High Field MRI For Optimized Translational 1H Multiparametric and Multinuclear Imaging Research

项目摘要/摘要 提议更换一个独特的但老化的、商业上没有支持的、仅有鼠标的垂直孔瓦里安 14T临床前MRI到最先进的Bruker 9.4T横孔MRI扫描仪，大小足以供小鼠和 RATS被23个目前资助的项目(NIH资助的21个项目)在翻译和临床方面的研究需求证明是合理的 加州大学旧金山分校和国际上通过NIH P41支持的超极化磁共振进行的生物医学研究 技术资源中心。这项S10 HeI奖对于更换老化的临床前MRI至关重要 通过解决目前资金和新研究项目面临的限制，达到最先进的水平。此应用程序是 得到了强大的机构支持，涵盖了9.4T磁共振扫描仪三分之一的成本和选址，以及 需要的理由不仅包括强有力的研究支持，而且还包括实质性的培训，良好的 通过加州大学旧金山分校研究资源计划(RRP)的临床前建立管理基础设施 成像核心，以及加州大学旧金山分校超极化磁共振技术资源中心(HMTRC)。RRP核心和 HMTRC提供经验丰富的技术支持、培训、专家人员、附属设备和 用于传播成果/技术的基础设施，以使这一主要的高端仪器项目 成功地实现了向校内和校外用户提供最先进的仪器设备的目标。 UCSF RRP临床前成像核心，将安装9.4T磁共振成像，提供先进的临床前 成像仪器包括4台扫描仪、2台DNP偏光片、其他辅助小型设备、湿实验室 为整个加州大学旧金山分校提供翻译临床前影像研究的设施和专家人员。 具体地说，临床前成像核心服务于广泛的研究和临床社区(50名校长 医学院和药学学院的研究人员)，并支持广泛的基础和临床 研究(肿瘤学、糖尿病、心脏病、脑部疾病、肝病、传染病和药物 发现)。这些设备将用于培训加州大学旧金山分校的大量学生，无论是作为正式的 研究生课程或研究项目。此外，这一工具还将用于培训来自 通过加州大学旧金山分校超极化核磁共振技术资源中心和初级教员在世界各地 由放射学和生物医学成像部提供支持。新的临床前核磁共振将提供 通过提供更大型啮齿动物的能力，提供急需的、扩展的临床前磁共振成像功能 研究，并通过使用硬件增强来进入令人兴奋的新方向，如氘和 磷光谱成像研究。 综上所述，设备更换S10计划对于消除限制临床前应用的主要瓶颈至关重要 核磁共振研究，还将有利于加州大学旧金山分校的学生和全国以及 在国际上，通过动手讲习班、个人访问、网络会议、网站传播和 协作性多站点研究。

Project Summary/Abstract The proposed replacement of a unique but aging, commercially unsupported, mouse only vertical bore Varian 14T pre-clinical MRI to a state-of-the-art Bruker 9.4T horizontal bore MRI scanner large enough for mice and rats is justified by the research needs of 23 currently funded projects (21 NIH grants) in translational and clinical biomedical research at UCSF and internationally through the NIH P41 supported Hyperpolarized MRI Technology Resource Center. This S10 HEI award is critical to enable the replacement of aging pre-clincial MRI to state-of-the-art, by addressing current limitations facing funded and new research projects. This application is supported by strong institutional support covering ≈ 1/3 of the cost and siting of the 9.4T MRI scanner, and a Justification of Need which not only includes strong research support but also substantial training, a well- established administrative infrastructure through the UCSF Research Resource Program’s (RRP) Pre-clinical Imaging Core, and the UCSF Hyperpolarized MRI Technology Resource Center (HMTRC). The RRP core and HMTRC provide the highly experienced technical support, training, expert personnel, ancillary equipment and infrastructure for dissemination of results/techniques to make this major high-end instrumentation project optimally successful in its goal to provide state-of-the-art instrumentation to both intra- and extramural users. The UCSF RRP Pre-Clinical Imaging Core, where the 9.4T MRI will be sited, provides advanced pre-clinical imaging instrumentation consisting of 4 scanners, 2 DNP polarizers, other supporting small equipment, wet lab facilities, as well as expert personnel for translational pre-clinical imaging research for the entire UCSF campus. Specifically, the Pre-clinical Imaging Core serves a broad research and clinical community (50+ Principal Investigators in the Schools of Medicine and Pharmacy) and supports a broad spectrum of basic and clinical research (oncology, diabetes, cardiac disease, brain disorders, liver disease, infectious diseases and drug discovery). The equipment will be used for training a large number of students at UCSF either as part of formal graduate courses or research projects. Furthermore, this instrument will also be used to train investigators from around the world through the UCSF Hyperpolarized MRI Technology Resource Center as well as junior faculty supported by the Department of Radiology and Biomedical Imaging. The new pre-clinical MRI will provide critically-needed, expanded pre-clinical MR imaging capabilities by providing the ability to do larger rodent studies, and by using hardware enhancements to go in exciting new directions such as deuterium and phosphorus spectroscopic imaging studies. In summary, this equipment replacement S10 proposal is critical to remove a major bottleneck limiting pre-clinical MRI research and will also benefit the training of students at UCSF and external investigators nationally and internationally through hands-on workshops, individual visits, web-conferences, website dissemination, and collaborative multi-site research.