Swine Somatic Cell Gene Editing Testing Center

项目总结：总体 该项目的总体目的是为体细胞基因组编辑社区提供服务。那些 提供的服务包括：1)生产、进口、冷冻保存和供应猪的体细胞生物医学模型 基因组编辑研究界，2)评价体细胞基因组编辑的安全性和有效性 策略，以及3)确定治疗价值、机会窗口和治疗持续时间。它是 预计这些服务将通过测试新试剂和 促进将治疗干预措施转化为临床干预措施。基因组编辑协调的作用 该部门将负责管理与猪SCGE中心相关的沟通和物流。这些 职责包括在适当的时候向国家卫生研究院和监管机构报告，以及沟通 与中心用户、计划指导委员会和各种合作者合作。基因组的作用 编辑资源科将生产，进口，冷冻保存，验证，并提供独特的猪模型。 资源科还将维持繁殖群体并产生实验动物队列，它 将负责组装和维护BSL2设施，供测试科使用。的作用 基因组编辑测试科将为体细胞提供新的递送方法和试剂 细胞基因组编辑社区。基因组编辑测试科将简化测试过程 同时保持对新的基因组编辑工具和 传输系统。由于我们个人的独特构成，我们的团队非常适合提供这项测试 在生猪生产、猪生物医学模型方面经验丰富的人，运营着成功的实验室，这些实验室定期进行测试 尖端基因组编辑技术，并与世界著名的国家猪资源 和研究中心(NSRRC)和夕阳猪体细胞基因组编辑大联盟 动物检测中心。

PROJECT SUMMARY: OVERALL The overall purpose of this project is to provide services to the somatic cell genome editing community. Those serviced include to 1) produce, import, cryopreserve, and supply swine biomedical models for the somatic cell genome editing research community, 2) evaluate the safety and efficacy of somatic cell genome editing strategies, and 3) determine the therapeutic value, window of opportunity, and duration of therapies. It is anticipated that these services will advance basic research through testing of novel reagents as well as facilitating translation of therapeutic interventions into the clinic. The role of the Genome Editing Coordination Section will be to manage communication and logistics associated with Swine SCGE Center. These responsibilities include reporting to NIH and regulatory agencies when appropriate as well as communicating with Center Users, the Program Steering Committee, and various collaborators. The role of the Genome Editing Resource Section will be to produce, import, cryopreserve, validate, and supply unique swine models. The Resource Section will also maintain breeding colonies and produce cohorts of experimental animals, and it will be responsible for assembly and maintenance of BSL2 facilities for use by the Testing Section. The role of the Genome Editing Testing Section will be to provide novel delivery methods and reagents for the Somatic Cell Genome Editing community. The Genome Editing Testing Section will streamline the testing process while maintaining a comprehensive and rigorous comparative analysis of new genome editing tools and delivery systems. Our group is ideally suited to provide this testing due to our unique composition of individuals that are experienced with pig production, swine biomedical models, operate successful labs that routinely test cutting-edge genome editing technology, and are associated with world-renowned National Swine Resource and Research Center (NSRRC) and the sunsetting Swine Somatic Cell Genome Editing Consortium Large Animal Testing Center.