Pennsylvania Surveillance for Antimicrobial Resistant-enteric Bacteria in Retail Food

宾夕法尼亚州零售食品中耐药肠道细菌监测 摘要 受污染食品中人体病原体的抗药性 禽肉中的沙门氏菌和虾中的不动杆菌引起了人们的极大关注。宾夕法尼亚州 积极参与国家抗菌素监测系统(NARMS)零售食品 监视有两个原因。首先，该计划将使我们能够为FDA的 对抗生素的监管，这直接使我们的居民受益。第二，它将使 美国将通过全基因组测序加强对肠道细菌的综合监测 将食品样本中的细菌与从患者身上分离的细菌进行比较。这一比较 促进疫情调查、污染产品的追溯和优先处理 监管机构的设施检查等干预措施。综合基因组学数据分析 来自食物和人类来源的还将加强对#年抗菌素耐药性的监测 肠道细菌。该项目将导致更好地协调和交换数据和隔离 与FDA合作，扩大对新出现的耐药性的高分辨率检测和反应 病原体。改进了监视系统的时间表。此外，我们的努力将 提高数据质量和记录的完整性，并将支持使用NARMS调查结果 改善食品生产和保健环境中的One Health抗菌剂管理。

Pennsylvania Surveillance for Antimicrobial Resistant-enteric Bacteria in Retail Food Abstract Antimicrobial resistance in human pathogens from contaminated food products including Salmonella from poultry meat and Acinetobacter from shrimps is of great concern. Pennsylvania is motivated to participate in National Antimicrobial Monitoring System (NARMS) retail food surveillance for two reasons. First, the program will enable us to contribute to the FDA's regulatory oversight for antibiotics, which directly benefits our residents. Second, it will enable us to strengthen integrated surveillance for enteric bacteria by using whole genome sequencing to compare bacteria from food samples with bacteria isolated from patients. This comparison facilitates outbreak investigations, trace-back of contaminated products, and prioritization of interventions such as facility inspections by regulators. Analyses of integrated genomics data from food and human sources will also enhance surveillance for antimicrobial resistance in enteric bacteria. This project will result in better coordination and exchange of data and isolates with the FDA and expand high resolution detection of and response to emerging drug-resistant pathogens. improved timelines of the surveillance system. Additionally, our efforts will improve data quality and completeness of records and will support the use of NARMS findings to improve One Health antimicrobial stewardship in food production and healthcare settings.