Maternal inflammation during pregnancy and neurodevelopmental disorders
怀孕期间母体炎症和神经发育障碍
基本信息
- 批准号:10407590
- 负责人:
- 金额:$ 60.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-15 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnimal ModelArchivesBiologicalBiological AssayBiological MarkersBirthBlood specimenC-reactive proteinCaliforniaCaringCerebral PalsyCharacteristicsChildClinicalClinical DataCollectionCommunicable DiseasesDataDevelopmentDevelopmental Delay DisordersDiagnosisDiseaseDisease MarkerEarly InterventionEarly identificationElectronic Health RecordEnvironmentEnvironmental ExposureEnvironmental Risk FactorFirst Pregnancy TrimesterFundingFutureGenesGeneticGestational DiabetesHealthHeritabilityHumanImmuneImmunoglobulinsImmunologic MarkersIndividualInflammationInflammatoryLanguageLeadLearningLightLinkLipidsMaternal HealthMeasuresMediatingMedicalMetabolicMetabolic DiseasesMorbidity - disease rateMothersNeuraxisNeurodevelopmental DisorderNon-Insulin-Dependent Diabetes MellitusNonverbal CommunicationOutcomePatternPhenotypePregnancyPregnant WomenPrevalencePrevention strategyPrimary PreventionQuality of lifeResearchRiskRisk FactorsRoleSecond Pregnancy TrimesterSystemTimeTranslatingUnited Statesadipokinesautism spectrum disorderbiomarker identificationchemokinecohortcytokinedisorder riskepidemiology studyfetalgenetic analysisgenome-wideglucose toleranceimprovedlife time costmaternal conditionmetabolic profilemodifiable riskmotor impairmentneurodevelopmentneuropsychiatryoffspringpostnatal periodpregnancy disorderprenatalprenatal testingprepregnancy obesitypreventprogramsprospectivepublic health relevancesocietal costsstemstudy population
项目摘要
ABSTRACT
Neurodevelopmental disorders (NDD) are a group of disorders in which the development of the central nervous
system is disturbed. Approximately one in six children in the United States is affected by NDD, and the lifetime
cost of supporting one individual with NDD exceeds $2 million. Commonly known NDD include autism
spectrum disorders (ASD), cerebral palsy (CP), and developmental delays (DD). The causes of NDD are
largely unknown, and few modifiable risk factors have been identified. A growing body of evidence supports a
critical role for both genetic and environmental factors, particularly during gestation and the early postnatal
period. Common immune-mediated and metabolic conditions as well as levels of immune and metabolic
biomarkers have been shown to be associated with NDD risk. Furthermore, the immune and metabolic
systems influence each other, and are in turn genetically-influenced. Our central hypothesis is that maternal
inflammation during pregnancy stemming from immune or metabolic dysregulation will adversely impact child
neurodevelopment. Previous studies of gestational markers of NDD risk primarily focused on one specific
NDD, measured immune biomarkers at only one point in pregnancy, and didn't take into account maternal
genetics or environmental exposures. We seek to overcome the limitations of previous studies and extend
earlier findings linking maternal immune and metabolic function during pregnancy with increased risk of NDD
by leveraging the comprehensive data previously collected for the Kaiser Permanente Research Program on
Genes Environment and Health (RPGEH) Pregnancy Cohort, which includes ~15,000 pregnant women with
archived first and second trimester blood samples, comprehensive information on demographic characteristics,
maternal clinical status before and during pregnancy, and child outcomes from electronic health records. We
seek funds to perform immune and metabolic assays on first and second trimester blood samples from
mothers who gave birth to children diagnosed with ASD (N=150), CP (N=60), DD (N=1500), or who have no
NDD (N=1000) and generate genome-wide maternal SNP data to support analyses addressing the following
aims: 1) Characterize the maternal immune and metabolic profiles over pregnancy and evaluate whether there
are specific longitudinal patterns that are associated with neurodevelopmental outcomes in the offspring, and
2) Identify maternal factors (demographic and clinical characteristics, genetics) that are associated with altered
maternal immune or metabolic function during pregnancy and risk of different neurodevelopmental outcomes.
Our study has the potential to identify immune and metabolic profiles during pregnancy that indicate risk for
specific NDD. This would support the development of prenatal screening for NDD, leading to earlier
intervention and the potential for preventing future morbidity and improving quality of life. Furthermore, the
identification of prenatal biomarkers will illuminate the biologic mechanisms underlying aberrant
neurodevelopment and provide an opportunity for developing preventive strategies.
摘要
项目成果
期刊论文数量(0)
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{{ truncateString('LISA A CROEN', 18)}}的其他基金
Maternal Inflammation during Pregnancy and Neurodevelopmental Disorders
怀孕期间的母体炎症和神经发育障碍
- 批准号:
10188232 - 财政年份:2020
- 资助金额:
$ 60.9万 - 项目类别:
Maternal inflammation during pregnancy and neurodevelopmental disorders
怀孕期间母体炎症和神经发育障碍
- 批准号:
10393088 - 财政年份:2018
- 资助金额:
$ 60.9万 - 项目类别:
Maternal inflammation during pregnancy and neurodevelopmental disorders
怀孕期间母体炎症和神经发育障碍
- 批准号:
10172956 - 财政年份:2018
- 资助金额:
$ 60.9万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10469410 - 财政年份:2016
- 资助金额:
$ 60.9万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10745230 - 财政年份:2016
- 资助金额:
$ 60.9万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10239160 - 财政年份:2016
- 资助金额:
$ 60.9万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10205624 - 财政年份:2016
- 资助金额:
$ 60.9万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
9726480 - 财政年份:2016
- 资助金额:
$ 60.9万 - 项目类别:
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
生命早期接触内分泌干扰化学物质与儿童生长、肥胖和神经发育
- 批准号:
10002319 - 财政年份:2016
- 资助金额:
$ 60.9万 - 项目类别:
Prenatal SSRI Exposure, Maternal and Child Genotype, and Autism Spectrum Disorders
产前 SSRI 暴露、母婴基因型和自闭症谱系障碍
- 批准号:
9246557 - 财政年份:2016
- 资助金额:
$ 60.9万 - 项目类别:
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