Pilot Research Project Core NIDA "COE" Transcriptomics, Systems Genetics and the Addictome

试点研究项目核心 NIDA“COE”转录组学、系统遗传学和成瘾组

• 批准号: 10177982
• 负责人: ROBERT W. WILLIAMS
• 金额: $ 2.78万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177982
• 关键词: Applications Grants; Archives; Biological Models; Collaborations; Communities; Complex; Data; Development; Disease; Drug abuse; Educational workshop; Ensure; Environment; Environmental Risk Factor; Epigenetic Process; Equipment; Faculty; Feedback; Funding; Generations; Genetic; Genetic Variation; Genomics; Goals; Grant; Hybrids; Informatics; Institution; Laboratories; Lead; Letters; Metadata; Methods; Modeling; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Pharmaceutical Preparations; Pharmacotherapy; Pilot Projects; Prevention; Proteomics; Publications; Rat Strains; Rattus; Recruitment Activity; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Running; Sum; System; Systems Analysis; Systems Biology; Technology; Testing; Tissues; Training; United States National Institutes of Health; Work; addiction; base; behavior influence; biobank; brain cell; career; design; follow-up; genetic variant; improved; innovation; meetings; member; metabolomics; multiple omics; neuronal circuitry; new technology; novel; precision medicine; prevent; programs; ranpirnase; relating to nervous system; response; sex; single-cell RNA sequencing; software systems; success; symposium; transcriptome; transcriptomics

Addiction is a highly complex disease with risk factors that include genetic variants and differences in development, sex, and environment. The long term potential of precision medicine to improve drug treatment and prevention depends on gaining a much better understanding how genetics, drugs, brain cells, and neuronal circuitry interact to influence behavior. There are serious technical barriers that prevent researchers and clinicians from incorporating more powerful computational and predictive methods in addiction research. The purpose of the NIDA P30 Core Center of Excellence in Omics, Systems Genetics, and the Addictome is to empower and train researchers supported by NIH, NIDA, NIAAA, and other federal and state institutions to use more quantitative and testable ways to analyze genetic, epigenetic, and the environmental factors that influence drug abuse risk and treatment. Our Pilot core is catalyzing new collaborations among early career investigators in the field of addiction research. In sum the Center is a national resource for reproducible research in addiction. We are centralizing, archiving, distributing, analyzing and integrating high quality data, metadata, using open software systems in collaboration with many other teams of researchers. Our goal is to help build toward an NIDA Addictome Portal that will include all genomic research relevant to addiction research.

成瘾是一种高度复杂的疾病，其危险因素包括基因变异和基因差异