Pennsylvania Retail Meat Program - Collaboration with FDA National Antimicrobial Resistance Monitoring Systems (NARMS)

宾夕法尼亚州零售肉类计划 - 与 FDA 国家抗菌素耐药性监测系统 (NARMS) 合作

• 批准号: 9768190
• 负责人: NKUCHIA MUGAMBI M'IKANATHA
• 金额: $ 11.47万
• 依托单位: PENNSYLVANIA STATE DEPT OF HEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768190
• 关键词: Pennsylvania; Retail; Meat; Program; Collaboration

Pennsylvania Integrated Surveillance for Antimicrobial Resistance Enteric Bacteria Abstract Antimicrobial resistance in foodborne pathogens of animal origin, including Salmonella and Campylobacter, is of great concern. Pennsylvania is motivated to continue to participate in National Antimicrobial Monitoring System (NARMS) retail meat surveillance for two reasons. First, the program enables us to contribute to the FDA’s regulatory oversight for antibiotics, which directly benefits our residents. Second, this program supports integrated surveillance for enteric bacteria by comparing clinical isolates involved in foodborne illnesses with those recovered from meat samples. This comparison facilitates outbreaks investigation, trace-back of contaminated products, and prioritization of slaughterhouse inspections by USDA Food Safety and Inspection Service. Key outcomes from our research strategy include better coordination and exchange of data and isolates with the FDA and improved timeliness of the surveillance system. Additionally, our efforts have and will continue to improve data quality and completeness of records. Further, use of NARMS surveillance findings have improved communication about judicious antibiotic use in the community and on the farm. Our research will include pre-approved pilot studies and all activities will be completed in state public health and veterinary laboratories and in research laboratories at Penn State College of Agricultural Sciences.

宾夕法尼亚州肠道细菌耐药性综合监测 摘要 动物源性食源性病原体（包括沙门氏菌和 弯曲杆菌，是一个很大的关注。宾夕法尼亚州有动力继续参与 国家抗菌素监测系统（NARMS）零售肉类监测有两个原因。 首先，该项目使我们能够为FDA对抗生素的监管做出贡献， 直接惠及居民第二，该方案支持综合监测， 通过比较涉及食源性疾病的临床分离株与 从肉类样本中提取的这种比较有助于疫情调查、 受污染的产品，以及美国农业部食品安全部门对屠宰场检查的优先顺序 和检查服务。我们研究战略的主要成果包括更好的协调 与FDA交换数据和分离株，提高监测的及时性 系统此外，我们的努力已经并将继续提高数据质量， 记录的完整性。此外，国家档案管理系统监测结果的使用情况有所改善， 在社区和农场中明智使用抗生素的沟通。我们的研究 将包括预先批准的试点研究，所有活动将在州公共卫生部门完成。 和兽医实验室以及宾夕法尼亚州立农业大学的研究实验室 以理工科为重

项目成果

Prevalence of Group I Salmonella Kentucky in domestic food animals from Pennsylvania and overlap with human clinical CRISPR sequence types.

宾夕法尼亚州家养食用动物中肯塔基州 I 类沙门氏菌的患病率以及与人类临床 CRISPR 序列类型的重叠。

• DOI: 10.1111/zph.12506
• 发表时间: 2018
• 期刊: Zoonoses and public health
• 影响因子: 2.4
• 作者: Rauch,HallieE;Vosik,Dorothy;Kariyawasam,Subhashinie;M'ikanatha,Nkuchia;Shariat,NikkiW
• 通讯作者: Shariat,NikkiW

Implementation of antimicrobial stewardship and infection prevention and control practices in long-term care facilities-Pennsylvania, 2017.

在长期护理机构中实施抗菌药物管理和感染预防和控制实践——宾夕法尼亚州，2017 年。

• DOI: 10.1017/ice.2019.80
• 发表时间: 2019
• 期刊: Infection control and hospital epidemiology
• 影响因子: 4.5
• 作者: M'ikanatha,NkuchiaM;Boktor,SamehW;Seid,Arlene;Kunselman,AllenR;Han,JenniferH
• 通讯作者: Han,JenniferH

Integrated Surveillance for Antimicrobial Resistance in Salmonella From Clinical and Retail Meat Sources Reveals Genetically Related Isolates Harboring Quinolone- and Ceftriaxone-Resistant Determinants.

• DOI: 10.1093/ofid/ofab213
• 发表时间: 2021-08
• 期刊: Open forum infectious diseases
• 影响因子: 4.2
• 作者: M'ikanatha NM;Yin X;Boktor SW;Dettinger LA;Tewari D
• 通讯作者: Tewari D

CRISPR Typing and Antibiotic Resistance Correlates with Polyphyletic Distribution in Human Isolates of Salmonella Kentucky.

CRISPR 分型和抗生素耐药性与肯塔基州沙门氏菌人类分离株的多系分布相关。

• DOI: 10.1089/fpd.2017.2298
• 发表时间: 2018
• 期刊: Foodborne pathogens and disease
• 影响因子: 2.8
• 作者: Vosik,Dorothy;Tewari,Deepanker;Dettinger,Lisa;M'ikanatha,NkuchiaM;Shariat,NikkiW
• 通讯作者: Shariat,NikkiW

Use of an annual art competition to promote Web site traffic and engage children in antimicrobial stewardship in Pennsylvania.

利用一年一度的艺术竞赛来促进网站流量并让宾夕法尼亚州的儿童参与抗菌管理工作。

• DOI: 10.1016/j.ajic.2017.06.035
• 发表时间: 2018
• 期刊: American journal of infection control
• 影响因子: 4.9
• 作者: M'ikanatha,NkuchiaM;Yealy,Courtney;Warrington,Anna-Marie;Reefer,Tabitha;Boktor,SamehW;Mueller,Natalie;Leonard,Mary;Hackman,NicoleM
• 通讯作者: Hackman,NicoleM