Impact of the COVID-19 Pandemic on Alcohol Use and PTSD Symptoms in a Sample of African American Heavy Drinkers

COVID-19 大流行对非裔美国人酗酒者样本中酒精使用和创伤后应激障碍 (PTSD) 症状的影响

• 批准号: 10176659
• 负责人: MELANIE E. BENNETT
• 金额: $ 15.27万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176659
• 关键词: Administrative Supplement; Affect; African American; Alcohol consumption; Alcohol or Other Drugs use; Alcoholic beverage heavy drinker; COVID-19; COVID-19 pandemic; Caring; Centers for Disease Control and Prevention (U.S.); Communities; Community Surveys; Data; Drug usage; Family; Funding; Heavy Drinking; Hospitalization; Light; Masks; Measures; Mental disorders; Mission; National Institute on Alcohol Abuse and Alcoholism; Outcome; Participant; Pharmacogenetics; Post-Traumatic Stress Disorders; Reporting; Research; Risk; Risk Reduction; Role; Sampling; Social Distance; Social isolation; Social support; Stress; Symptoms; Testing; Trauma; Uncertainty; Underserved Population; Woman; Work; alcohol comorbidity; alcohol use disorder; cohort; comorbidity; coping; drinking; efficacy testing; experience; functional outcomes; high risk; interest; low socioeconomic status; member; men; mood symptom; pandemic disease; pregabalin; reduce symptoms; response; stressor; traumatic event

Project Summary/Abstract The current global pandemic raises critically important questions about the ways that heavy drinking and alcohol use disorder (AUD) may increase risk for COVID-19 illness and engaging in risk reduction strategies, as well as how uncertainty and stress related to the pandemic and measures to contain it may impact drinking and related outcomes. Our current NIAAA-funded study (Pharmacogenetic Treatment with Anti-Glutaminergic Agents for Comorbid PTSD & AUD; 5R01AA024760) is testing the efficacy of pregabalin in reducing symptoms of AUD and posttraumatic stress disorder (PTSD) in a sample of mostly low socioeconomic status (SES) African American men and women who have experienced an array of lifetime traumatic events. Over the course of the trial, we have assessed 140 heavy drinkers with a variety of measures of alcohol use, trauma experiences, PTSD and mood symptoms, other substance use, and general functioning (i.e., taking care of oneself, communicating and interacting with others, taking care of work and domestic responsibilities). Further examination of this highly diverse sample has the potential to shed light on the consequences of the pandemic on high-risk community members and the ways that pandemic-related experiences of stress, uncertainty, and social isolation may impact alcohol use and related outcomes. In response to Notice of Special Interest: Availability of Administrative Supplements and Competitive Revision Supplements on Coronavirus Disease 2019 (COVID-19) within the Mission of NIAAA (NOT-AA-20-011), we propose to capitalize on this existing research cohort to investigate urgent research questions of significance to the COVID-19 pandemic among an underserved population of participants with comorbid alcohol use and mental health disorders. First, we will collect descriptive data on participants’ experiences of COVID-19 illness and engaging in risk reduction practices. This will include experiences with testing, treatment, and hospitalization for COVID-19, as well as engaging in risk reduction practices such as social distancing and wearing masks. Second, we will explore the ways that alcohol use, PTSD symptoms, other substance use, mood symptoms, social support, and general functioning are related to engaging in COVID-19 risk reduction practices. Third, we will compare alcohol use, PTSD symptoms, other substance use, mood symptoms, and general functioning assessed before (prior to February 1, 2020) and after the onset of the pandemic to examine how the pandemic affected these domains. Including measures of functional outcomes offers the opportunity to explore how the pandemic has impacted participants’ ability to continue to perform meaningful family and societal roles.

项目摘要/摘要 目前的全球大流行提出了至关重要的问题，即大量饮酒和饮酒 障碍(澳元)可能会增加新冠肺炎疾病的风险，并参与降低风险的策略，以及如何 与大流行有关的不确定性和压力以及遏制它的措施可能会影响饮酒和相关结果。 我们目前由NIAAA资助的研究(用抗谷氨酰胺能药物对并发的PTSD和 AUD；5R01AA024760)正在测试普瑞巴林在减轻AUD和创伤后应激症状方面的疗效 精神障碍(PTSD)的样本大多是低社会经济地位(SES)的非裔美国人男性和女性 经历了一系列的终生创伤事件。在试验过程中，我们评估了140名酗酒者 有酒精使用，创伤经历，创伤后应激障碍和情绪症状，其他物质使用的各种衡量标准，以及 一般功能(即照顾自己、与他人沟通和互动、照顾工作和 国内责任)。对这种高度多样化的样本的进一步检查有可能揭示 大流行对高危社区成员的影响以及与大流行相关的经验 压力、不确定性和社会孤立可能会影响饮酒和相关结果。回应特别通告 兴趣：提供针对冠状病毒疾病的行政补充剂和竞争性修订补充剂 2019年(新冠肺炎)在美国国家航空航天局(NOT-AA-20-011)的任务范围内，我们建议利用这一现有研究 在服务不足的人群中调查对新冠肺炎大流行具有重要意义的紧迫研究问题 同时患有酒精使用和精神健康障碍的参与者群体。首先，我们将收集描述性数据 关于参与者患新冠肺炎和从事降低风险实践的经验。这将包括体验 为新冠肺炎提供检测、治疗和住院服务，并从事降低风险的实践，如社交 保持距离并戴上口罩。其次，我们将探索酒精使用、创伤后应激障碍症状、其他物质 使用、情绪症状、社会支持和一般功能与参与新冠肺炎风险降低有关 练习。第三，我们将比较酒精使用、创伤后应激障碍症状、其他药物使用、情绪症状和一般情况 在大流行爆发之前(2020年2月1日之前)和之后进行功能评估，以检查 大流行影响了这些领域。包括对功能结果的测量提供了机会来探索 大流行影响了参与者继续发挥有意义的家庭和社会作用的能力。