Impact of the COVID-19 Pandemic on Alcohol Use and PTSD Symptoms in a Sample of African American Heavy Drinkers

项目概要/摘要 当前的全球流行病提出了关于大量饮酒和酒精使用方式的至关重要的问题 疾病（AUD）可能会增加COVID-19疾病的风险，并参与降低风险的策略，以及如何 与流行病有关的不确定性和压力以及遏制流行病的措施可能会影响饮酒和相关结果。 我们目前的NIAAA资助的研究（抗谷氨酰胺能药物治疗共病PTSD & AUD; 5 R 01 AA 024760）正在测试普瑞巴林在减轻AUD症状和创伤后应激方面的疗效 在大多数低社会经济地位（SES）的非洲裔美国男性和女性的样本中， 经历了一系列的人生创伤在试验过程中，我们评估了140名酗酒者， 通过各种酒精使用、创伤经历、创伤后应激障碍和情绪症状、其他物质使用和 一般功能（即，照顾自己，与他人沟通和互动，照顾工作， 家庭责任）。对这个高度多样化的样本的进一步研究有可能揭示 大流行病对高危社区成员的后果，以及与大流行病有关的 压力，不确定性和社会孤立可能会影响酒精使用和相关结果。关于特别通知 兴趣：关于冠状病毒疾病的行政补充和竞争性修订补充的可用性 在NIAAA的使命（NOT-AA-20-011）中，我们建议利用现有的研究 队列研究对COVID-19大流行具有重要意义的紧迫研究问题， 患有酒精使用和精神健康障碍共病的参与者人群。首先，我们将收集描述性数据 关于参与者的COVID-19疾病经历和参与降低风险的实践。这将包括经验 通过COVID-19的检测，治疗和住院治疗，以及参与降低风险的实践，如社会 保持距离戴着面具其次，我们将探讨酒精使用，PTSD症状，其他物质 使用、情绪症状、社会支持和一般功能与参与COVID-19风险降低相关 实践第三，我们将比较酒精使用，创伤后应激障碍症状，其他物质使用，情绪症状，以及一般 在大流行爆发之前（2020年2月1日之前）和之后评估功能，以检查 大流行影响了这些领域。包括功能结果的测量提供了探索 大流行影响了参与者继续发挥有意义的家庭和社会作用的能力。

Project Summary/Abstract The current global pandemic raises critically important questions about the ways that heavy drinking and alcohol use disorder (AUD) may increase risk for COVID-19 illness and engaging in risk reduction strategies, as well as how uncertainty and stress related to the pandemic and measures to contain it may impact drinking and related outcomes. Our current NIAAA-funded study (Pharmacogenetic Treatment with Anti-Glutaminergic Agents for Comorbid PTSD & AUD; 5R01AA024760) is testing the efficacy of pregabalin in reducing symptoms of AUD and posttraumatic stress disorder (PTSD) in a sample of mostly low socioeconomic status (SES) African American men and women who have experienced an array of lifetime traumatic events. Over the course of the trial, we have assessed 140 heavy drinkers with a variety of measures of alcohol use, trauma experiences, PTSD and mood symptoms, other substance use, and general functioning (i.e., taking care of oneself, communicating and interacting with others, taking care of work and domestic responsibilities). Further examination of this highly diverse sample has the potential to shed light on the consequences of the pandemic on high-risk community members and the ways that pandemic-related experiences of stress, uncertainty, and social isolation may impact alcohol use and related outcomes. In response to Notice of Special Interest: Availability of Administrative Supplements and Competitive Revision Supplements on Coronavirus Disease 2019 (COVID-19) within the Mission of NIAAA (NOT-AA-20-011), we propose to capitalize on this existing research cohort to investigate urgent research questions of significance to the COVID-19 pandemic among an underserved population of participants with comorbid alcohol use and mental health disorders. First, we will collect descriptive data on participants’ experiences of COVID-19 illness and engaging in risk reduction practices. This will include experiences with testing, treatment, and hospitalization for COVID-19, as well as engaging in risk reduction practices such as social distancing and wearing masks. Second, we will explore the ways that alcohol use, PTSD symptoms, other substance use, mood symptoms, social support, and general functioning are related to engaging in COVID-19 risk reduction practices. Third, we will compare alcohol use, PTSD symptoms, other substance use, mood symptoms, and general functioning assessed before (prior to February 1, 2020) and after the onset of the pandemic to examine how the pandemic affected these domains. Including measures of functional outcomes offers the opportunity to explore how the pandemic has impacted participants’ ability to continue to perform meaningful family and societal roles.