Facilitating a Multi-Institutional Enterprise

精准医学生物模块多尺度系统生物技术资源中心(CBM2) 管理：促进多机构企业发展 摘要/摘要 用于精密医学的生物模块多尺度系统生物技术研究中心 正寻求通过这一竞争性续签申请继续其重要使命，已概述了 积极和高度创新的研究计划，将为分析产生新的技术平台 作为液体活组织检查倡议的一部分，从循环中获得标记。这些标记包括稀有的生物 细胞、游离DNA和细胞外小泡及其携带的分子货物(DNA、RNA和 蛋白质)。在其活跃的再现(2015-2020年)中，CBM2为分离这些液体创造了新的平台 可用于指导临床的活检标记物和基于扩增的分子分析 一些重要疾病状态的决策(例如，Precision Medicine)。此次竞争续订是独一无二的 是创新工具的发展，使液体活检的分子货物分析无需 将提供独特机会的扩增，例如分析DNA和 RNA。我们的平台技术是创新的，因为分离步骤将集成到分子分析中 形成完全自动化的混合规模(微米和纳米技术)和模块化流体系统的步骤。《流体学》 系统将填充由即将到期的P41以及创新的P41生产的任务特定模块 在这场竞争性的更新中从研发部门进化而来。所有模块均采用注塑塑料制造。 模压成型。这些模块也可以作为独立的单元使用，以便于传播。 CBM2设想的崇高目标将通过一个成就卓著的多学科团队实现 拥有互补技能的几个机构的研究人员。行政管理的核心是 中心将寻求协调中心研究人员之间的活动，以积极推动研究 及时推进计划，提供令人信服的产出，不仅提供独特的机会 对于该中心的协作和服务项目，而是整个生物医学界。该中心的 领导团队在管理大型研究机构方面拥有丰富的经验，这些机构 在研究社区内取得了成功，并为 各种对液体活组织检查和混合比例制作感兴趣的观众。领导班子将 协调中心与其协作项目的研究工作，以支持应用程序驱动 拟议技术的开发。该中心精通将其技术过渡到 商业部门促进传播，这将通过服务项目提高中心的知名度。这个 该中心采用的系统设计方法(模块化格式)将促进集成流体的生成 用于自动化复杂分析的系统。协作和服务项目也将从中心发展而来 通过参与性培训和传播方案，包括一个强大的网站和广泛的网络 由领导班子和积极的访问学者计划提供。

Title: Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine Administration: Facilitating a Multi-Institutional Enterprise Abstract/Summary The Biotechnology Research Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine, which is seeking to continue its important mission through this competitive renewal application, has outlined an aggressive and highly innovative research program that will generate new technology platforms for the analysis of markers secured from circulation as part of the Liquid Biopsy initiative. These markers include rare biological cells, cell free DNA, and extracellular vesicles as well as the molecular cargo they carry (DNAs, RNAs, and proteins). In its active rendition (2015-2020), CBM2 generated new platforms for the isolation of these liquid biopsy markers and amplification-based molecular assays of their cargo that can be used to guide clinical decisions for a number of important disease states (i.e., Precision Medicine). Unique to this competitive renewal is the evolution of innovative tools to enable the analysis of the liquid biopsy's molecular cargo without requiring amplification that will provide unique opportunities, such as the analysis of epigenetic modifications in DNAs and RNAs. Our platform technology is innovative in that the isolation steps will be integrated to the molecular analysis steps to form fully automated mixed-scale (micro- and nanotechnologies) and modular fluidic systems. The fluidic systems will be populated with task specific modules produced from the expiring P41 as well as innovative ones evolving from the TR&Ds in this competitive renewal. All modules are manufactured in plastics using injection compression molding. The modules can also be used as standalone units to facilitate dissemination. The lofty goals envisioned by CBM2 will be realized through an accomplished multidisciplinary team of researchers across several institutions that possess complementary skill sets. The Administrative Core of the Center will seek to coordinate activities between the Center's researchers to aggressively move the research program forward in a timely manner to provide compelling outputs that will not only provide unique opportunities for the Center's Collaborative and Service Projects, but the biomedical community as a whole. The Center's leadership team is seasoned with extensive experiences in managing large research organizations that have demonstrated success within the research community as well as generating compelling training programs for a variety of audiences with an interest in liquid biopsies and mixed-scale fabrication. The Leadership Team will coordinate the research efforts of the Center with its Collaborative Projects to allow for application driven development of the proposed technologies. The Center is well versed in transitioning its technologies into the commercial sector to facilitate dissemination that will increase Center visibility through Service Projects. The system design approach adopted by the Center (modular format) will facilitate the generation of integrated fluidic systems for automating complex assays. Collaborative and Service Projects will also evolve from the Center through the engaging Training and Dissemination Program including a robust website and extensive networks provided by the Leadership Team as well as an active Visiting Scholar's Program.