Administrative Core NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome
Administrative Core NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome
批准号:
10177979
负责人:
ROBERT W. WILLIAMS
金额:
$9.44万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-08-01 至 2024-05-31
关键词:
Animal ModelArchivesBiologyBiometryChromosome MappingCodeCollaborationsCommunitiesComplexConflict (Psychology)ConsultDNADataData SetDevelopmentDiagnosisDiseaseDocumentationDrug AddictionDrug ModelingsDrug abuseEducation and OutreachEducational workshopEnvironmentEnvironmental Risk FactorEpigenetic ProcessFamilyGeneticGenomeGenomicsGenotype-Tissue Expression ProjectGoalsGrantHybridsInformaticsInstitutionInternetLeadershipLibrariesMachine LearningMass Spectrum AnalysisMathematicsMetadataMetagenomicsMethodsModelingMolecularMultiomic DataNational Institute of Drug AbuseNational Institute on Alcohol Abuse and AlcoholismParticipantPharmaceutical PreparationsPharmacotherapyPostdoctoral FellowPreventionProteomeProtocols documentationPublicationsRNARat Genome DatabaseRattusRecordsRelapseReportingReproducibilityResearchResearch PersonnelResearch SupportResourcesRiskRisk FactorsRodentRunningScienceServicesStressStudentsSumSystemTestingTrainingTraining ProgramsTreatment outcomeUnited States National Institutes of HealthVertebral columnVisitWestern BlottingWorkaddictionbehavior influencebehavioral studybrain cellcohortdata sharingdrug relapseepigenomeexpectationexperimental studygenetic variantimprovedinnovationmachine learning methodmeetingsmembermetabolomeneuronal circuitryonline resourceoutreach programpatch sequencingphenomeprecision medicinepreventprogramsranpirnasesexsoftware systemstranscriptometranscriptome sequencingtranscriptomicsvectorwebinar
中文摘要
成瘾是一种高度复杂的疾病,其危险因素包括基因变异和基因差异
英文摘要
Addiction is a highly complex disease with risk factors that include genetic variants and differences in
development, sex, and environment. The long term potential of precision medicine to improve drug treatment
and prevention depends on gaining a much better understanding how genetics, drugs, brain cells, and
neuronal circuitry interact to influence behavior. There are serious technical barriers that prevent researchers
and clinicians from incorporating more powerful computational and predictive methods in addiction research.
The purpose of the NIDA P30 Core Center of Excellence in Omics, Systems Genetics, and the Addictome
is to empower and train researchers supported by NIH, NIDA, NIAAA, and other federal and state institutions
to use more quantitative and testable ways to analyze genetic, epigenetic, and the environmental factors that
influence drug abuse risk and treatment. The Administrative Core manages relations among research cores,
groups of users, trainees, and pilot program participants. The Transcriptome Informatics and Mechanisms
research core assembles and analyzes hundreds of large genome (DNA) and transcriptome (RNA) datasets
for experimental rodent (rat) models of addiction. The Systems Analytics and Modeling research core, is using
innovative systems genetics methods (gene mapping) to understand the linkage between DNA differences,
environmental risks such as stress, and the differential risk of drug abuse and relapse. The Pilot core is
catalyzing new collaborations among young investigator in the field of addiction research. In sum the Center is
a national resource for more reproducible research in addiction. We are centralizing, archiving, distributing,
analyzing and integrating high quality data, metadata, using open software systems in collaboration with many
other teams of researchers. Our goal is to help build toward an NIDA Addictome Portal that will include all
genomic research relevant to addiction research.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Pilot Research Project Core NIDA "COE" Transcriptomics, Systems Genetics and the Addictome
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批准号:10177982
-
项目类别:
-
资助金额:$2.78万
-
财政年份:2017
-
负责人:ROBERT W. WILLIAMS
-
依托单位:
Translational Systems Genetics of Mitochondria, Metabolism, and Aging
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批准号:8716630
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项目类别:
-
资助金额:$50.58万
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财政年份:2013
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负责人:ROBERT W. WILLIAMS
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依托单位:
Translational Systems Genetics of Mitochondria, Metabolism, and Aging
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批准号:8576097
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项目类别:
-
资助金额:$52.8万
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财政年份:2013
-
负责人:ROBERT W. WILLIAMS
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依托单位:
Translational Systems Genetics of Mitochondria, Metabolism, and Aging
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批准号:8852521
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项目类别:
-
资助金额:$49.06万
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财政年份:2013
-
负责人:ROBERT W. WILLIAMS
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依托单位:
Systems Genetics of the HPA
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批准号:8102053
