Research Network for the Harmonized Cognitive Assessment Protocol (HCAP)

项目摘要 协调认知评估方案（HCAP）是由HRS与 它的几个国际姐妹研究提供了一个灵活的，但可比的工具，测量认知 在世界各地的老年人中发挥作用。本申请旨在建立一个研究网络， 支持HCAP研究的持续协调。我们的第一优先事项将是协调 目前有9项研究获得资助，以进行HCAP，我们的第二优先事项是为其他研究提供咨询意见 制定这样做的计划。计划的协调活动涵盖此类研究的整个生命周期， 样本设计、方案的内容和管理、所收集数据的统计协调， 诊断算法，流行病学研究的协变量，包括生物标志物和遗传学。而 实现既定研究的协调需要高层领导的积极参与，我们还旨在 通过青年学者的参与和学术交流，培养青年学者。 建立阿尔茨海默病和阿尔茨海默病相关研究的国际网络 痴呆症（AD/ADRD）在现有的基于人口的老龄化纵向研究网络中， 独特的研究机会，利用跨国变化的关键生命过程因素，可能影响 认知功能和AD的风险，如教育程度，财富，退休政策，饮食， 心血管危险因素的患病率和治疗。然而，跨国差异也提出了独特的 保持良好的比较研究所需的测试和措施的协调一致方面的挑战。 我们提议的国际网络将直接应对这些协调挑战。除了有 通过会议和其他通信形式交流信息，该网络将支持试点 进行分析的项目，旨在回答如何更好地协调研究的重要问题 以及世界各地的其他研究。

PROJECT SUMMARY The Harmonized Cognitive Assessment Protocol (HCAP) was designed by the HRS in consultation with several of its international sister studies to provide a flexible but comparable instrument for measuring cognitive function among older adults around the world. This application seeks to establish a research network to support the continued harmonization of the HCAP studies. Our first priority will be harmonization among the nine studies currently funded to conduct the HCAP, with our second priority advising the additional studies developing plans to do so. Planned harmonization activities span the full life-course of such studies from sample design, to content and administration of the protocol, to statistical harmonization of data collected, to diagnostic algorithms, to covariates for epidemiological research, including biomarkers and genetics. While achieving harmonization in established studies requires active participation of senior leadership, we also aim to develop younger scholars through their participation and exchanges among the studies. Building an international network of studies of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) within an existing network of population-based longitudinal studies of aging creates unique research opportunities to exploit cross-country variation in key life-course factors that likely affect cognitive function and the risk for AD, such as educational attainment, wealth, retirement policies, diet, and the prevalence and treatment of cardiovascular risk factors. However, cross-country variations also raise unique challenges for maintaining the harmonization of tests and measures necessary for good comparative research. Our proposed international network will directly address these harmonization challenges. In addition to the exchange of information through meetings and other forms of communication, the network will support pilot projects that conduct analysis aimed at answering important questions for how to better harmonize the studies to one another and to other studies around the world.