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Pennsylvania Surveillance for Antimicrobial Resistant-enteric Bacteria in Retail Food

宾夕法尼亚州零售食品中抗菌药物耐药性肠道细菌的监测

基本信息

批准号：
10175870
负责人：
NKUCHIA MUGAMBI M'IKANATHA
金额：
$ 17.5万
依托单位：
PENNSYLVANIA STATE DEPT OF HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10175870
关键词：
Pennsylvania Surveillance Antimicrobial Resistant enteric

项目摘要

Pennsylvania Surveillance for Antimicrobial Resistant-enteric Bacteria in Retail Food Abstract Antimicrobial resistance in human pathogens from contaminated food products including Salmonella from poultry meat and Acinetobacter from shrimps is of great concern. Pennsylvania is motivated to participate in National Antimicrobial Monitoring System (NARMS) retail food surveillance for two reasons. First, the program will enable us to contribute to the FDA's regulatory oversight for antibiotics, which directly benefits our residents. Second, it will enable us to strengthen integrated surveillance for enteric bacteria by using whole genome sequencing to compare bacteria from food samples with bacteria isolated from patients. This comparison facilitates outbreak investigations, trace-back of contaminated products, and prioritization of interventions such as facility inspections by regulators. Analyses of integrated genomics data from food and human sources will also enhance surveillance for antimicrobial resistance in enteric bacteria. This project will result in better coordination and exchange of data and isolates with the FDA and expand high resolution detection of and response to emerging drug-resistant pathogens. improved timelines of the surveillance system. Additionally, our efforts will improve data quality and completeness of records and will support the use of NARMS findings to improve One Health antimicrobial stewardship in food production and healthcare settings.

宾夕法尼亚州零售食品中抗菌药物耐药性肠道细菌的监测抽象的来自受污染食品的人类病原体的抗菌素耐药性包括家禽肉中的沙门氏菌和虾中的不动杆菌值得高度关注。宾夕法尼亚州有动力参与国家抗菌监测系统 (NARMS) 零售食品监视有两个原因。首先，该计划将使我们能够为 FDA 的对抗生素的监管监督，直接惠及我们的居民。其次，它将启用我们利用全基因组测序加强对肠道细菌的综合监测将食品样本中的细菌与从患者体内分离出的细菌进行比较。这个比较促进疫情调查、受污染产品的追溯以及优先处理监管机构进行设施检查等干预措施。综合基因组数据分析食品和人类来源也将加强对抗菌药物耐药性的监测肠道细菌。该项目将导致数据和隔离更好的协调和交换与 FDA 合作，扩大对新出现耐药性的高分辨率检测和应对病原体。改进了监控系统的时限。此外，我们的努力将提高数据质量和记录的完整性，并将支持 NARMS 调查结果的使用改善食品生产和医疗保健环境中的 One Health 抗菌管理。