状况,并评估是否存在
是与后代神经发育结果相关的特定纵向模式,
2)确定与改变的母亲因素(人口统计学和临床特征,遗传学)
母亲在怀孕期间的免疫或代谢功能和不同的神经发育结果的风险。
我们的研究有可能确定怀孕期间的免疫和代谢特征,这些特征表明
具体NDD。这将支持NDD产前筛查的发展,从而更早地
因此,我们认为,这是一项非常重要的干预措施,也是预防未来发病和提高生活质量的潜力所在。而且
产前生物标志物的鉴定将阐明异常妊娠的生物学机制。
神经发育,并为制定预防策略提供机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
LISA A CROEN其他文献
LISA A CROEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('LISA A CROEN', 18)}}的其他基金
Maternal Inflammation during Pregnancy and Neurodevelopmental Disorders
怀孕期间的母体炎症和神经发育障碍
- 批准号:
10188232 - 财政年份:2020
- 资助金额:
$ 62.21万 - 项目类别:
Maternal inflammation during pregnancy and neurodevelopmental disorders
怀孕期间母体炎症和神经发育障碍
- 批准号:
10393088 - 财政年份:2018
- 资助金额:
$ 62.21万 - 项目类别:
Maternal inflammation during pregnancy and neurodevelopmental disorders
怀孕期间母体炎症和神经发育障碍
- 批准号:
10407590 - 财政年份:2018
- 资助金额:
$ 62.21万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10469410 - 财政年份:2016
- 资助金额:
$ 62.21万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10239160 - 财政年份:2016
- 资助金额:
$ 62.21万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10745230 - 财政年份:2016
- 资助金额:
$ 62.21万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10205624 - 财政年份:2016
- 资助金额:
$ 62.21万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
9726480 - 财政年份:2016
- 资助金额:
$ 62.21万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10002319 - 财政年份:2016
- 资助金额:
$ 62.21万 - 项目类别:
Prenatal SSRI Exposure, Maternal and Child Genotype, and Autism Spectrum Disorders
产前 SSRI 暴露、母婴基因型和自闭症谱系障碍
- 批准号:
9246557 - 财政年份:2016
- 资助金额:
$ 62.21万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 62.21万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 62.21万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 62.21万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 62.21万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 62.21万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 62.21万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 62.21万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 62.21万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 62.21万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 62.21万 - 项目类别:
Grant-in-Aid for Early-Career Scientists