Pilot Research Project Core NIDA "COE" Transcriptomics, Systems Genetics and the Addictome

成瘾是一种高度复杂的疾病，其风险因素包括基因变异和基因差异。 发展、性和环境。精准医学改善药物治疗的长期潜力 而预防依赖于更好地了解遗传学、药物、脑细胞和 神经回路相互作用，影响行为。有严重的技术障碍阻碍了研究人员 和临床医生在成瘾研究中纳入更强大的计算和预测方法。 NIDA P30 OMICS、系统遗传学和智囊团卓越核心中心的宗旨 是授权和培训由NIH、NIDA、NIAAA和其他联邦和州机构支持的研究人员 使用更多定量和可测试的方法来分析遗传、表观遗传和环境因素 影响药物滥用风险和治疗。我们的试点核心正在促进早期职业生涯中的新合作 成瘾研究领域的调查人员。总而言之，该中心是一个全国性的可复制资源 成瘾研究。我们正在集中、归档、分发、分析和集成高质量的数据， 元数据，与许多其他研究团队合作，使用开放软件系统。我们的目标是 帮助建立一个NIDA Addicome门户网站，其中将包括与成瘾相关的所有基因组研究 研究。

Addiction is a highly complex disease with risk factors that include genetic variants and differences in development, sex, and environment. The long term potential of precision medicine to improve drug treatment and prevention depends on gaining a much better understanding how genetics, drugs, brain cells, and neuronal circuitry interact to influence behavior. There are serious technical barriers that prevent researchers and clinicians from incorporating more powerful computational and predictive methods in addiction research. The purpose of the NIDA P30 Core Center of Excellence in Omics, Systems Genetics, and the Addictome is to empower and train researchers supported by NIH, NIDA, NIAAA, and other federal and state institutions to use more quantitative and testable ways to analyze genetic, epigenetic, and the environmental factors that influence drug abuse risk and treatment. Our Pilot core is catalyzing new collaborations among early career investigators in the field of addiction research. In sum the Center is a national resource for reproducible research in addiction. We are centralizing, archiving, distributing, analyzing and integrating high quality data, metadata, using open software systems in collaboration with many other teams of researchers. Our goal is to help build toward an NIDA Addictome Portal that will include all genomic research relevant to addiction research.