INIA: Bioinformatics Core

描述(由申请人提供)：INIA项目的一个关键目标是改变对酒精中毒的原因、预防和治疗的研究。在广泛的研究范围内整合数据集和分析方法是成功的关键。这个INIA UOI核心应用程序建立在几个强大的INIA Web服务和数据资源的成功基础上，包括GeneNetwork、WebGestalt和Ontology Discovery Environment(ODE)。然而，我们在这次更新中的目标是基因组学和神经科学的快速变化的直接产物，特别是下一代测序。这一核心的一个主题是融合创新。在过去五年中，网络服务在神经科学中的广泛使用--Allen Brain Atlas、David、ODE、Galaxy、GeneNetwork、GeneWiki、KEGG和神经科学信息框架--对我们的INIA团队来说是一个巨大的研究机会。但这些资源往往有一个陡峭的学习曲线，很难一起使用。我们的目标之一是在对NIAAA研究人员有用的背景下，将这些资源与大型新数据集结合在一起。INIA翻译网络服务核心有以下目标：(1)处理、分析和分发INIA联合体的海量阵列和下一代数据集；(2)将INIA联合体来自啮齿动物、非人灵长类和人类的数据集整合到GeneNetwork中，并显著增强双向翻译查询的工具；(3)为INIA的其他项目和核心提供生物信息学、遗传学和下一代基因组工具方面的数据库支持、培训和文档。

DESCRIPTION (provided by applicant): A key objective of the INIA programs is to transform research on causes, prevention, and treatment of alcoholism. Integration of data sets and analytic methods across a broad spectrum of research is critical to success. This INIA UOI Core application is built on the success of several powerful INIA web services and data resources, including GeneNetwork, WebGestalt, and the Ontological Discovery Environment (ODE). However, our aims in this renewal are a direct outgrowth of rapid changes in genomics and neuroscience, in particular, next-generation sequencing. A theme of this core is innovation by integration. The far more pervasive use of web services in neuroscience over the last five years - Allen Brain Atlas, DAVID, ODE, Galaxy, GeneNetwork, GeneWiki, KEGG, and the Neuroscience Information Framework - represents a great research opportunity for our INIA teams. But these resources often have a steep learning curve and are difficult to use together. One of our goals is to assemble these resources together with large new data sets in a context useful to NIAAA researchers. The INIA Translational Web Services core has these aims: (1) Process, analyze, and distribute massive array and next-generation data sets for both INIA consortia; (2) Integrate INIA consortia data sets from rodents, non-human primates, and humans into GeneNetwork and significantly enhance tools for bidirectional translational queries; (3) Provide database support, training, and documentation in bioinformatics, genetics, and next-gen genomic tools to other INIA projects and cores.