Neuroscience of Aging, Neurodegeneration and Alzheimer’s Disease

衰老、神经退行性疾病和阿尔茨海默病的神经科学

• 批准号: 10407666
• 负责人: HENRYK F URBANSKI
• 金额: $ 45.88万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407666
• 关键词: Aging; Alzheimer' s Disease; Nerve Degeneration; Neurosciences

PROJECT SUMMARY Population projections made by the US Census Bureau indicate that ~20% of the population will be >65 years old by 2030, and if correct, this demographic change will have a major impact on the economy and health of our nation. However, the mechanisms underlying normal and pathological human aging are still poorly understood, especially those associated with the nervous system, and safe and effective therapies have yet to be developed. Therefore, the primary aim of this T32 program is to provide students with basic, translational, and clinical research training in the Neuroscience of Aging and Neurodegeneration. Based on the experience of our 20-member faculty, who have previous trained 60 pre-doctoral students and 120 postdoctoral fellows, we expected that a total of 12 PhD or PhD/MD students and 8 postdoctoral fellows will be trained during the proposed 5-year funding period. Our program is thus expected to make a significant contribution to a national effort ensuring that there will be a sufficient number of trained researchers available in the ensuing decades, with expertise in normal and pathological human aging. Importantly, our program does not duplicate any other training program at OHSU, and it is the only mechanism by which students can obtain comprehensive research training in the Neuroscience of Aging and Neurodegeneration in the Pacific Northwest. The T32 training faculty bring ~$20,000,000 in direct research funds to the Oregon Health and Science University (OHSU) each year, in support of basic, translational, and clinical aging/neurodegeneration research. Furthermore, the faculty have primary appointments within the Schools of Medicine and Engineering, the Layton Aging & Alzheimer's Disease Center, the Oregon Institute of Occupational Health Sciences (OIOHS), the Vollum Institute, the Advanced Imaging Research Center (AIRC), the Jungers Center for Neuroscience Research, and the Oregon National Primate Research Center (ONPRC). Thus, our program offers training using a broad spectrum of animal models, including invertebrates, rodents, and nonhuman primates, as well as humans. It also provides extensive Research Core support and access to a wide range of cutting-edge resources and methodologies, including advanced in vivo brain imaging at one end of the spectrum and RNA- seq gene expression profiling at the other. Currently, the program's main aging-related research focus areas include: perturbed circadian rhythms, neuroendocrine-associated disorders, cognitive decline, movement disorders, and neurodegenerative diseases such as Alzheimer's and Parkinson's. A special emphasis of our program is for the trainees to conduct their research projects within a “bench-to-bedside” framework, ensuring that even our basic science trainees will obtain first-hand exposure to translational or clinical aging research. The breadth of the training will be further enhanced by requiring all of our trainees to attend a comprehensive 3-term Neuroscience of Aging graduate training course, as well as a monthly Neuroscience of Aging journal club and a monthly Responsible Conduct in Research class, and participate in OHSU science outreach efforts.

项目摘要 美国人口普查局的人口预测表明，约20%的人口将超过65岁。 到2030年，如果正确的话，这种人口结构的变化将对经济和健康产生重大影响。 我们的国家然而，人类正常衰老和病理衰老的机制仍然很差 人们已经了解，尤其是与神经系统相关的疾病，而且安全有效的治疗方法尚未确定 发展。因此，这个T32计划的主要目的是为学生提供基本的，翻译的， 以及衰老和神经变性神经科学的临床研究培训。经验的基础上 在我们的20名教师中，他们以前培养了60名博士前学生和120名博士后研究员， 我们预计，共有12名博士或博士/医学博士生和8名博士后研究员将在培训期间， 五年融资期。因此，我们的计划预计将作出重大贡献，一个国家 努力确保在今后几十年内有足够数量的训练有素的研究人员， 在正常和病理性人类衰老方面有专业知识。重要的是，我们的程序不会复制任何其他 OHSU的培训计划，这是学生可以获得全面研究的唯一机制 在太平洋西北部的衰老和神经变性的神经科学培训。 T32培训学院为俄勒冈州健康与科学学院带来了约2000万美元的直接研究资金。 大学（OHSU）每年，以支持基础，转化和临床衰老/神经变性研究。 此外，教师在医学和工程学院， 莱顿老龄化和阿尔茨海默病中心，俄勒冈州职业健康科学研究所（OIOHS）， Vollum研究所，高级成像研究中心（AIRC），荣格神经科学中心 研究和俄勒冈州国家灵长类动物研究中心（ONPRC）。因此，我们的计划提供培训 使用广泛的动物模型，包括无脊椎动物、啮齿动物和非人灵长类动物，以及 人类它还提供广泛的研究核心支持，并获得广泛的尖端 资源和方法，包括先进的体内脑成像在一端的频谱和RNA- 另一个是seq基因表达谱分析。目前，该计划的主要研究重点领域是与老龄化有关的 包括：昼夜节律紊乱、神经内分泌相关疾病、认知能力下降、运动 疾病和神经退行性疾病，如阿尔茨海默氏症和帕金森氏症。我们特别强调 该计划旨在让学员在“从实验室到床边”的框架内开展研究项目，确保 即使是我们的基础科学学员也将获得第一手的转化或临床衰老研究。 培训的范围将进一步扩大，要求所有学员参加一个全面的 3-长期的神经科学老化研究生培训课程，以及每月的神经科学老化杂志 俱乐部和每月一次的负责任的行为研究类，并参加OHSU科学外展工作。