Development and evaluation of a next-generation safety device for haemodialysis and safety-critical vascular lines

在美国和欧盟/英国，每年有130万终末期肾功能衰竭(ESRF)患者接受2.02亿次血液透析。其中，每年有惊人的1000名血液透析患者死于致命的针头移位--这是一种当强制将针头从瘘道部位拔出时发生的并发症。对灾难性针头移位并发症的安全担忧仍然是患者更多地接受家庭和/或夜间透析的头号障碍-这些新兴模式改善了患者的体验和结果；每人每年节省高达15,000 GB的提供者成本。这一工业研究智能项目将实现透析线安全的技术飞跃，具有广泛的相邻应用潜力。在临床医生和患者的参与下，一种集成的联网医疗设备将被开发成高保真的原型，该设备能够确保和感知透析线上的移位力。来自Innovate UK的支持将确保该项目的影响，为医疗保健、英国中小企业、制造业和供应链创造健康和经济价值。

Each year, across the US and EU/UK, 1.3M patients with end-stage renal failure ("ESRF") undergo 202M episodes of haemodialysis. Among them, a staggering 1000 haemodialysis patients die each year from fatal needle dislodgement -- a complication that occurs when forces dislodge the needle from the fistula site.Safety concerns over catastrophic needle dislodgement complications remain the number one barrier to greater patient uptake of home and/or nocturnal dialysis - these emerging modalities improve patient experience and outcomes; and save up to £15,000 per person per year in provider costs.This industrial research SMART project will achieve a technological leap forward in dialysis line safety with potential widespread adjacent application. An integrated connected medical device with the capability to secure and sense dislodgement force on dialysis lines will be developed to a high-fidelity prototype with involvement of clinicians and patients.Support from Innovate UK will secure this project's impact, generating health and economic value for healthcare, UK SMEs, manufacturing and supply chains.