Monitoring antimicrobial resistance among veterinary pathogens at Iowa State University Veterinary Diagnostic Laboratory: A Vet-LIRN AMR Surveillance Project

爱荷华州立大学兽医诊断实验室监测兽医病原体的抗菌药物耐药性：Vet-LIRN AMR 监测项目

• 批准号: 10599390
• 负责人: Orhan Sahin
• 金额: $ 2.08万
• 依托单位: IOWA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10599390
• 关键词: Monitoring; antimicrobial; resistance; among; veterinary

Project Summary/Abstract Monitoring antimicrobial resistance among veterinary pathogens at Iowa State University Veterinary Diagnostic Laboratory: A Vet-LIRN AMR Surveillance Project Antimicrobial resistance (AMR) is a major health threat affecting the well-being of humans, animals, and the environment worldwide. In the United States, Veterinary Laboratory Investigation and Response Network (Vet-LIRN) under the Food and Drug Administration, Center for Veterinary Medicine (FDA-CVM) performs surveillance of AMR in select veterinary bacterial pathogens (e.g., Salmonella, Escherichia coli, and Staphylococcus pseudintermedius) from animals by partnering with diagnostic laboratories throughout North America. Under the initiative, Iowa State University Veterinary Diagnostic Laboratory (ISU VDL) became a Vet- LIRN source laboratory and has participated the AMR surveillance program from the very beginning since 2017. The FDA Vet-LIRN program supports the network laboratories via cooperative agreements for research and surveillance for supplies, equipment, personnel and other related activities that are needed to expand laboratories’ capability and capacity. As part of this project, the ISU VDL collects bacterial isolates and sends them to a Genome Sequencing laboratory in another location. In this application, we propose to continue the collaborative partnership with Vet-LIRN to address the dynamic goals of the AMR Surveillance Program as partly described in FOA PAR-18-604 “Vet-LIRN Network Capacity-Building Projects”. Specifically, as a source laboratory, we will continue to isolate and identify bacterial pathogens of interests at ISU VDL, perform antimicrobial susceptibility testing, and share the isolates and antimicrobial susceptibility testing result with Vet-LIRN network on a quarterly basis following the Vet-LIRN protocol. We strongly believe that the ISU Veterinary Diagnostic Laboratory has substantially contributed to the capacity and effectiveness of the AMR surveillance project in veterinary pathogens over the past years, and would like to continue our existing partnership with the FDA Vet-LIRN in order to help the nationwide/global effort on combatting antimicrobial resistance in veterinary settings.

项目摘要/摘要 爱荷华州立大学兽医病原体中监测抗菌素的抗性 兽医诊断实验室：一项兽医AMR监视项目 抗菌耐药性（AMR）是影响人类福祉的主要健康威胁， 动物和全球环境。在美国，兽医实验室 食品和药物管理局的调查和响应网络（VET-LIRN）， 兽医中心（FDA-CVM）在精选兽医中对AMR进行监视 细菌病原体（例如沙门氏菌，大肠杆菌和葡萄球菌pseudintermedius） 通过与整个北美的诊断实验室合作从动物那里。在 爱荷华州立大学兽医诊断实验室（ISU VDL）倡议成为兽医 LIRN来源实验室，并参加了AMR监视计划 从2017年开始。FDAVET LIRN计划通过 有关供应，设备，人员和监视的合作协议 扩大实验室能力和能力所需的其他相关活动。作为 该项目，ISU VDL收集细菌分离株并将其发送到基因组测序 在另一个位置的实验室。在此应用程序中，我们建议继续协作 与LIRN的合作伙伴关系，以解决AMR监视计划的动态目标 在FOA PAR-18-604中，部分描述了“ Vet-Lirn网络能力建设项目”。 具体而言，作为来源实验室，我们将继续隔离并鉴定细菌病原体 ISU VDL的利益，进行抗菌敏感性测试，并共享分离株和 抗菌易感性测试结果是通过每季度使用兽医LIRN网络进行的 VET-LIRN协议。我们坚信，ISU兽医诊断实验室已经 大大促进了AMR监视项目的能力和有效性 过去几年兽医病原体，并希望继续我们现有的合作伙伴关系 借助FDA兽医LIRN，以帮助全国/全球努力打击 兽医环境中的抗菌素抗性。