Studies in Translational Regenerative Medicine

描述(由申请人提供)：再生医学包括组织工程学和自我修复，该学科已成为一门极具价值的学科，对改善人类健康具有巨大的影响。虽然维克森林再生医学研究所(WFIRM)在其短暂的存在中取得了巨大的成功，但我们缺乏一个完整的机制来支持代表下一代再生医学研究人员的博士前学生的培训。因此，我们寻求对新的T32培训计划的支持，以满足这一需求。拟议的项目是WFIRM正在进行的多学科合作的合乎逻辑的延伸，所有这些都位于维克森林医学院市中心校区的一座新的最先进的建筑中。WFIRM拥有独特的基础设施，为翻译研究提供设施和专业知识，从基本的临床前研究结果一直到第二阶段临床试验。培训将包括传统的教学课程工作，各种WFIRM范围的培训活动，参与尖端研究项目，拨款撰写和科学演示，以及接触再生医学的伦理问题。将有6个研究领域：1)泌尿外科~2)心血管~3)肌肉骨骼~4)内分泌组织~5)干细胞~6)生物材料/使能技术。每个重点领域至少有五名具有互补专业知识的教职员工，他们将作为共同导师参与研究生的培训和监督。学生将从WFU研究生院新配置的结构中的3个课程中挑选：分子和细胞生物科学、生物医学工程或综合生理学和药理学。在共同的第一年课程(每个课程都是独一无二的)之后，学生们将从我们的10位主要导师中挑选一位(总共19位项目教师)，选修两门基于再生医学的额外课程，并选择一个研究生委员会来指导学生完成他们的论文工作。项目主任乔治·克罗斯博士对培训项目的管理负有最终责任，由安东尼·阿塔拉博士(副主任)和由经验丰富的资深培训人员组成的执行委员会提供协助。拟议的导师结构的一个新方面是包括经验丰富的教员(初级导师~10名)、年轻的新兴教员(正在培训的导师~5名)和具有长期导师经验的资深教员(荣休导师~4名)。培训计划将由一个内部咨询委员会和一个外部咨询委员会每年进行审查和评估，该委员会的成员拥有管理培训项目以及全国知名的再生医学研究项目的丰富经验。鉴于WFIRM的世界级地位，我们广泛的国内和国际合作，以及我们为反映多学科培训的需求而对我们的研究生课程进行的重组，这一申请提供了一个独特的培训机会。因此，这项建议是及时的、深思熟虑的。 计划，并专门设计，以满足再生医学许多方面对训练有素的研究人员的迅速增长的需求。

DESCRIPTION (provided by applicant): Regenerative medicine encompasses both tissue engineering and self-healing, and the discipline has emerged as a hugely valuable one with immense ramifications for improving human health. While the Wake Forest Institute of Regenerative Medicine (WFIRM) has had resounding success in its short existence, we lack an integrated mechanism to support training of the pre-doctoral students that represent the next generation of regenerative medicine researchers. Thus, we seek support for a new T32-training program to meet this need. The proposed program is a logical extension of the ongoing multidisciplinary collaboration of investigators at WFIRM, all located in a new state-of-the-at building on the downtown campus of Wake Forest School of Medicine. WFIRM has a unique infrastructure that provides facilities and expertise for translational studies, from basic preclincal findings all the way through Phase 2 clinical trials. Training will include traditional didactic course work, a variety of WFIRM-wide training activities, participation in cutting-edge research projects, grant writing, and scientific presentations, and exposure to ethical issues in regenerative medicine. There will be 6 areas of research focus: 1) urological~ 2) cardiovascular~ 3) musculoskeletal~ 4) endocrine tissue~ 5) stem cells~ & 6) biomaterials/enabling technologies. Each area of focus contains at least five faculty members with complementary expertise, who will participate in the training and supervision of graduate students as co- mentors. Students will be selected from 3 Tracks within the newly configured structure of the WFU Graduate School: Molecular and Cellular Biosciences, Biomedical Engineering, or Integrative Physiology and Pharmacology. After a common 1st year curriculum (that is unique to each track), students will identify one of our 10 primary mentors (of the 19 total program faculty), take two additional regenerative medicine-based courses, and choose a graduate committee that will guide the student through their thesis work. The Program Director, Dr. George Christ, has ultimate responsibility for the administration of the Training program, assisted by Dr. Anthony Attala (the Associate Director) and an Executive Committee composed of senior experienced trainers. A novel aspect of the proposed mentoring structure is the inclusion of seasoned faculty (Primary Mentors~ 10), young rising faculty (Mentors in Training~ 5), and senior faculty that have career-long mentoring experience (Emeritus Mentors~ 4). The training program will be reviewed and evaluated annually by an Internal Advisory Committee and by an External Advisory Committee, whose members have extensive experience managing training programs as well as nationally renowned research programs in regenerative medicine. Given the world-class stature of WFIRM, our extensive national and international collaborations, and the restructuring of our graduate program to reflect the need for multi-disciplinary training, this application provides a unique training opportunity. As such, this proposal is timely, thoughtfully planned, and specifically designed to meet the burgeoning need for well-trained investigators in the many facets of regenerative medicine.