Special Projects: Analytical Track 3: Method Development/Validation

特别项目：分析轨道 3：方法开发/验证

• 批准号: 10174023
• 负责人: SINISA URBAN
• 金额: $ 3.5万
• 依托单位: MARYLAND STATE DEPARTMENT OF HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10174023
• 关键词: Special; Projects; Analytical; Track; Method

SUMMARY: SPECIAL PROJECT TRACK 3 (METHOD DEVELOPMENT AND VALIDATION) The MDH Laboratories Administration places a high priority on developing and implementing cutting- edge technologies and capabilities. The core tenet of this large and multifaceted proposal is to contribute a comprehensive and integrated food protection laboratory hub to the Food Emergency Response Network (FERN) that is capable of analyzing many different foods across a diversity of threat priorities. Developing and validating new testing methods is thus central to achieving our goal of ensuring a safe food supply. Through this track the MDH Laboratories Administration proposes to conduct preliminary, short-term, or exploratory investigations, as needed by FERN, that focus on the feasibility of a new method and/or technology. The Laboratory will follow the Food & Drug Administration’s (FDA) guidelines for method validation as described in “Validation of Chemical Methods for the FDA FVM Program” to complete a one-year, single-laboratory validation study. The Division of Environmental Sciences has all of the instrumentation, including 5 ICP-MS and 3 LC-MS/MS mass spectrometers, multiple expert and experienced scientists, and established methodologies in place to perform these studies. Projects for each of the five years of this cooperative agreement will be chosen based on FERN needs, and/or proposed based on emerging local priorities and opportunities, in consultation with the FERN management team.

摘要：特别项目轨道 3（方法开发和验证） MDH 实验室管理局高度重视开发和实施切割 边缘技术和能力。这个大型且多方面提案的核心宗旨是贡献 食品紧急响应的综合性食品保护实验室中心 网络 (FERN) 能够分析各种威胁优先级的许多不同食物。 因此，开发和验证新的测试方法对于实现我们确保 安全食品供应。 MDH 实验室管理局建议通过这一途径开展 根据 FERN 的需要，进行初步、短期或探索性调查，重点关注以下项目的可行性： 新方法和/或技术。实验室将遵循美国食品药品监督管理局（FDA）的规定 方法验证指南，如“FDA FVM 化学方法验证”中所述 计划”来完成一项为期一年的单一实验室验证研究。环境司 Sciences 拥有所有仪器，包括 5 台 ICP-MS 和 3 台 LC-MS/MS 质谱仪， 多名专家和经验丰富的科学家，并建立了适当的方法来执行这些 研究。本合作协议五年内每年的项目将根据FERN进行选择 需求，和/或根据新出现的当地优先事项和机会提出的建议，并与 费恩管理团队。