Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
免疫肿瘤学翻译网络:RPCI 的数据管理和资源共享中心
基本信息
- 批准号:10175779
- 负责人:
- 金额:$ 84.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2021-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAtlas of Cancer Mortality in the United StatesAwarenessBioconductorBioinformaticsBiometryBiostatistics Shared ResourceBuffaloesCancer Center Support GrantCatalogsClinicalCollaborationsCombined Modality TherapyCommunicationCommunitiesComprehensionComprehensive Cancer CenterComputer softwareComputing MethodologiesDataData AnalysesData AnalyticsData Management ResourcesDatabasesDependenceDevelopmentDrug KineticsDrug resistanceEducation and OutreachEnsureFosteringFundingGoalsHandImmunooncologyImmunotherapyInformaticsInformation TechnologyInfrastructureIntranetLogisticsMalignant NeoplasmsManuscriptsMethodsMultiomic DataOncologyPerformancePoliciesPositioning AttributePreparationPrincipal InvestigatorProceduresProductivityPubMedRecordsReproducibilityResearchResearch DesignResearch PersonnelResearch Project GrantsResistanceResource SharingResourcesSupercomputingSystemTextTraining and EducationTranslationsUnited States National Institutes of HealthUniversitiesanti-cancer therapeuticbiobankbioinformatics toolcancer therapycombatdata harmonizationdata integrationdata managementdata sharingdata toolsdata warehousedesigndrug sensitivityexpectationexperiencehigh standardimprovedinnovationinterestmembermetabolomicsmultidisciplinarymultiple omicsopen sourceoperationoutreachpredictive markerprotocol developmentquality assurancereal time monitoringresistance mechanismresponsesocial mediastructured datasupport networktranslational studytumorweb portal
项目摘要
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-
20-052.
Project Summary
While several innovative and creative anti-cancer therapies have shown promising results, a significant
expansion of their clinical use will require collaborative efforts to elucidate resistance mechanisms, exploit tumor
sensitivity, map cancer dependence, discover new targets, identify predictive biomarkers, evaluate combination
therapies, and develop real-time monitoring approaches. Leveraging cutting-edge multi-disciplinary team
approaches, we will support the NCI Drug Resistance and Sensitivity Network (DRSN) to understand and combat
mechanisms of tumor resistance and to exploit tumor sensitivity to anti-cancer therapies. Our strategy is to serve
as an administration, communication, collaboration and analysis hub to coordinate the DRSN’s network-wide
studies, focusing on reducing barriers to domain expertise, improving the productivity of DRSN investigators,
maintaining a high standard for data harmonization and integration, designing and implementing rigorous
analytical strategies, and fostering a collaborative and supportive research community.
An experienced, multidisciplinary team has been assembled to pursue five Specific Aims: First, we will provide
a centralized administration infrastructure to coordinate DRSN activities, building upon the Immuno-Oncology
Translational Network (IOTN) Data Management and Resource-sharing Center (DMRC)’s well-functioning
infrastructure that currently coordinates network studies under the umbrella of the NCI Cancer Moonshot
initiative. Second, we will actively promote the DRSN and foster trans-consortium interactions, where we will
leverage the IOTN DMRC’s demonstrable experience in Cross-Moonshot outreach and Bioconductor’s
decades-long record in community-wide engagement. Third, we will provide multidisciplinary expertise to
support DRSN collaborative research, leveraging four of the Roswell Park CCSG’s shared resources:
Biostatistics, Bioinformatics, Data Bank and BioRepository, Bioanalytics, Metabolomics & Pharmacokinetics. Our
analytic support will be armed with professional IT staff and informed by an experienced anti-cancer therapeutic
researcher team. Fourth, we will develop innovative multi-omics data integration methods to enhance DRSN’s
research capacity, capitalizing on the well-respected and highly-successful Bioconductor project. Fifth, we will
disseminate resources developed in the DRSN to the broader community, unleashing the full potential of DRSN
activities. Taken together, we envision our CC, in close collaboration with the DRSN components, will allow us
to conduct highly effective and innovative translational studies to address the significantly unmet needs related
to anti-cancer therapeutics, and fulfill the expectations and guiding principles of NCI Cancer Moonshot initiative.
本申请是根据非ca -特殊利益通知(NOSI)提交的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alan David Hutson其他文献
Alan David Hutson的其他文献
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{{ truncateString('Alan David Hutson', 18)}}的其他基金
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
免疫肿瘤学翻译网络:RPCI 的数据管理和资源共享中心
- 批准号:
10872397 - 财政年份:2023
- 资助金额:
$ 84.1万 - 项目类别:
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
免疫肿瘤学翻译网络:RPCI 的数据管理和资源共享中心
- 批准号:
10558158 - 财政年份:2022
- 资助金额:
$ 84.1万 - 项目类别:
Data and Resource Coordination Center for Cancer Prevention-Interception Targeted Agent Discovery Program
癌症预防拦截靶向药物发现计划数据和资源协调中心
- 批准号:
10796105 - 财政年份:2022
- 资助金额:
$ 84.1万 - 项目类别:
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
免疫肿瘤学翻译网络:RPCI 的数据管理和资源共享中心
- 批准号:
10230774 - 财政年份:2020
- 资助金额:
$ 84.1万 - 项目类别:
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
免疫肿瘤学翻译网络:RPCI 的数据管理和资源共享中心
- 批准号:
10045426 - 财政年份:2019
- 资助金额:
$ 84.1万 - 项目类别:
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
免疫肿瘤学翻译网络:RPCI 的数据管理和资源共享中心
- 批准号:
10175624 - 财政年份:2018
- 资助金额:
$ 84.1万 - 项目类别:
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
免疫肿瘤学翻译网络:RPCI 的数据管理和资源共享中心
- 批准号:
10455318 - 财政年份:2018
- 资助金额:
$ 84.1万 - 项目类别:
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI
免疫肿瘤学翻译网络:RPCI 的数据管理和资源共享中心
- 批准号:
10800071 - 财政年份:2018
- 资助金额:
$ 84.1万 - 项目类别: