Data and Resource Coordination Center for Cancer Prevention-Interception Targeted Agent Discovery Program

癌症预防拦截靶向药物发现计划数据和资源协调中心

• 批准号: 10796105
• 负责人: Alan David Hutson
• 金额: $ 77.12万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10796105
• 关键词: Acceleration; Address; Adopted; Bioconductor; Bioinformatics; Biometry; Cancer Center; Cancer Center Support Grant; Catalogs; Characteristics; Collaborations; Communities; Comprehension; Computer software; Data; Data Analyses; Data Coordinating Center; Data Science; Databases; Development; Ecosystem; Ensure; Fostering; Funding; Goals; Hand; Immune Targeting; Immunooncology; Immunotherapy; Informatics; Information Technology; Infrastructure; Intercept; Malignant Neoplasms; Methods; Molecular Target; Multiomic Data; National Human Genome Research Institute; Oncogenic; Police; Policies; Principal Investigator; Process; Productivity; PubMed; Records; Reproducibility; Research; Research Personnel; Research Project Grants; Resistance; Resource Sharing; Resources; Risk; Services; Text; United States National Institutes of Health; Visualization; biomedical informatics; cancer prevention; central database; cloud based; community engagement; data acquisition; data ecosystem; data harmonization; data integration; data management; data sharing; data sharing networks; data standards; design; experience; genomic data; high risk population; improved; innovation; interest; interoperability; multidisciplinary; open source; operation; outreach; pre-clinical; precision cancer prevention; prevent; programs; quality assurance; response; support network; targeted agent; therapy resistant; tool; translational oncology; translational study; tumor progression; virtual

Project Summary/Abstract: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-23-012. The goal of our proposed Data and Resource Coordinating Center (DRCC) application is to coordinate the activities across the Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT), and to manage, integrate and disseminate the data and resources generated through the network. Leveraging cutting-edge multi-disciplinary team approaches, we will support the CAP-IT to discover molecularly or immunologically targeted agents designed to prevent or intercept the oncogenic process for precision cancer prevention and interception. Our strategy is to enhance the productivity of CAP-IT investigators by fostering a collaborative and synergistic research community, accelerate the progress of CAP- IT research by reducing barriers to accessing analytics expertise, ensure the reproducibility of CAP-IT data by deploying best practices for data acquisition and harmonization, and unleash the full potential of CAP-IT activities by developing enhanced tools to enable resource sharing to the broader scientific community. First, we will provide a centralized administrative infrastructure to coordinate CAP-IT activities, building upon our well-functioning infrastructure that currently coordinates network studies under the umbrella of the NCI Cancer Moonshot initiatives. Second, we will actively promote the CAP-IT and engage in trans-consortium interactions, where we will leverage our demonstrable experience in Cross-Moonshot outreach and Bioconductor’s decades-long record in community engagement. Third, we will, in coordination with each CAP- IT center’s informatics group, provide multidisciplinary analytics expertise to support CAP-IT’s collaborative research, leveraging three of Roswell Park CCSG’s shared resources: Biostatistics, Bioinformatics, Biomedical Informatics. Fourth, we will develop improved data integration and analysis software, database and workflows to enhance CAP-IT’s research capacity, capitalizing on our extensive track-record in developing NIH-supported Cancer Moonshot, Bioconductor and AnVIL ecosystems. Taken together, we envision that our DRCC, in close collaboration with the CAP-IT U54 Centers and NCI staffs, will allow us to support highly effective and innovative translational studies to address the significantly unmet needs related to precision cancer prevention-interception. The main deliverables from the proposed aims will be administrative and outreach support to coordinate network activities, facilitate network collaboration, and engage in interaction with the broader community (Aim 1); workflows to ensure that all data generated by the CAP-IT will be harmonized using standards interoperable with the broader cancer data ecosystem, analysis tools and database to integrate CAP-IT data and facilitate cross-study analysis, and multidisciplinary analytics supports to accelerate CAP-IT research progress (Aim 2); polices and infrastructures to ensure that all resources generated by the CAP-IT will be findable in a centralized virtual information hub, and that all resources will be shared with the broader scientific community (Aim 3).

项目摘要/摘要：本申请是应特别通知提交的 利息(NOSI)标识为NOT-CA-23-012。我们提议的数据和资源协调中心的目标是 (DRCC)的应用是协调整个癌症预防-拦截靶向剂的活动 发现计划(CAP-IT)，并管理、整合和传播产生的数据和资源 通过网络。利用前沿的多专业团队方法，我们将支持CAP-IT 发现分子或免疫靶向药物，旨在阻止或拦截致癌过程 用于精准的癌症预防和拦截。我们的战略是提高CAP-IT的生产力 研究人员通过培育一个协作和协同的研究社区，加快履约协助方案的进展- IT研究通过减少获取分析专业知识的障碍，通过以下方式确保CAP-IT数据的可重复性 部署数据获取和协调的最佳做法，并充分发挥履约协助方案--信息技术活动的潜力 通过开发增强的工具，使更广泛的科学界能够共享资源。 首先，我们将提供一个集中的管理基础设施来协调CAP-IT活动，建立 依靠我们运行良好的基础设施，目前在NCI的保护伞下协调网络研究 癌症登月计划。第二，我们将积极推动CAP-IT，参与跨联合体 互动，我们将利用我们在跨月球拍摄方面的明显经验和 生物导体数十年来在社区参与方面的记录。第三，我们将与每个履约协助方案协调- IT中心的信息学小组，提供多学科分析专业知识，以支持CAP-IT的协作 研究，利用Roswell Park CCSG的三个共享资源：生物统计学、生物信息学、生物医学 信息学。第四，我们将开发改进的数据集成和分析软件、数据库和工作流程，以 增强CAP-IT的研究能力，充分利用我们在开发NIH支持的产品方面的广泛记录 巨蟹座登月，生物导体和铁锤生态系统。综上所述，我们设想我们的DRCC，在接近 与CAP-IT U54中心和NCI工作人员的合作将使我们能够支持高效和创新 翻译研究，以解决与精确癌症预防-截取相关的显著未得到满足的需求。 拟议目标的主要交付成果将是行政和外联支助，以协调 网络活动，促进网络协作，并与更广泛的社区进行互动(AIM 1)；确保履约协助方案--IT部门产生的所有数据将使用可互操作的标准进行协调的工作流程 借助更广泛的癌症数据生态系统、分析工具和数据库来集成CAP-IT数据并促进 交叉研究分析和多学科分析支持，以加快履约协助方案--信息技术研究进展(目标2)； 策略和基础设施，以确保CAP-IT生成的所有资源都可以在集中的 将建立虚拟信息中心，并与更广泛的科学界共享所有资源(目标3)。