Research Network for the Harmonized Cognitive Assessment Protocol (HCAP)

协调认知评估协议（HCAP）研究网络

• 批准号: 10176339
• 负责人: KENNETH M LANGA
• 金额: $ 38.33万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176339
• 关键词: Address; Affect; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; Behavioral; Biological Markers; Communications Media; Consultations; Country; Data; Diagnostic; Diet; Elderly; Family Study; Funding; Genetic; Health and Retirement Study; International; Leadership; Life Cycle Stages; Longitudinal Studies; Measures; Pilot Projects; Policies; Population Study; Prevalence; Protocols documentation; Research; Research Personnel; Resources; Retirement; Risk; Sampling; Sampling Studies; Scientist; Sister; Site; Testing; Variant; Weight; cardiovascular risk factor; cognitive function; cognitive testing; comparative; data harmonization; design; epidemiology study; flexibility; instrument; meetings; population based; response; social; web site; working group

PROJECT SUMMARY The Harmonized Cognitive Assessment Protocol (HCAP) was designed by the HRS in consultation with several of its international sister studies to provide a flexible but comparable instrument for measuring cognitive function among older adults around the world. This application seeks to establish a research network to support the continued harmonization of the HCAP studies. Our first priority will be harmonization among the nine studies currently funded to conduct the HCAP, with our second priority advising the additional studies developing plans to do so. Planned harmonization activities span the full life-course of such studies from sample design, to content and administration of the protocol, to statistical harmonization of data collected, to diagnostic algorithms, to covariates for epidemiological research, including biomarkers and genetics. While achieving harmonization in established studies requires active participation of senior leadership, we also aim to develop younger scholars through their participation and exchanges among the studies. Building an international network of studies of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) within an existing network of population-based longitudinal studies of aging creates unique research opportunities to exploit cross-country variation in key life-course factors that likely affect cognitive function and the risk for AD, such as educational attainment, wealth, retirement policies, diet, and the prevalence and treatment of cardiovascular risk factors. However, cross-country variations also raise unique challenges for maintaining the harmonization of tests and measures necessary for good comparative research. Our proposed international network will directly address these harmonization challenges. In addition to the exchange of information through meetings and other forms of communication, the network will support pilot projects that conduct analysis aimed at answering important questions for how to better harmonize the studies to one another and to other studies around the world.

项目总结 协调认知评估协议(HCAP)是由HRS与 它的几项国际姊妹研究为测量认知能力提供了一种灵活但可比的工具 在世界各地的老年人中发挥作用。本申请旨在建立一个研究网络，以 支持继续协调HCAP研究。我们的首要任务将是协调 目前有九项研究获资助进行核心能力评估，我们的第二优先工作是为其他研究提供意见。 正在制定这样做的计划。计划中的协调活动跨越这类研究的整个生命周期， 样本设计、议定书的内容和管理、收集的数据的统计协调、 从诊断算法到流行病学研究的协变量，包括生物标志物和遗传学。而当 实现既定研究的协调需要高级领导层的积极参与，我们的目标也是 通过他们的参与和研究之间的交流，培养年轻的学者。 构建阿尔茨海默病和阿尔茨海默病相关国际研究网络 现有的基于人口的老龄化纵向研究网络中的痴呆(AD/ADRD)造成 独一无二的研究机会，利用可能影响生命历程的关键因素的跨国差异 认知功能和AD的风险，如教育程度、财富、退休政策、饮食和 心血管危险因素的流行和治疗。然而，越野变化也带来了独特的 保持测试协调的挑战，以及良好比较研究所需的措施。 我们提议的国际网络将直接应对这些协调挑战。除 通过会议和其他形式的通信交流信息，该网络将支持试点 进行分析的项目，旨在回答如何更好地协调研究的重要问题 相互之间，以及世界各地的其他研究。