Studies in Translational Regenerative Medicine

项目摘要/摘要 再生医学(RM)领域需要一种新型的研究人员，受过良好的基础RM培训 概念和方法，能够将人类生物学和工程系统与挑战意识相结合 参与推进基础研究、监管科学和临床翻译。我们T32的总体目标是 博士前培训项目“转化再生医学研究”将继续致力于 培养下一代受过多学科培训的研究科学家和工程师，他们将领导 新的多样化研究团队为现实世界的健康问题设计解决方案并推动RM 菲尔德。能够将最先进的多学科基础科学培训与基础设施和知识联系起来 加速RM技术转换所需的基础是关键优势。到目前为止，这个T32程序已经 为10名博士生提供了成为独立RM研究人员的工具。与教职员工的一致 我们T32项目第一周期培养博士后、博士后和职业早期教师的成功记录 超额完成目标。受训人员积累了一份令人印象深刻的优质出版物清单(66份已出版/14份正在进行中)和 在地方、国家和国际会议上的口头和海报演示(103)。重要的是，100%的 指定的受训人员目前正在攻读博士学位或已获得博士学位。六 学员完成了他们的T32培训和博士答辩，并成功地进入学术或非 学术生涯。在这些人中，4人(66%)仍然明确地专注于RM研究。招募了三人(50%)， 因为他们接受过T32培训，所以进入了拥有广泛RM投资组合的行业职位。WFIRM的独特性 基础设施为从基础临床前研究到转化性研究提供设施和专业知识 通过二期临床试验。WFIRM的多学科培训包括一系列活动，包括 教学课程，参与尖端团队科学，以及从事学术研究的新机会， 政府和工业外部设备。新计划强调职业和职业发展， 包括项目和时间管理、拨款撰写、监管科学、GMP制造和科学 伦理道德。该计划有3个与NIBIB一致的重点领域：1)生物材料；2)使能技术(生物印刷， 芯片上的身体、成像和多流体)；以及3)干细胞/细胞疗法应用于一种或多种应用 领域：1)心血管；2)肌肉骨骼；3)胃肠/内分泌；4)泌尿外科。实习生是 选自7个WFGS中的4个：生物医学工程、分子和细胞生物科学、神经科学或 综合生理学和药理学。经过共同的第一年课程(每个赛道都是独一无二的)，学员 确定10位主要导师(19位指导教师)中的一位，参加专门的RM课程并选择 毕业委员会。包括经验丰富的初级导师(10名)、受训导师(6名)和荣休导师 (3)具有职业生涯指导经验的导师是项目的一个独特方面。该计划由以下人员审查 由杰出的学术、政府和行业成员组成的内部和外部咨询委员会。

Project Summary/Abstract The Regenerative Medicine (RM) field requires a new type of researcher, well-trained in fundamental RM concepts and methods, able to integrate human biology and engineered systems with awareness of challenges involved in advancing basic research, regulatory science, and clinical translation. The overall goal of our T32 pre-doctoral training program, “Studies in Translational Regenerative Medicine”, remains committed to developing next generation multidisciplinary trained research scientists and engineers, who will lead new diverse research teams designing solutions to real-world health problems and advance the RM field. Ability to link state-of-the-art multidisciplinary basic science training to the infrastructure and knowledge base required to accelerate translation of RM technologies are key strengths. To date, this T32 program has provided 10 PhD trainees the tools to become independent RM researchers. Consistent with faculty's successful record of educating pre-, post-doctoral and early-career faculty, the first cycle of our T32 program exceeded goals. Trainees accrued an impressive list of quality publications (66 published/14 in process) and oral and poster presentations (103) at local, national and international meetings. Importantly, 100% of appointed trainees are currently working on their PhD requirements or have obtained their PhD degrees. Six trainees completed their T32 training and PhD defense and successfully moved on to academic or non- academic careers. Of these, 4 (66%) remain in explicitly focused RM research. Three (50%) were recruited, because of their T32 training, into industry positions with extensive RM portfolios. WFIRM's distinctive infrastructure provides the facilities and expertise for translational studies ranging from basic preclinical studies through Phase 2 clinical trials. WFIRM's multidisciplinary training includes a range of activities, including didactic courses, participation in cutting-edge team science, and new opportunities to engage in academic, government, and industrial externships. The new program emphasizes professional and career development, including project and time management, grant writing, regulatory science, GMP manufacturing, and scientific ethics. The program has 3 NIBIB-aligned focus areas: 1) biomaterials; 2) enabling technologies (bioprinting, body-on-a-chip, imaging & multifluidics); and 3) stem cells/cell therapies applied to one or more application areas: 1) cardiovascular; 2) musculoskeletal; 3) gastrointestinal/endocrinal; and 4) urological. Trainees are selected from 4 of 7 WFGS tracks: Biomedical Engineering, Molecular & Cellular Biosciences, Neuroscience or Integrative Physiology and Pharmacology. After a common 1st year curriculum (unique to each track), trainees identify one of 10 primary mentors (of 19 mentoring faculty), take specialized RM courses and choose a graduate committee. Inclusion of seasoned Primary Mentors (10), Mentors-in-Training (6), and Emeritus Mentors (3) with career-long mentoring experience is a unique program aspect. The program is reviewed by Internal and External Advisory Boards composed of prominent academic, government, and industry members.