Genome Editing Test Section
Genome Editing Test Section
批准号:
10178137
负责人:
JONATHAN A GREEN
金额:
$104.45万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-06-01 至 2024-05-31
关键词:
AddressAffectAmino Acid SubstitutionAnimal ModelAntibodiesBladderChemicalsCochleaCollaborationsEnsureEpigenetic ProcessEvaluationFamily suidaeGene DeliveryGenesGenetic RecombinationGenomeGoalsIndividualInhalationInjectionsInnate Immune ResponseIntramuscularLipidsMessenger RNAMethodsModelingModificationNatureOutcomePathway interactionsPhysiologicalProceduresProcessProductionProteomeReactionReagentReporterReportingResearchResourcesRiskRoleRouteSafetyServicesSinusSiteSpinalSystemTechnologyTestingTherapeuticTimeTissuesToxic effectTranslationsUnited States National Institutes of HealthValidationViralViral VectorVirusbasecomparativedesignefficacy testingexperiencegenome editinggenome integrityhazardin vivo evaluationintraperitonealmembernanoparticleneoantigensnew technologynovelnucleaseparticleprogramsresponsesafety testingsomatic cell gene editingsubcutaneoussuccesstooltranscriptometransgene expressionvectorviral gene delivery
中文摘要
项目摘要-基因组编辑测试部分
基因组编辑测试部分的作用将是验证由基因组编辑测试部分创建的独特报告模型。
动物模型生产部门,并测试其他部门提供的新型给药方法和试剂
体细胞基因组编辑联盟(Somatic Cell Genome Editing,SCGE)此外,基因组编辑
测试部门将负责制定详细的标准操作规程(SOP),
测试新基因组编辑技术的全面报告。必须有一个好的-
建立了验证和测试新基因组编辑技术的管道,以促进适当的
在确保技术安全性的同时完善工具。基因组编辑测试部分将
简化测试过程,同时保持全面和严格的比较分析,
新的基因组编辑工具和递送系统。我们的团队非常适合提供这种测试,因为我们
具有养猪经验的个体的独特组成,猪生物医学模型,
运营成功的实验室,定期测试尖端的基因组编辑技术,并与
国家猪资源与研究中心(NSRRC)。基因组编辑测试
部分将对整个MU基因组编辑猪检测中心产生重大影响
技术准确评估新技术的能力,并进一步促进利用基因组的能力
在治疗环境中进行编辑。
英文摘要
Project Summary -Genome Editing Testing Section
The role of the Genome Editing Testing Section will be to validate unique reporter models created by the
Animal Model Production Section and to test novel delivery methods and reagents provided by other
members of the Somatic Cell Genome Editing (SCGE) Consortium. Additionally, the Genome Editing
Testing Section will be responsible for creating detailed standard operating procedures (SOPs) and
comprehensive reports for testing new genome editing technologies. It is essential to have a well-
established pipeline for the validation and testing of new genome editing technology to facilitate proper
refinement of the tools while ensuring the safety of the technology. The Genome Editing Testing Section will
streamline the testing process while maintaining a comprehensive and rigorous comparative analysis of
new genome editing tools and delivery systems. Our group is ideally suited to provide this testing due to our
unique composition of individuals that are experienced with pig production, swine biomedical models,
operate successful labs that routinely test cutting-edge genome editing technology, and are associated with
world-renowned National Swine Resource and Research Center (NSRRC). The Genome Editing Testing
Section will have a significant impact on the overall MU Swine Testing Center for Genome Editing
Technologies’ ability to accurately assess new technologies and further facilitate the ability to use genome
editing in therapeutic circumstances.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Swine Somatic Cell Gene Editing Testing Center
-
批准号:10773796
-
项目类别:
-
资助金额:$132.98万
-
财政年份:2023
-
负责人:JONATHAN A GREEN
-
依托单位:
Suramin for Recluse Spider Bites
-
批准号:10258847
-
项目类别:
-
资助金额:$18.89万
-
财政年份:2021
-
负责人:JONATHAN A GREEN
-
依托单位:
Genome Editing Test Section
-
批准号:10650354
-
项目类别:
-
资助金额:$104.45万
-
财政年份:2019
-
负责人:JONATHAN A GREEN
-
依托单位:
Genome Editing Test Section
-
批准号:10414789
-
项目类别:
-
资助金额:$118.73万
-
财政年份:2019
-
负责人:JONATHAN A GREEN
-
依托单位:
Modification of SCNT donor cell metabolism to mimic blastomere metabolism
-
批准号:8741267
-
项目类别:
-
资助金额:$25.32万
-
财政年份:2014
-
负责人:JONATHAN A GREEN
-
依托单位:
Genome Editing Test Section
-
批准号:9769995
-
项目类别:
-
资助金额:$59.86万
-
财政年份:--
-
负责人:JONATHAN A GREEN
-
依托单位:
海外基金