Diagnostic toxicology support for VetLIRN

项目摘要/摘要 这项提案的目的是描述我们的实验室参与FDA 兽医实验室信息响应网络(VetLIRN)。这项建议 描述我们计划如何为毒理学分析提供分析支持 动物组织、饲料、食物和其他关注的基质 可能危及我国安全的化学污染事件 动物性食品供应或牲畜、同伴动物或人的健康和安全。 我们建议在需要时参与开发和扩展分析工具 旨在筛选各种基质的方法，以发现各种和潜在的有害物质 化学品，包括未知化合物，使用GC/MS、LC/MS、ICP/MS和其他 分析方法。实验室人员将参加训练演习 旨在评估VetLIRN应对监视、紧急情况的能力 应对和恢复情况，参加国家和区域会议，并协助 随着化学分析方法的发展和验证 污染物。 具体目标包括： 对实验室人员进行分析毒理学方法学方面的培训 VetLIRN 提供分析专业知识，以改进、扩展和验证 现有的VetLIRN毒理学方法 协助开发VetLIRN AS的新毒理学方法 需要 参与VetLIRN能力测试计划 与其他VetLIRN成员实验室合作以确保有效性 VetLIRN计划的 参与案件调查、动物饲料监测、紧急情况 响应，或在需要时进行恢复工作 通过使用VetLIRN与其他实验室进行有效沟通 ELEXNET

Project Summary/Abstract The objective of this proposal is to describe our laboratory's involvement in the FDA Veterinary Laboratory Information Response Network (VetLIRN). This proposal describes how we plan to provide analytical support for the toxicological analysis of animal tissues, feeds, foods, and other matrices of concern in the event that there is a chemical contamination incident that potentially compromises the safety of our nation's animal food supply or the health and safety of livestock, companion animals, or people. We propose to participate, as needed, in the development and expansion of analytical methods designed to screen a variety of matrices for diverse and potentially harmful chemicals, including unknown compounds, using GC/MS, LC/MS, ICP/MS, and other analytical methodologies. Laboratory personnel will participate in training exercises designed to assess the ability of VetLIRN to respond to surveillance, emergency response, and recovery scenarios, participate in national and regional meetings, and assist with the development and validation of methods for the analysis of chemical contaminants. Specific objectives include:  training of laboratory personnel in analytical toxicology methodologies needed by the VetLIRN  provision of analytical expertise to the improvement, expansion, and validation of existing VetLIRN toxicology methods  assistance with the development of new toxicology methods for the VetLIRN as needed  participation in VetLIRN proficiency testing programs  collaboration with other VetLIRN member laboratories to ensure the effectiveness of the VetLIRN program  participation in case investigations, animal feed surveillance, emergency response, or recovery exercises as the need arises  effectively communicating with other VetLIRN laboratories via the use of eLEXNET