Neuroscience of Aging, Neurodegeneration and Alzheimer’s Disease

衰老、神经退行性疾病和阿尔茨海默病的神经科学

• 批准号: 10407666
• 负责人: HENRYK F URBANSKI
• 金额: $ 45.88万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407666
• 关键词: Aging; Alzheimer' s Disease; Nerve Degeneration; Neurosciences

PROJECT SUMMARY Population projections made by the US Census Bureau indicate that ~20% of the population will be >65 years old by 2030, and if correct, this demographic change will have a major impact on the economy and health of our nation. However, the mechanisms underlying normal and pathological human aging are still poorly understood, especially those associated with the nervous system, and safe and effective therapies have yet to be developed. Therefore, the primary aim of this T32 program is to provide students with basic, translational, and clinical research training in the Neuroscience of Aging and Neurodegeneration. Based on the experience of our 20-member faculty, who have previous trained 60 pre-doctoral students and 120 postdoctoral fellows, we expected that a total of 12 PhD or PhD/MD students and 8 postdoctoral fellows will be trained during the proposed 5-year funding period. Our program is thus expected to make a significant contribution to a national effort ensuring that there will be a sufficient number of trained researchers available in the ensuing decades, with expertise in normal and pathological human aging. Importantly, our program does not duplicate any other training program at OHSU, and it is the only mechanism by which students can obtain comprehensive research training in the Neuroscience of Aging and Neurodegeneration in the Pacific Northwest. The T32 training faculty bring ~$20,000,000 in direct research funds to the Oregon Health and Science University (OHSU) each year, in support of basic, translational, and clinical aging/neurodegeneration research. Furthermore, the faculty have primary appointments within the Schools of Medicine and Engineering, the Layton Aging & Alzheimer's Disease Center, the Oregon Institute of Occupational Health Sciences (OIOHS), the Vollum Institute, the Advanced Imaging Research Center (AIRC), the Jungers Center for Neuroscience Research, and the Oregon National Primate Research Center (ONPRC). Thus, our program offers training using a broad spectrum of animal models, including invertebrates, rodents, and nonhuman primates, as well as humans. It also provides extensive Research Core support and access to a wide range of cutting-edge resources and methodologies, including advanced in vivo brain imaging at one end of the spectrum and RNA- seq gene expression profiling at the other. Currently, the program's main aging-related research focus areas include: perturbed circadian rhythms, neuroendocrine-associated disorders, cognitive decline, movement disorders, and neurodegenerative diseases such as Alzheimer's and Parkinson's. A special emphasis of our program is for the trainees to conduct their research projects within a “bench-to-bedside” framework, ensuring that even our basic science trainees will obtain first-hand exposure to translational or clinical aging research. The breadth of the training will be further enhanced by requiring all of our trainees to attend a comprehensive 3-term Neuroscience of Aging graduate training course, as well as a monthly Neuroscience of Aging journal club and a monthly Responsible Conduct in Research class, and participate in OHSU science outreach efforts.

项目摘要 美国人口普查局制定的人口项目表明，约有20％的人口将> 65年 到2030年，旧的，如果正确的话，这种人口变化将对经济和健康产生重大影响 我们的国家。但是，人类衰老的基础机制仍然很差 了解齿，尤其是与神经系统相关的齿，以及安全有效的疗法尚未 被开发。因此，该T32计划的主要目的是为学生提供基本的，翻译的， 以及衰老和神经退行性神经科学的临床研究培训。基于经验 我们有20名成员的教职员工，他们以前曾接受过60名博士后学生和120名博士后研究员的培训， 我们希望总共有12名博士学位或博士/MD学生和8名博士后研究员在此期间接受培训 拟议的5年资金期。因此，我们的计划有望为国家做出重大贡献 努力确保将在随后的几十年中提供足够数量的训练有素的研究人员 具有正常和病理人类衰老方面的专业知识。重要的是，我们的计划不会复制任何其他 OHSU的培训计划，这是学生可以获得全面研究的唯一机制 西北太平洋的衰老和神经变性的神经科学培训。 T32培训教师将约20,000,000美元的直接研究资金带给俄勒冈州健康与科学 每年大学（OHSU），以支持基本，转化和临床老化/神经变性研究。 此外，教师在医学和工程学校内有主要任命 莱顿老化与阿尔茨海默氏病中心，俄勒冈州职业健康科学研究所（OIOHS）， Jungers神经科学中心高级成像研究中心（AIRC）Vollum Institute 研究和俄勒冈州国家灵长类动物研究中心（ONPRC）。那，我们的计划提供培训 使用广泛的动物模型，包括无脊椎动物，啮齿动物和非人类隐私以及 人类。它还提供了广泛的研究核心支持，并获得了广泛的尖端 资源和方法，包括频谱一端和RNA-的高级体内脑成像 Seq基因表达分析在另一个。目前，该计划的主要与衰老有关的研究重点领域 包括：受干扰的昼夜节律，神经内分泌相关疾病，认知能力下降，运动 疾病和神经退行性疾病，例如阿尔茨海默氏症和帕金森氏症。我们的特别强调 计划是为了让学员在“基准对床”框架内进行研究项目，以确保 即使是我们的基础科学培训，也将获得翻译或临床衰老研究的第一手接触。 通过要求我们所有的学员参加全面的培训，将进一步增强培训的广度 老龄化研究生培训课程的三个神经科学以及每月衰老期刊的神经科学 俱乐部和每月负责任的研究课程，并参加OHSU科学外展工作。