High Field MRI For Optimized Translational 1H Multiparametric and Multinuclear Imaging Research

用于优化平移 1H 多参数和多核成像研究的高场 MRI

• 批准号: 10175910
• 负责人: John Kurhanewicz
• 金额: $ 200万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2024-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175910
• 关键词: 2,4-Dinitrophenol; Address; Aging; Award; Basic Science; Biomedical Research; Brain Diseases; Clinical; Clinical Research; Communicable Diseases; Communities; Deuterium; Diabetes Mellitus; Educational workshop; Equipment; Extramural Activities; Funding; Goals; Grant; Heart Diseases; Human Resources; Image; Individual; Information Dissemination; Infrastructure; International; Internet; Liver diseases; Magnetic Resonance Imaging; Mus; Oncology; Pharmacy facility; Phosphorus; Principal Investigator; Rattus; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Site; Students; Techniques; Technology; Training; United States National Institutes of Health; Visit; bioimaging; cost; drug discovery; experience; faculty support; imaging capabilities; imaging study; instrument; instrumentation; investigator training; medical schools; pre-clinical; preclinical imaging; programs; radiological imaging; spectroscopic imaging; student training; symposium; web site

Project Summary/Abstract The proposed replacement of a unique but aging, commercially unsupported, mouse only vertical bore Varian 14T pre-clinical MRI to a state-of-the-art Bruker 9.4T horizontal bore MRI scanner large enough for mice and rats is justified by the research needs of 23 currently funded projects (21 NIH grants) in translational and clinical biomedical research at UCSF and internationally through the NIH P41 supported Hyperpolarized MRI Technology Resource Center. This S10 HEI award is critical to enable the replacement of aging pre-clincial MRI to state-of-the-art, by addressing current limitations facing funded and new research projects. This application is supported by strong institutional support covering ≈ 1/3 of the cost and siting of the 9.4T MRI scanner, and a Justification of Need which not only includes strong research support but also substantial training, a well- established administrative infrastructure through the UCSF Research Resource Program’s (RRP) Pre-clinical Imaging Core, and the UCSF Hyperpolarized MRI Technology Resource Center (HMTRC). The RRP core and HMTRC provide the highly experienced technical support, training, expert personnel, ancillary equipment and infrastructure for dissemination of results/techniques to make this major high-end instrumentation project optimally successful in its goal to provide state-of-the-art instrumentation to both intra- and extramural users. The UCSF RRP Pre-Clinical Imaging Core, where the 9.4T MRI will be sited, provides advanced pre-clinical imaging instrumentation consisting of 4 scanners, 2 DNP polarizers, other supporting small equipment, wet lab facilities, as well as expert personnel for translational pre-clinical imaging research for the entire UCSF campus. Specifically, the Pre-clinical Imaging Core serves a broad research and clinical community (50+ Principal Investigators in the Schools of Medicine and Pharmacy) and supports a broad spectrum of basic and clinical research (oncology, diabetes, cardiac disease, brain disorders, liver disease, infectious diseases and drug discovery). The equipment will be used for training a large number of students at UCSF either as part of formal graduate courses or research projects. Furthermore, this instrument will also be used to train investigators from around the world through the UCSF Hyperpolarized MRI Technology Resource Center as well as junior faculty supported by the Department of Radiology and Biomedical Imaging. The new pre-clinical MRI will provide critically-needed, expanded pre-clinical MR imaging capabilities by providing the ability to do larger rodent studies, and by using hardware enhancements to go in exciting new directions such as deuterium and phosphorus spectroscopic imaging studies. In summary, this equipment replacement S10 proposal is critical to remove a major bottleneck limiting pre-clinical MRI research and will also benefit the training of students at UCSF and external investigators nationally and internationally through hands-on workshops, individual visits, web-conferences, website dissemination, and collaborative multi-site research.

项目总结/摘要 建议更换一个独特的，但老化，商业上不支持，鼠标只垂直孔瓦里安 14 T临床前MRI到最先进的Bruker 9.4T水平孔MRI扫描仪，该扫描仪对于小鼠来说足够大， 大鼠是合理的研究需要23个目前资助的项目（21 NIH赠款）在转化和临床 UCSF和国际上通过NIH P41支持的超极化MRI的生物医学研究 技术资源中心。这项S10 HEI奖项对于取代老化的临床前MRI至关重要 国家的最先进的，通过解决目前面临的限制资助和新的研究项目。本申请是 在强大的机构支持下，9.4T MRI扫描仪的成本和选址均为1.1/3， 需要的理由，其中不仅包括强大的研究支持，但也大量的培训，一个良好的- 通过UCSF研究资源计划（RRP）建立了行政基础设施 成像核心和UCSF超极化MRI技术资源中心（HMTRC）。RRP核心和 HMTRC提供经验丰富的技术支持，培训，专家人员，辅助设备和 传播成果/技术的基础设施，使这一重大高端仪器项目 最佳成功的目标，提供国家的最先进的仪器内外用户。 加州大学旧金山分校RRP临床前成像核心，其中9.4T MRI将被定位，提供先进的临床前 成像仪器，包括4台扫描仪、2台DNP偏振器、其他辅助小型设备、湿实验室 设施，以及专家人员的翻译临床前成像研究为整个加州大学旧金山分校校园。 具体而言，临床前成像核心服务于广泛的研究和临床社区（50多个主要 医学和药学院的研究人员），并支持广泛的基础和临床 研究（肿瘤学、糖尿病、心脏病、脑部疾病、肝病、传染病和药物） discovery）。这些设备将用于培训大量的学生在加州大学旧金山分校或作为正式的一部分， 研究生课程或研究项目。此外，该工具还将用于培训调查人员， 通过UCSF超极化MRI技术资源中心以及初级教师在世界各地 由放射学和生物医学成像部门提供支持。新的临床前MRI将提供 通过提供对更大的啮齿类动物进行磁共振成像的能力， 研究，并通过使用硬件增强去在令人兴奋的新方向，如氘， 磷光谱成像研究。 总之，该设备更换S10提案对于消除限制临床前研究的主要瓶颈至关重要。 MRI研究，也将有利于在UCSF的学生和外部调查人员在全国范围内的培训， 在国际上，通过实践研讨会、个人访问、网络会议、网站传播， 多站点协作研究。