Swine Somatic Cell Gene Editing Testing Center

猪体细胞基因编辑检测中心

• 批准号: 10773796
• 负责人: JONATHAN A GREEN
• 金额: $ 132.98万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-12 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10773796
• 关键词: Address; Animal Experiments; Animal Model; Animal Testing; Animals; Basic Science; Breeding; Clinic; Collaborations; Communication; Communities; Cryopreservation; Data Storage and Retrieval; Development; Discipline; Effectiveness; Emerging Technologies; Ensure; Evaluation; Family suidae; Fee-for-Service Plans; Foundations; Funding; Future; Genes; Genetic; Genome; Goals; Housing; Human; Impact evaluation; Income; Individual; Inflammation; Infrastructure; Logistics; Maintenance; Methods; Mission; Modeling; Physiological; Procedures; Process; Production; Reagent; Reporter; Reporting; Research; Resources; Role; Safety; Services; Standardization; System; Technology; Testing; Therapeutic; Therapeutic Intervention; United States National Institutes of Health; biosafety level 2 facility; clinically relevant; cohort; comparative; efficacy evaluation; experience; genetic resource; genome editing; human disease; human model; immunogenicity; in vivo; new therapeutic target; novel; novel therapeutic intervention; porcine model; preservation; programs; reduce symptoms; somatic cell gene editing; testing services; therapy duration; tool; translational therapeutics

PROJECT SUMMARY: OVERALL The overall purpose of this project is to provide services to the somatic cell genome editing community. Those serviced include to 1) produce, import, cryopreserve, and supply swine biomedical models for the somatic cell genome editing research community, 2) evaluate the safety and efficacy of somatic cell genome editing strategies, and 3) determine the therapeutic value, window of opportunity, and duration of therapies. It is anticipated that these services will advance basic research through testing of novel reagents as well as facilitating translation of therapeutic interventions into the clinic. The role of the Genome Editing Coordination Section will be to manage communication and logistics associated with Swine SCGE Center. These responsibilities include reporting to NIH and regulatory agencies when appropriate as well as communicating with Center Users, the Program Steering Committee, and various collaborators. The role of the Genome Editing Resource Section will be to produce, import, cryopreserve, validate, and supply unique swine models. The Resource Section will also maintain breeding colonies and produce cohorts of experimental animals, and it will be responsible for assembly and maintenance of BSL2 facilities for use by the Testing Section. The role of the Genome Editing Testing Section will be to provide novel delivery methods and reagents for the Somatic Cell Genome Editing community. The Genome Editing Testing Section will streamline the testing process while maintaining a comprehensive and rigorous comparative analysis of new genome editing tools and delivery systems. Our group is ideally suited to provide this testing due to our unique composition of individuals that are experienced with pig production, swine biomedical models, operate successful labs that routinely test cutting-edge genome editing technology, and are associated with world-renowned National Swine Resource and Research Center (NSRRC) and the sunsetting Swine Somatic Cell Genome Editing Consortium Large Animal Testing Center.

项目概要：总体 该项目的总体目的是为体细胞基因组编辑社区提供服务。那些 服务内容包括：1）生产、进口、冷冻保存和供应猪体细胞生物医学模型 基因组编辑研究社区，2）评估体细胞基因组编辑的安全性和有效性 策略，以及3）确定治疗价值，机会窗口和治疗持续时间。是 预计这些服务将通过测试新试剂以及 促进将治疗干预转化为临床。基因组编辑协调的作用 部门将负责管理与猪SCGE中心相关的沟通和物流。这些 职责包括在适当的时候向NIH和监管机构报告， 与中心用户、计划指导委员会和各种合作者一起。基因组的作用 编辑资源部分将用于生产、进口、冷冻保存、验证和提供独特的猪模型。 资源科还将维持繁殖群，并生产实验动物群， 将负责组装和维护BSL 2设施，供测试部门使用。的作用 基因组编辑测试部分将为体细胞基因组提供新的递送方法和试剂。 细胞基因组编辑社区。基因组编辑测试科将简化测试流程 同时对新的基因组编辑工具进行全面和严格的比较分析， 运载系统。由于我们独特的个人组成，我们的团队非常适合提供这种测试 有养猪经验的人，猪的生物医学模型，操作成功的实验室， 尖端的基因组编辑技术，并与世界著名的国家猪资源 和研究中心（NSRRC）和日落猪体细胞基因组编辑联盟大型 动物试验中心