CAHFS Method Development and Validation; Discipline D Track 3; 7/1/2020-6/30/2021

CAHFS 方法开发和验证；

• 批准号: 10173540
• 负责人: ROBERT HOWARD POPPENGA
• 金额: $ 2.82万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10173540
• 关键词: CAHFS; Method; Development; Validation; Discipline

Discipline D Track 3: Method Development and Method Validation Project Summary The FDA’s utilization of chemical analysis is critical to the agency’s ability to protect the U.S. food supply from unsafe chemical contamination. There are continuing needs for new analytical methods and techniques to handle the challenges involved with new food matrices and to make effective use of new and more efficient analytical technology. The purpose of this project is to provide funding for preliminary investigations into new analytical approaches, method extensions to new food matrices, and multi-laboratory research studies. The Toxicology Section of the California Animal Health and Food Safety Laboratory (CAHFS) has extensive experience in method development and extension projects and evaluation of new technologies. The nature of veterinary analytical toxicology is such that there are constant requirements for new methods to be developed. Some of these methods are required to handle single events of toxicosis in animals while others are designed to become routine methods for long-term use. The ability to execute such development projects is integral to the Section’s mission of assuring the health of agricultural animals and the safety of their feeds in California. The Section maintains a variety of different types of instrumentation allowing for flexibility in analyte detection and the ability to analyze a wide variety of matrix types. CAHFS personnel are highly experienced in handling many types of method development projects. The section has worked collaboratively with the FDA to develop and validate a number of methods in the past and has had notable success in rapid method development in response to emergencies in the food supply. As part of this project, CAHFS has proposed a specific method development project for each of the five years covered by the grant. The methods proposed are intended to increase our ability to detect human food and animal feed contamination and prevent those commodities from injuring humans or animals. In summary, funding from this grant will allow CAHFS to continue to serve as a valued partner to the FDA in the exploration and development of new analytical chemistry methods and technologies.

学科D轨道3：方法开发和方法验证 项目摘要 FDA对化学分析的利用对该机构保护美国食品供应的能力至关重要 不安全的化学污染。不断需要新的分析方法， 技术，以应对新的食品基质所带来的挑战，并有效利用新的 更高效的分析技术。该项目的目的是为以下方面提供资金： 对新的分析方法进行初步研究，将方法扩展到新的食品基质， 多实验室研究。 加州动物健康和食品安全实验室（CAHFS）的毒理学部门 在方法开发和推广项目以及新方法评估方面有丰富的经验。 技术.兽医分析毒理学的性质是这样的，有恒定的要求， 新方法的开发。这些方法中的一些需要处理 而其他的则被设计成长期使用的常规方法。的能力 执行这些发展项目是该科确保儿童健康的使命的组成部分， 加州的农业动物及其饲料安全。 该科维持各种不同类型的仪器，以便在分析 检测和分析各种矩阵类型的能力。CAHFS人员高度 在处理多种方法开发项目方面经验丰富。这一节起了作用 与FDA合作开发和验证了许多方法，并已 在应对粮食供应紧急情况的快速方法开发方面取得了显著成功。的一部分 在这个项目中，CAHFS为五年中的每一年提出了一个具体的方法开发项目 由赠款支付。提出的方法旨在提高我们检测人类食物的能力 和动物饲料污染，并防止这些商品伤害人或动物。 总之，这笔赠款的资金将使CAHFS继续作为一个有价值的合作伙伴， FDA在探索和开发新的分析化学方法和技术。