Training in Molecular Toxicology

分子毒理学培训

• 批准号: 8693345
• 负责人: OLIVER nmn HANKINSON
• 金额: $ 15.59万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8693345
• 关键词: Molecular Toxicology; Training

DESCRIPTION (provided by applicant) This training grant will support pre-doctoral and postdoctoral students in the Molecular Toxicology Interdepartmental Program (IDP) at the University of California, Los Angeles (UCLA). Prior to the establishment of the IDP in 2000, toxicological research and training was scattered through many departments at UCLA, and lacked cohesion and coordination. Establishment of the IDP focused training in one program and stimulated interactions and collaborations among the participating faculty and their students and postdoctoral fellows. The training grant will help further consolidate, improve and expand the Molecular Toxicology Program, and signal the "arrival" of toxicology as an important player in the biomedical sciences at UCLA. The nine faculty of the training grant have their primary appointments in seven different departments in three different schools. Nevertheless their laboratories/offices are in close proximity to one another. The faculty members have substantial NIEHS funding. Most importantly, they have a common interest in the mechanisms whereby toxicants induce disease. Several of the faculty members investigate the role of air pollution particulates in the exacerbation of asthma. Others investigate the carcinogenic/mutagenic effects of these and other environmental pollutants. A new area for the program is the role of pesticides in the etiology of Parkinson's disease. Capitalizing on their experience with ambient air particles, some of the faculty have begun research on the emerging field of the toxicity of manufactured nanoparticles (nanotoxicology). One pre- and one postdoctoral position is requested in the first year. These numbers will progressively increase to four and two, respectively, in the fifth year. Pre-doctoral students will be supported for up to three years after they have completed their first year of course work. Postdoctoral fellows will receive two years of support. Five of the nine mentoring faculty are physician-scientists. These faculty members will provide an avenue for the recruitment of physicians to postdoctoral positions in the training grant. The grant is highly relevant to public health. A better understanding of the processes whereby air pollution, pesticides and other environmental pollutants cause diseases, including asthma, cancer, and/or Parkinson's disease, will lead to improved risk assessment as well as methodologies for reducing or eliminating the deleterious effects of these environmental agents. BACKGROUND This is a resubmission of an application for a training grant in Molecular Toxicology at UCLA. This revised application has undergone substantial revision to address concerns of the previous review. Training grant preceptors without R01 type funding have been omitted and the number of preceptors has decreased from fifteen to nine. Course requirements have been changed to reflect the addition of more toxicology courses. Previous incomplete sections/tables are now generally complete. Dr. Hankinson, the Program Director, presented that among the 9 faculty members included in this current training grant, 7 now have substantial NIEHS funding. In response to the concern that none of the mentors is affiliated with environmental health sciences, Dr. Hankinson points out that one of the new members of the faculty (Dr. Froines) is a Professor in the Department of Environmental Health Sciences, while two other members of the faculty (Drs. Ritz and Schiestl) have secondary appointments in that Department. He also points out that it should be noted that the Molecular Toxicology Program is an interdepartmental program, and believes that the resulting broad perspective represents one of the strengths of the program.

描述（由申请人提供） 该培训补助金将支持加州大学洛杉矶分校（UCLA）分子毒理学跨部门项目（IDP）的博士前和博士后学生。 在2000年IDP成立之前，毒理学研究和培训分散在加州大学洛杉矶分校的许多部门，缺乏凝聚力和协调。IDP的建立集中在一个程序的培训，并刺激参与教师和他们的学生和博士后研究员之间的互动和合作。培训补助金将有助于进一步巩固，改善和扩大分子毒理学计划，并标志着毒理学作为生物医学科学的重要参与者在加州大学洛杉矶分校的“到来”。培训补助金的九个教员主要在三所不同学校的七个不同部门任职。然而，他们的实验室/办公室彼此非常接近。教师有大量的NIEHS资金。最重要的是，他们对有毒物质诱发疾病的机制有着共同的兴趣。一些教员调查了空气污染颗粒物在哮喘恶化中的作用。 其他人则研究这些和其他环境污染物的致癌/致突变作用。 该计划的一个新领域是杀虫剂在帕金森病病因学中的作用。 利用他们在环境空气颗粒方面的经验，一些教师已经开始对制造纳米颗粒的毒性（纳米毒理学）的新兴领域进行研究。 一个前和一个博士后职位要求在第一年。到第五年，这些数字将分别逐步增加到四个和两个。博士预科生将在完成第一年的课程后获得长达三年的支持。博士后研究员将获得两年的支持。九个指导教师中有五个是物理科学家。这些教员将为招聘医生到培训补助金中的博士后职位提供途径。该补助金与公共卫生密切相关。更好地了解空气污染、农药和其他环境污染物导致疾病（包括哮喘、癌症和/或帕金森病）的过程，将有助于改进风险评估以及减少或消除这些环境因素有害影响的方法。 背景 这是一份重新提交的加州大学洛杉矶分校分子毒理学培训资助申请。 这份修订后的申请已经过实质性修改，以解决上次审查中的问题。 没有R 01类型资金的培训补助导师被省略，导师人数从15人减少到9人。 课程要求已经改变，以反映更多的毒理学课程的增加。 以前不完整的章节/表格现在基本上完整了。 项目主任汉金森博士介绍说，在目前的培训补助金中包括的9名教员中，有7名现在有大量的NIEHS资金。 在回应的关注，没有导师是隶属于环境健康科学，博士汉金森指出，教师的新成员（博士Froines）是在环境健康科学系的教授，而教师的其他两名成员（博士里茨和Schiestl）在该部门的第二次任命。他还指出，应该注意的是，分子毒理学计划是一个跨部门的计划，并认为由此产生的广泛的观点代表了该计划的优势之一。