Training in Molecular Toxicology

分子毒理学培训

• 批准号: 9307826
• 负责人: OLIVER nmn HANKINSON
• 金额: $ 27.85万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9307826
• 关键词: Molecular Toxicology; Training

DESCRIPTION (provided by applicant) This is a renewal of the training grant "Training in Molecular Toxicology" at UCLA that was first funded in 2008. The training grant has catalyzed the expansion and consolidation of molecular toxicological research and training at UCLA and has stimulated interactions and collaborations among the participating faculty and the pre- and postdoctoral trainees. During the current funding period, the number of training grant faculty members increased from nine to fourteen. The faculty has primary appointments in nine different departments at UCLA. Four of the new appointees are Assistant Professors, and represent potential future leaders of the program. Seven of the faculty members have M.D. degrees. These faculty provides a potential avenue for the recruitment of physician-scientists to postdoctoral (and perhaps also pre-doctoral) positions in the training grant. The training grant requests support for five years and for four pre-doctoral students in the Molecular Toxicology Interdepartment Doctoral Program (IDP) at UCLA, and two postdoctoral trainees in the laboratories of the training grant faculty. Pre-doctoral trainees wil usually be appointed for three years, and postdoctoral trainees will be appointed for up to two years. In general, only pre-doctoral trainees who have completed their first year (during which most do rotations) will be awarded positions on the training grant. This number of trainee positions requested is justified by the increase in the number of our faculty, their substantial NIEHS and non-NIEHS funding, the investigators' previous success in recruiting excellent pre-doctoral and postdoctoral trainees, and the excellent publication record of the trainees. The faculty has a common interest in the mechanisms whereby environmental toxins cause disease. There are four major foci of research interest: i) The role of pesticides in the etiology of Parkinson's disease, ii) genetic damage (including carcinogenesis) caused by environmental agents, (iii) the toxic effects of secondhand cigarette smoke and of fossil fuels and their combustion products, and iv) nanotoxicology. Other areas of research pursued by individual faculty include metal toxicity and the analysis of transcription networks in toxicity. The UCLA Vice Chancellor for Research very recently announced a "Grand Challenge" initiative. One of the six Challenges focuses on preventing diseases associated with energy, pesticides and environmental technologies. The training grant faculty and trainees are poised to make major contributions to this endeavor. The UCLA Academic Senate undertook an eight year review of the Molecular Toxicology IDP in 2010, and an External Advisory Committee reviewed the training grant in 2011. The Committees were clearly impressed with the IDP and the attainments of the training grant. UCLA has committed considerable resources to the Molecular Toxicology Program, and institutional support is very strong. Over the next five years the NIEHS training grant will further enhance and stimulate molecular toxicological research and training at UCLA, should encourage more students and postdoctoral fellows to pursue research in toxicology, and will signal the increasing importance of toxicology as a discipline at UCLA.

描述（由申请人提供） 这是对加州大学洛杉矶分校2008年首次资助的“分子毒理学培训”培训补助金的更新。培训补助金促进了加州大学洛杉矶分校分子毒理学研究和培训的扩展和巩固，并刺激了参与教师和博士前和博士后学员之间的互动和合作。在目前的资助期间，培训补助金的教员人数从9人增加到14人。该学院在加州大学洛杉矶分校的九个不同部门有主要任命。 新任命的四名助理教授，并代表该计划的潜在未来领导者。其中7名教师拥有医学博士学位。度这些学院提供了一个潜在的途径，招聘医生科学家的博士后（也许也是博士前）的位置在培训补助金。培训补助金要求支持五年和四个博士前 在分子毒理学跨部门博士课程（IDP）在加州大学洛杉矶分校的学生，和两名博士后学员在实验室的培训补助金教师。 博士前培训生的聘用期通常为三年，博士后培训生的聘用期最长为两年。 一般来说，只有完成第一年（大多数人在此期间进行轮换）的博士前学员才能获得培训补助金。要求的实习生职位的数量是合理的增加我们的教师，他们的大量NIEHS和非NIEHS资金，研究人员以前成功招募优秀的博士前和博士后学员，以及学员的优秀出版记录。该学院对环境毒素引起疾病的机制有着共同的兴趣。有四个主要的研究热点：一）农药在帕金森氏病病因学中的作用，二）环境因素引起的遗传损伤（包括致癌作用），（三）二手香烟烟雾和化石燃料及其燃烧产物的毒性作用，以及iv）纳米毒理学。个别教师追求的其他研究领域包括金属毒性和毒性转录网络的分析。加州大学洛杉矶分校负责研究的副校长最近宣布了一项“大挑战”计划。六项挑战之一的重点是预防与能源、农药和环境技术有关的疾病。培训补助金的教师和学员准备为这一奋进作出重大贡献。加州大学洛杉矶分校学术委员会于2010年对分子毒理学IDP进行了为期八年的审查，外部咨询委员会于2011年审查了培训补助金。委员会显然对国内流离失所者和培训补助金的落实情况印象深刻。加州大学洛杉矶分校已承诺相当多的资源，分子毒理学计划，和机构的支持是非常强大的。在接下来的五年里，NIEHS培训补助金将进一步加强和刺激加州大学洛杉矶分校的分子毒理学研究和培训，鼓励更多的学生和博士后研究员从事毒理学研究，并将标志着毒理学作为加州大学洛杉矶分校一门学科的重要性日益增加。