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Core B: Biostatistics and Informatics

核心 B：生物统计学和信息学

基本信息

批准号：
10362705
负责人：
Alan David Hutson
金额：
$ 16.44万
依托单位：
ROSWELL PARK CANCER INSTITUTE CORP
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-03 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10362705
关键词：
Address Attention Award Basic Science Bioinformatics Biometry Clinical Clinical Protocols Clinical Sciences Clinical Trials Clinical Trials Design Collaborations Communities Computer software Data Data Analyses Data Collection Dedications Electronic Mail Ensure Experimental Designs Faculty Formulation Fostering Funding Goals Immunooncology Immunotherapy Individual Informatics Infrastructure Lead Malignant Neoplasms Manuscripts Methodology Modeling Outcome Privacy Procedures Process Production Productivity Progress Reports Protocol Compliance Reporting Research Research Personnel Resources Role Services System Techniques Telephone Translational Research Tumor Tissue Update Work bioimaging chemokine data management data modeling data quality data sharing data sharing networks design high standard improved innovation meetings member novel pathology imaging programs symposium translational oncology tumor web site

项目摘要

Appropriate analytic techniques and careful data management are essential components of all studies, to ensure that valid inferences will be made. Core B (Biostatistics and Informatics Core) will ensure that both Biostatistics and Informatics data management design and modeling support is readily available to all project leaders and staff of the P01 "Targeting the Chemokine System to Sensitize Tumors to Immunotherapy". We will assist basic, translational and clinical researchers involved in the P01 with proper formulation, refinement and execution of study objectives by applying the appropriate Biostatistics and Informatics analyses, and providing the appropriate interpretation of their results, in terms of both strengths and limitations. This includes developing the appropriate statistical design for the clinical trials of this highly translational P01, which involves with six clinical trials. We will work to ensure that appropriate data are collected; the data are of the highest quality and meet regulatory standards for privacy; and that the data are those required to answer a study question, necessary for administrative reporting, needed to establish protocol compliance, and/or will be included in the resulting manuscripts. The Core has the ability to develop and implement novel and innovative statistical and bioinformatics methodology, as needed, to address all study objectives. It is anticipated that the services of Core B will be extensively used by all researchers associated with the P01. Benefits of Core B include providing a consistent team across projects dedicated to efficient collaboration.

适当的分析技术和仔细的数据管理是所有研究的重要组成部分，以确保做出有效的推论。核心B(生物统计和信息学核心)将确保生物统计学和信息学数据管理设计和建模支持随时可用于所有项目 P01“靶向趋化因子系统，使肿瘤对免疫疗法敏感”的领导和工作人员。我们将协助参与P01的基础、翻译和临床研究人员进行适当的制定、改进通过应用适当的生物统计学和信息学分析来实现研究目标，以及从优势和局限性两个方面对他们的结果进行适当的解释。这包括为这一高度翻译的P01的临床试验制定适当的统计设计，其中包括有六项临床试验。我们将努力确保收集适当的数据；这些数据是最高的质量并符合隐私监管标准；这些数据是回答研究所需的数据行政报告所必需的问题，需要建立协议遵从性，和/或将包括在最终的手稿中。核心具有开发和实施新颖创新的能力根据需要，采用统计和生物信息学方法，以解决所有研究目标。据预计，核心B的服务将被与P01相关的所有研究人员广泛使用。酷睿B的优势包括在致力于高效协作的项目中提供一致的团队。