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项目类别:
-
资助金额:$22.06万
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财政年份:2008
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负责人:ROBERT W. WILLIAMS
-
依托单位:
Systems Genetics of the HPA
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批准号:7498204
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项目类别:
-
资助金额:$23.04万
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财政年份:2008
-
负责人:ROBERT W. WILLIAMS
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依托单位:
Systems Genetics of the HPA
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批准号:7661695
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项目类别:
-
资助金额:$23.19万
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财政年份:2008
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负责人:ROBERT W. WILLIAMS
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依托单位:
Systems Genetics of the HPA
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批准号:7883191
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项目类别:
-
资助金额:$22.95万
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财政年份:2008
-
负责人:ROBERT W. WILLIAMS
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依托单位:
INIA: Bioinformatics Core
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批准号:8601916
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项目类别:
-
资助金额:$19.04万
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财政年份:2007
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负责人:ROBERT W. WILLIAMS
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依托单位:
INIA: Bioinformatics Core
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批准号:8727145
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项目类别:
-
资助金额:$1.8万
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财政年份:2007
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负责人:ROBERT W. WILLIAMS
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依托单位:
INIA: Bioinformatics Core
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批准号:9000077
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项目类别:
-
资助金额:$19.63万
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财政年份:2007
-
负责人:ROBERT W. WILLIAMS
-
依托单位:
INIA: Bioinformatics Core
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批准号:8423712
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项目类别:
-
资助金额:$18.25万
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财政年份:2007
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负责人:ROBERT W. WILLIAMS
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依托单位:
INIA: Bioinformatics Core
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批准号:8231598
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项目类别:
-
资助金额:$19.63万
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财政年份:2007
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负责人:ROBERT W. WILLIAMS
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依托单位:
INIA:Complex Trait Analysis--Alcohol /Stress Interaction
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批准号:6694108
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项目类别:
-
资助金额:$32.85万
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财政年份:2002
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负责人:ROBERT W. WILLIAMS
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依托单位:
INIA:Complex Trait Analysis--Alcohol /Stress Interaction
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批准号:6999337
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项目类别:
-
资助金额:$45.55万
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财政年份:2002
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负责人:ROBERT W. WILLIAMS
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依托单位:
Systems Genetics of Alcohol Response and Stress Effects in CNS
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批准号:8231100
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项目类别:
-
资助金额:$23.23万
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财政年份:2002
-
负责人:ROBERT W. WILLIAMS
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依托单位:
INIA: Robust Systems Genetics of Alcohol and Stress Effects on CNS
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批准号:7568800
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项目类别:
-
资助金额:$33.59万
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财政年份:2002
-
负责人:ROBERT W. WILLIAMS
-
依托单位:
INIA:Complex Trait Analysis--Alcohol /Stress Interaction
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批准号:6927646
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项目类别:
-
资助金额:$4.8万
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财政年份:2002
-
负责人:ROBERT W. WILLIAMS
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依托单位:
Systems Genetics of Alcohol Response and Stress Effects in CNS
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批准号:8797087
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项目类别:
-
资助金额:$22.53万
-
财政年份:2002
-
负责人:ROBERT W. WILLIAMS
-
依托单位:
INIA:Complex Trait Analysis--Alcohol /Stress Interaction
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批准号:6840432
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项目类别:
-
资助金额:$38.63万
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财政年份:2002
-
负责人:ROBERT W. WILLIAMS
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依托单位:
海外基金