INIA: Bioinformatics Core

描述（由申请人提供）：INIA计划的一个关键目标是改变对酗酒原因，预防和治疗的研究。在广泛的研究范围内整合数据集和分析方法是成功的关键。这个INIA UOI核心应用程序是建立在几个强大的INIA Web服务和数据资源的成功基础上的，包括GeneNetwork，WebGestalt和Ontological Discovery Environment（ODE）。然而，我们在这一更新中的目标是基因组学和神经科学快速变化的直接产物，特别是下一代测序。这一核心的一个主题是融合创新。在过去的五年里，网络服务在神经科学中的广泛应用--艾伦脑图谱、大卫、ODE、Galaxy、GeneNetwork、GeneWiki、KEGG和神经科学信息框架--为我们的INIA团队提供了一个很好的研究机会。但这些资源往往有一个陡峭的学习曲线，很难一起使用。我们的目标之一是将这些资源与对NIAAA研究人员有用的大型新数据集组合在一起。INIA翻译Web服务核心有以下目标：（1）处理、分析和分发两个INIA联盟的大量数组和下一代数据集;（2）将来自啮齿动物、非人类灵长类动物和人类的INIA联盟数据集集成到GeneNetwork中，并显著增强双向翻译查询工具;（3）为其他INIA项目和核心提供生物信息学、遗传学和下一代基因组工具方面的数据库支持、培训和文档。

DESCRIPTION (provided by applicant): A key objective of the INIA programs is to transform research on causes, prevention, and treatment of alcoholism. Integration of data sets and analytic methods across a broad spectrum of research is critical to success. This INIA UOI Core application is built on the success of several powerful INIA web services and data resources, including GeneNetwork, WebGestalt, and the Ontological Discovery Environment (ODE). However, our aims in this renewal are a direct outgrowth of rapid changes in genomics and neuroscience, in particular, next-generation sequencing. A theme of this core is innovation by integration. The far more pervasive use of web services in neuroscience over the last five years - Allen Brain Atlas, DAVID, ODE, Galaxy, GeneNetwork, GeneWiki, KEGG, and the Neuroscience Information Framework - represents a great research opportunity for our INIA teams. But these resources often have a steep learning curve and are difficult to use together. One of our goals is to assemble these resources together with large new data sets in a context useful to NIAAA researchers. The INIA Translational Web Services core has these aims: (1) Process, analyze, and distribute massive array and next-generation data sets for both INIA consortia; (2) Integrate INIA consortia data sets from rodents, non-human primates, and humans into GeneNetwork and significantly enhance tools for bidirectional translational queries; (3) Provide database support, training, and documentation in bioinformatics, genetics, and next-gen genomic tools to other INIA projects and cores.