Behavior Core

行为核心

• 批准号: 10176519
• 负责人: KERRY L TUCKER
• 金额: $ 29.66万
• 依托单位: UNIVERSITY OF NEW ENGLAND
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176519
• 关键词: Acute Pain; Affective; Analgesics; Animal Behavior; Animal Experimentation; Animals; Area; Automation; Behavior; Behavioral; Behavioral Assay; Biological; Biological Assay; Biotechnology; Breeding; Centers of Research Excellence; Clinical Trials; Cognitive; Collaborations; Computer software; Consult; Contracts; Cost Sharing; Development; Drug Industry; Drug Side Effects; Educational workshop; Ensure; Equipment; Experimental Designs; Fee-for-Service Plans; Fees; Foundations; Funding; Future; Genotype; Goals; Human Resources; Image; Industry; Information Dissemination; Institution; Investments; Island; Laboratories; Literature; Maine; Maintenance; Measures; Medical Research; Modeling; Modification; Molecular Genetics; Mus; Nervous System Physiology; Neurosciences; Nociception; Nociceptive Reflex; Operative Surgical Procedures; Pain; Pain management; Performance; Pharmacologic Substance; Pharmacology; Phase; Phenotype; Preparation; Procedures; Protocols documentation; Rattus; Reproducibility; Research; Research Design; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Rodent Model; Scholarship; Sensory; Service delivery model; Services; Standardization; Stream; Structure; Students; Surveys; Systems Analysis; Technical Expertise; Techniques; Technology; Testing; Time; Training; Training Support; Transgenic Animals; Validation; Work; addiction; base; behavior test; behavioral phenotyping; behavioral study; chronic pain; cohort; cost; drug candidate; drug development; drug discovery; equipment acquisition; experience; experimental study; gait examination; industry partner; innovation; insight; instrumentation; knockout animal; model development; mouse model; nociceptive response; novel; optogenetics; outreach; pre-clinical; receptor; service utilization; statistics; success; tool; transmission process

The Behavior Core (BC) is built on a strong foundation of expertise in assessing behaviors to advance the pain field and early-stage drug discovery and development. Behavior Core Director Dr. Edward Bilsky is a well- established behavioral pharmacologist who has focused on developing novel analgesics for the treatment of acute and chronic pain. In addition to receiving numerous grants for his research, Dr. Bilsky has worked with biotechnology and pharmaceutical companies, and co-founded two companies, one of which has successfully brought a drug candidate into clinical trials. The BC’s experienced staff provides training and support for an extensive menu of behaviors related to pain and potential analgesic drug side-effects. The BC provides (a) standardized protocols and training between laboratories to reduce variability and increase reproducibility and validity for measures of nociceptive behavior; (b) advanced training and model development and validation (e.g., alternatives to reflexive nociceptive responses such as affective, cognitive and pain-suppressed readouts); (c) a centralized space for many behavioral assays and surgical procedures. During Phase I, the BC team successfully supported and trained COBRE personnel, consistently receiving outstanding user reviews on the services it provides. These services will continue to be provided to COBRE Project Leaders and other investigators during Phase II. In addition the BC will increase its offerings to meet the growing needs of COBRE investigators. New developments include expanded breeding and genotyping services to support the increased utilization of genetically modified mouse models, and support for investigators’ utilization of optogenetic approaches in behavioral studies. Continued training of Core research staff will be provided to ensure that the highest level of innovation and support can be provided to COBRE investigators. In expanding the Core services, the BC Director has worked closely with neighboring COBRE and INBRE supported research cores at the Maine Medical Research Institute and the Mount Desert Island Biological Laboratory. This coordination with other regional resources will allow the BC to broaden its user base as it prepares for long-term sustainability. Sustainability will also be facilitated by implementing a fee-for-service model and by continuing to work with industry partners. The Behavior Core is indispensible to the success of the research efforts of COBRE investigators. Continued investments in its capabilities will allow the Core to provide the latest experimental tools in animal research and help the Core transition to fiscal independence. Through utilization of these services, researchers and trainees are able to test novel compounds for the treatment of pain while gaining key insights into the function of the nervous system and mechanisms of acute and chronic pain.

行为核心（BC）建立在评估行为以促进痛苦方面的强大专业知识基础上 现场和早期药物发现与发展。行为核心主任爱德华·比尔斯基（Edward Bilsky）是一个很好的 已建立的行为药理学家，他致力于开发新型的镇痛药来治疗 急性和慢性疼痛。比尔斯基博士除了获得许多赠款外，还与 生物技术和制药公司，并共同创立了两家公司，其中一家成功成功 购买了候选药物进行临床试验。卑诗省经验丰富的员工为 与疼痛和潜在的镇痛药副作用有关的广泛行为菜单。卑诗省提供（a） 实验室之间的标准化协议和培训，以降低可变性并提高可重复性和 测量伤害性行为的有效性； （b）高级培训和模型开发和验证 （例如，反思性伤害性反应的替代方法，例如情感，认知和疼痛抑制 读数）; （c）许多行为测定和手术程序的集中空间。在第一阶段， BC团队成功支持和训练有素的Cobre人员，始终接收出色的用户 评论其提供的服务。这些服务将继续提供给Cobre项目负责人 以及第二阶段的其他研究人员。此外，卑诗省将增加其产品以满足不断增长的需求 毛绒调查员。新的发展包括扩大的育种和基因分型服务以支持 一般修改的鼠标模型的利用增加，并支持研究人员的利用 行为研究中的光遗传学方法。将继续对核心研究人员进行培训 确保可以向毛cor虫调查人员提供最高水平的创新和支持。在扩展中 核心服务，卑诗省董事已与邻近的毛病和inbre紧密合作。 缅因州医学研究所和荒岛山生物实验室的研究核心。 与其他区域资源的这种协调将使卑诗省在准备时扩大其用户群 长期可持续性。可持续性也将通过实施费用的服务模型来准备 继续与行业合作伙伴合作。行为核心对研究的成功不可或缺 毛con研究者的努力。继续投资其功能将使核心能够提供 动物研究中的最新实验工具，并有助于核心向财政独立过渡。通过 这些服务的利用，研究人员和受训者能够测试新颖的化合物以治疗 疼痛，同时获得对神经系统功能以及急性和慢性机制的功能的关键见解 疼痛。