Training in Molecular Toxicology

分子毒理学培训

• 批准号: 9100716
• 负责人: OLIVER nmn HANKINSON
• 金额: $ 21.2万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9100716
• 关键词: Molecular Toxicology; Training

DESCRIPTION (provided by applicant) This is a renewal of the training grant "Training in Molecular Toxicology" at UCLA that was first funded in 2008. The training grant has catalyzed the expansion and consolidation of molecular toxicological research and training at UCLA and has stimulated interactions and collaborations among the participating faculty and the pre- and postdoctoral trainees. During the current funding period, the number of training grant faculty members increased from nine to fourteen. The faculty has primary appointments in nine different departments at UCLA. Four of the new appointees are Assistant Professors, and represent potential future leaders of the program. Seven of the faculty members have M.D. degrees. These faculty provides a potential avenue for the recruitment of physician-scientists to postdoctoral (and perhaps also pre-doctoral) positions in the training grant. The training grant requests support for five years and for four pre-doctoral students in the Molecular Toxicology Interdepartment Doctoral Program (IDP) at UCLA, and two postdoctoral trainees in the laboratories of the training grant faculty. Pre-doctoral trainees wil usually be appointed for three years, and postdoctoral trainees will be appointed for up to two years. In general, only pre-doctoral trainees who have completed their first year (during which most do rotations) will be awarded positions on the training grant. This number of trainee positions requested is justified by the increase in the number of our faculty, their substantial NIEHS and non-NIEHS funding, the investigators' previous success in recruiting excellent pre-doctoral and postdoctoral trainees, and the excellent publication record of the trainees. The faculty has a common interest in the mechanisms whereby environmental toxins cause disease. There are four major foci of research interest: i) The role of pesticides in the etiology of Parkinson's disease, ii) genetic damage (including carcinogenesis) caused by environmental agents, (iii) the toxic effects of secondhand cigarette smoke and of fossil fuels and their combustion products, and iv) nanotoxicology. Other areas of research pursued by individual faculty include metal toxicity and the analysis of transcription networks in toxicity. The UCLA Vice Chancellor for Research very recently announced a "Grand Challenge" initiative. One of the six Challenges focuses on preventing diseases associated with energy, pesticides and environmental technologies. The training grant faculty and trainees are poised to make major contributions to this endeavor. The UCLA Academic Senate undertook an eight year review of the Molecular Toxicology IDP in 2010, and an External Advisory Committee reviewed the training grant in 2011. The Committees were clearly impressed with the IDP and the attainments of the training grant. UCLA has committed considerable resources to the Molecular Toxicology Program, and institutional support is very strong. Over the next five years the NIEHS training grant will further enhance and stimulate molecular toxicological research and training at UCLA, should encourage more students and postdoctoral fellows to pursue research in toxicology, and will signal the increasing importance of toxicology as a discipline at UCLA.

描述（由申请人提供） 这是加州大学洛杉矶分校“分子毒理学培训”培训资助的延续，该培训资助于 2008 年首次资助。该培训资助促进了加州大学洛杉矶分校分子毒理学研究和培训的扩展和巩固，并刺激了参与教师以及博士前和博士后学员之间的互动和合作。在当前资助期间，培训补助金教员人数从九人增加到十四人。该教师在加州大学洛杉矶分校的九个不同系担任主要职务。 新任命的四名人员是助理教授，代表了该项目未来潜在的领导者。七名教师拥有医学博士学位。这些教师为在培训补助金中招募医师科学家担任博士后（也许还有博士前）职位提供了潜在的途径。培训补助金要求支持五年和四名博士前 加州大学洛杉矶分校分子毒理学跨部门博士项目 (IDP) 的学生，以及培训资助教师实验室的两名博士后实习生。 博士前实习生的任期通常为三年，博士后实习生的任期最长为两年。 一般来说，只有完成第一年（大多数人在此期间进行轮换）的博士前培训生才会获得培训补助金。所要求的实习生职位数量是合理的，因为我们的教职人员数量增加，其大量的 NIEHS 和非 NIEHS 资助，研究人员之前成功招募了优秀的博士前和博士后实习生，以及实习生的出色发表记录。教师们对环境毒素引起疾病的机制有着共同的兴趣。研究兴趣主要集中在四个方面：i) 农药在帕金森病病因学中的作用，ii) 环境因素引起的遗传损伤（包括致癌），(iii) 二手烟烟雾和化石燃料及其燃烧产物的毒性作用，以及 iv) 纳米毒理学。个别教师从事的其他研究领域包括金属毒性和毒性转录网络分析。加州大学洛杉矶分校负责研究的副校长最近宣布了一项“大挑战”计划。六大挑战之一的重点是预防与能源、农药和环境技术相关的疾病。培训补助金教师和学员准备为这一努力做出重大贡献。加州大学洛杉矶分校学术参议院于 2010 年对分子毒理学 IDP 进行了为期八年的审查，外部咨询委员会于 2011 年审查了培训补助金。委员会对 IDP 和培训补助金的成就印象深刻。加州大学洛杉矶分校为分子毒理学项目投入了大量资源，机构支持也非常强大。未来五年，NIEHS 培训补助金将进一步加强和刺激加州大学洛杉矶分校的分子毒理学研究和培训，鼓励更多的学生和博士后研究员从事毒理学研究，并将标志着毒理学作为加州大学洛杉矶分校一门学科的重要性与日俱增。