Neuroscience of Aging, Neurodegeneration and Alzheimer’s Disease

项目总结 美国人口普查局的人口预测表明，大约20%的人口将是65岁 到2030年老龄化，如果正确的话，这种人口结构变化将对中国的经济和健康产生重大影响 我们的国家。然而，人类正常衰老和病理性衰老的机制仍然很差。 了解，特别是与神经系统有关的那些，安全有效的治疗方法尚未 被开发出来。因此，这个T32项目的主要目标是为学生提供基本的、翻译的、 以及衰老和神经退行性变神经科学方面的临床研究培训。根据经验 在我们的20名教职员工中，之前培养了60名博士后学生和120名博士后研究员， 我们预计在此期间将培训12名博士生和8名博士后研究员 建议的5年资助期。因此，我们的计划预计将对国家 努力确保在接下来的几十年里有足够数量的训练有素的研究人员， 拥有正常和病理性人类衰老方面的专业知识。重要的是，我们的程序不会复制任何其他 OHSU的培训计划，这是学生获得综合研究的唯一机制 太平洋西北地区衰老和神经退行性变神经科学培训。 T32培训教员为俄勒冈州健康和科学中心带来了约2000万美元的直接研究资金 大学(OHSU)每年支持基础、翻译和临床衰老/神经变性研究。 此外，在医学院和工程学院中，教员有主要的任命， 俄勒冈州职业健康科学研究所(OIOHS)莱顿老龄化和阿尔茨海默氏症中心， Vollum研究所、高级成像研究中心(AIRC)、荣格神经科学中心 俄勒冈州国家灵长类动物研究中心(ONPRC)。因此，我们的计划提供培训 使用广泛的动物模型，包括无脊椎动物、啮齿类动物和非人类灵长类动物，以及 人类。它还提供广泛的研究核心支持和访问广泛的尖端技术 资源和方法，包括光谱一端的先进活体脑成像和RNA- 另一种是SEQ基因表达谱。目前，该计划与老龄化相关的主要研究重点领域 包括：昼夜节律紊乱，神经内分泌相关障碍，认知衰退，运动 疾病和神经退行性疾病，如阿尔茨海默氏症和帕金森氏症。我们的特别强调 该计划是为受训人员在“从工作台到床边”的框架内进行研究项目，确保 即使是我们的基础科学实习生也将直接接触到翻译或临床衰老研究。 培训的广度将通过要求所有受训人员参加一个全面的 3学期的老年神经科学研究生培训课程，以及每月一期的《老年神经科学》杂志 俱乐部和每月一次的负责任的研究班行为，并参加OHSU的科学外展工作。

PROJECT SUMMARY Population projections made by the US Census Bureau indicate that ~20% of the population will be >65 years old by 2030, and if correct, this demographic change will have a major impact on the economy and health of our nation. However, the mechanisms underlying normal and pathological human aging are still poorly understood, especially those associated with the nervous system, and safe and effective therapies have yet to be developed. Therefore, the primary aim of this T32 program is to provide students with basic, translational, and clinical research training in the Neuroscience of Aging and Neurodegeneration. Based on the experience of our 20-member faculty, who have previous trained 60 pre-doctoral students and 120 postdoctoral fellows, we expected that a total of 12 PhD or PhD/MD students and 8 postdoctoral fellows will be trained during the proposed 5-year funding period. Our program is thus expected to make a significant contribution to a national effort ensuring that there will be a sufficient number of trained researchers available in the ensuing decades, with expertise in normal and pathological human aging. Importantly, our program does not duplicate any other training program at OHSU, and it is the only mechanism by which students can obtain comprehensive research training in the Neuroscience of Aging and Neurodegeneration in the Pacific Northwest. The T32 training faculty bring ~$20,000,000 in direct research funds to the Oregon Health and Science University (OHSU) each year, in support of basic, translational, and clinical aging/neurodegeneration research. Furthermore, the faculty have primary appointments within the Schools of Medicine and Engineering, the Layton Aging & Alzheimer's Disease Center, the Oregon Institute of Occupational Health Sciences (OIOHS), the Vollum Institute, the Advanced Imaging Research Center (AIRC), the Jungers Center for Neuroscience Research, and the Oregon National Primate Research Center (ONPRC). Thus, our program offers training using a broad spectrum of animal models, including invertebrates, rodents, and nonhuman primates, as well as humans. It also provides extensive Research Core support and access to a wide range of cutting-edge resources and methodologies, including advanced in vivo brain imaging at one end of the spectrum and RNA- seq gene expression profiling at the other. Currently, the program's main aging-related research focus areas include: perturbed circadian rhythms, neuroendocrine-associated disorders, cognitive decline, movement disorders, and neurodegenerative diseases such as Alzheimer's and Parkinson's. A special emphasis of our program is for the trainees to conduct their research projects within a “bench-to-bedside” framework, ensuring that even our basic science trainees will obtain first-hand exposure to translational or clinical aging research. The breadth of the training will be further enhanced by requiring all of our trainees to attend a comprehensive 3-term Neuroscience of Aging graduate training course, as well as a monthly Neuroscience of Aging journal club and a monthly Responsible Conduct in Research class, and participate in OHSU science outreach efforts.