Training in Molecular Toxicology

这是加州大学洛杉矶分校"分子毒理学培训"培训补助金的更新， 2014.我们的高度跨学科的计划，独特地专注于毒性机制，聚集了来自11个国家的教师。 加州大学洛杉矶分校4所不同学校的部门背后的共同目标是指导博士前和 博士后研究生在调查的毒理剂的作用机制和 评估其对健康和环境的影响。我们的具体方案目标是：（1） 在机制毒理学方面促进新颖和科学前沿的跨学科研究;（2）提供 教学和动手研究经验，以创建从分子毒理学的全面培训 和大型分子数据集的病理和疾病;（3）使用实验室研究，以模拟阳性 为学员未来的职业生涯提供指导和教学技能;（4）培养学员的软技能，包括写作 出版物和赠款的技能，演讲技巧和网络技能;（5）创建一个 欢迎，参与，尊重的培训环境，在所有措施中都是多样化的，每个受训者都感到 他们在更大的社区中有发言权，是有价值的贡献者。我们要求四名博士预科生 和两个博士后职位。要求提供这一数目的受训人员职位的理由是， NIEHS和非NIEHS资助我们的教师（平均每人每年直接成本为498，701美元），我们的 成功招募优秀的博士前和博士后培训生，我们在URM培训生方面的成功努力 招聘，最近的学员在高影响力期刊（包括自然）上的出色出版记录 通信，PNAS，PLoS Genetics，Cell Reports，Environmental Health Perspectives，Cancer Research，J. Biol. 化学成分：神经科学，遗传学，植物细胞和免疫学），以及我们过去的成功转型 在学术界、政府或工业界担任重要职位。加州大学洛杉矶分校分子毒理学 该计划得到了加州大学洛杉矶分校的大力支持，加州大学洛杉矶分校为此投入了大量资源，包括 招聘了一个新的教师，在分子毒理学领域的国家资助的终身职位， 疾病分子毒理学也是未来招聘的重点之一。教师有 七个主要研究领域：神经毒理学（特别是农药在病原学中的作用） 帕金森氏病），空气污染（二手烟，野火烟雾和 化石燃料及其燃烧产物）、毒理-表观遗传学（内分泌干扰物和其他 毒物），纳米毒理学，大数据/计算毒理学，基因-环境相互作用和易感性， 以及替代模式生物和预测毒理学。这些研究重点与以下方面高度相关： 加州和全国面临的环境挑战。延长培训补助金将进一步 刺激加州大学洛杉矶分校的分子毒理学研究和培训，应该鼓励更多的学生， 博士后从事毒理学研究，并将标志着毒理学在加州大学洛杉矶分校日益重要。

This is a renewal of the training grant “Training in Molecular Toxicology” at UCLA that was last renewed in 2014. Our highly interdisciplinary program, uniquely focused on mechanisms of toxicity, gathers faculty from 11 departments in 4 different schools at UCLA behind the common goal of mentoring pre-doctoral and postdoctoral trainees in the investigation of the mechanisms of action of toxicological agents and the evaluation of their impacts on health and the environment. Our specific programmatic objectives are to (1) Foster novel and scientifically cutting-edge interdisciplinary research in mechanistic toxicology; (2) Provide didactic and hands-on research experience to create a comprehensive training in toxicology from molecules and large molecular datasets to pathology and disease; (3) Use laboratory research to model positive mentoring and teaching skills for trainees' future careers; (4) Develop our trainees' soft skills, including writing skills for publications and grants, speaking skills for presentations, and networking skills; (5) Create a welcoming, engaging, respectful training environment that is diverse in all measures, where each trainee feels that they have a voice and are a valued contributor within a larger community. We request four predoctoral slots and two postdoctoral slots. This number of trainee positions requested is justified by the substantial NIEHS and non-NIEHS funding of our faculty (averaging $498,701 total annual direct costs per person), our success in recruiting excellent predoctoral and postdoctoral trainees, our successful endeavors in URM trainee recruitment, the excellent publication record of the recent trainees in high impact journals (including Nature Comm., PNAS, PLoS Genetics, Cell Reports, Environmental Health Perspectives, Cancer Research, J. Biol. Chem., J. Neuroscience, Genetics, Plant Cell, and J. Immunology), and the successful transition of our past trainees into important positions in academia, government or industry. The UCLA Molecular Toxicology program is well supported by UCLA, which has committed considerable resources to it, including the recruitment of a new faculty for a state-funded tenure-track position in the area of the molecular toxicology of disease. Molecular toxicology is also one of the hiring priorities for another future recruitment. The faculty have seven major foci of research interests: neurotoxicology (particularly the role of pesticides in the etiology of Parkinson's disease), air pollution (the toxic effects of secondhand cigarette smoke, wild-fire smoke, and of fossil fuels and their combustion products), toxico-epigenetics (effects of endocrine disruptors and other toxicants), nanotoxicology, big data/computational toxicology, gene-environment interactions and susceptibility, and alternative model organisms and predictive toxicology. These research foci are highly relevant to environmental challenges confronting California and the nation. Renewal of the training grant will further stimulate molecular toxicological research and training at UCLA, should encourage more students and postdocs to pursue research in toxicology, and will signal the increasing importance of toxicology at UCLA.