CAHFS Animal Feed Testing; Discipline B Track 3; 7/1/2020-6/30/2021

学科B轨道3：动物食品产品测试 项目摘要 美国食品和药物管理局是负责确保美国境内动物食品安全的机构。 该项目的目的是让赠款接受者通过以下方式协助改进监测方案： 动物食品的化学检测。作为加州的州兽医诊断实验室， 加州动物健康和食品安全实验室（CAHFS）将帮助实现项目目标。 CAHFS通过与州监管机构合作促进动物食品保护， 负责执行动物食品安全法规。CAHFS毒理学部门 承诺与加州农业部（CDFA）签订合同协议 商业饲料监管计划（CFRP）开始为其饲料提供分析服务， 今年7月，食品安全。CDFA管理动物饲料监管计划 加州州标准（AFRPS）。一旦合同到位，CAHFS将是主要的 在加州州内对动物食品进行安全测试的服务实验室。 虽然CDFA CFRP计划对CAHFS来说是新的，但我们预计监管的无缝整合 饲料检测纳入我们的诊断检测工作量，因为许多所需的饲料检测SOP已经 到位这笔拨款将加强我们的监管测试，同时改善FDA对 美国最大的农业州之一的动物食品系统 我们计划收集100头奶牛饲料样品，包括全玉米和全棉籽。半年 将对这些样本进行霉菌毒素检测，另一半样本将进行必需和非必需金属检测。的 我们计划使用的方法包括由FDA-CFSAN人员开发的真菌毒素筛选（Zhang et. （见上文）以及FDA官方方法CHE.0009。 违反或“不能排除”的CRO霉菌毒素水平将由指导水平确定 在FDA的CVM年度报告中发表2016财年动物食品中的真菌毒素报告 （FY16）。必需和非必需金属最大耐受浓度（MTC）由 国家研究理事会在“动物的矿物质耐受性”第二版中，2005年将用于指导 监管行动。超过这些指南的结果将按照本指南的要求报告给FDA。 格兰特. 我们相信，我们将能够容纳更多的样本数量在这个测试轨道在第2年 在这五年的时间里，我们还希望在2010年签署更多的样本收集协议。 这将使我们能够分析额外的商品/危险配对。

Discipline B Track 3: Animal Food Product Testing Project Summary The U.S. FDA is the agency responsible for assuring the safety of animal food within the U.S. The purpose of this project is for grant recipients to assist in improving surveillance programs through chemical testing of animal food products. As California’s state veterinary diagnostic laboratory, the California Animal Health and Food Safety Laboratory (CAHFS) is set to help meet the project goals. CAHFS promotes animal food protection by working in partnership with state regulatory agencies that have the responsibility for enforcing animal food safety regulations. The CAHFS Toxicology Section has committed to enter into a contractual agreement with the California Department of Agriculture (CDFA) Commercial Feed Regulatory Program (CFRP) to begin providing analytical services for their feed and food safety program in July of this year. CDFA administers the Animal Feed Regulatory Program Standards (AFRPS) for the State of California. Once a contract is in place, CAHFS will be the primary servicing laboratory for the safety testing of manufactured animal food within the State of California. While the CDFA CFRP program is new to CAHFS, we anticipate the seamless integration of regulatory feed testing into our diagnostic testing workload since many of the needed feed testing SOPs are already in place. This grant will enhance our regulatory testing while improving the FDA’s surveillance of the animal food system in one of the country’s largest agricultural states We plan to collect 100 dairy cattle feed samples consisting of whole corn and whole cottonseed. Half of those samples will be tested for mycotoxins, the other half for essential and non-essential metals. The methods we plan on using include a mycotoxin screen developed by FDA-CFSAN personnel (Zhang et. al.) and the official FDA method CHE.0009 for metals. Violative or “cannot-rule-out” CRO mycotoxin levels will be determined by the guidance levels published in the FDA’s CVM Annual Report on Mycotoxins in Animal Food Report for Fiscal Year 2016 (FY16). The essential and non-essential metal maximum tolerable concentrations (MTC) published by the National Research Council in “Mineral Tolerance of Animals” 2nd Ed., 2005 will be used to guide regulatory actions. Results exceeding these guidelines will be reported to the FDA as required by this grant. We believe that we will be able to accommodate larger sample numbers in this testing track in years 2 through 5 of this FERN grant period. We also expect to have additional sample collection agreements in place that will allow us to analyze additional commodity/hazard pairings.