CIRCADIAN CLOCK MECHANISMS IN THE BRAIN AND PERIPHERAL ORGANS

大脑和周围器官的昼夜节律机制

• 批准号: 8357866
• 负责人: HENRYK F URBANSKI
• 金额: $ 1.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357866
• 关键词: Affect; Aging; Body part; Brain; Brain region; Circadian Rhythms; Funding; Genes; Grant; Human; Learning; Macaca mulatta; Methodology; National Center for Research Resources; Organ; Peripheral; Photoperiod; Physiology; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Reverse Transcriptase Polymerase Chain Reaction; School Teachers; Science; Source; Training; United States National Institutes of Health; circadian pacemaker; cost; high school; meetings; sleep onset; suprachiasmatic nucleus; teacher

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Many aspects of human physiology, including onset of sleep, are thought to be controlled by a circadian clock located in the suprachiasmatic nucleus of the brain. However, there is now compelling evidence that other oscillator circuits may also be involved. This "Partners-in-Science" project gives a high-school teacher the opportunity to examine how different brain regions and different peripheral organs regulate circadian physiology in rhesus macaques. Specifically, he is learning how to analyze GeneChip microarrays and how to perform RT-PCR. These methodologies will enable him to examine how the expression of clock-related genes in different parts of the body is affected by aging and changes in photoperiod. The teacher completed the first year of his 2-year training and recently presented some of his results at the annual national Partners-in-Science meeting.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 人类生理的许多方面，包括睡眠的开始，都被认为是由位于大脑视交叉上核的生物钟控制的。然而，现在有令人信服的证据表明，其他振荡器电路也可能参与其中。这个“科学伙伴”项目让一位高中教师有机会研究不同的大脑区域和不同的外周器官是如何调节恒河猴的昼夜生理的。具体地说，他正在学习如何分析基因芯片微阵列以及如何进行RT-PCR。这些方法将使他能够研究与时钟相关的基因在身体不同部位的表达如何受到衰老和光周期变化的影响。这位教师完成了他为期两年的培训的第一年，最近在年度全国科学合作伙伴会议上展示了他的一些成果。