Behavior Core

行为核心

• 批准号: 10176519
• 负责人: KERRY L TUCKER
• 金额: $ 29.66万
• 依托单位: UNIVERSITY OF NEW ENGLAND
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176519
• 关键词: Acute Pain; Affective; Analgesics; Animal Behavior; Animal Experimentation; Animals; Area; Automation; Behavior; Behavioral; Behavioral Assay; Biological; Biological Assay; Biotechnology; Breeding; Centers of Research Excellence; Clinical Trials; Cognitive; Collaborations; Computer software; Consult; Contracts; Cost Sharing; Development; Drug Industry; Drug Side Effects; Educational workshop; Ensure; Equipment; Experimental Designs; Fee-for-Service Plans; Fees; Foundations; Funding; Future; Genotype; Goals; Human Resources; Image; Industry; Information Dissemination; Institution; Investments; Island; Laboratories; Literature; Maine; Maintenance; Measures; Medical Research; Modeling; Modification; Molecular Genetics; Mus; Nervous System Physiology; Neurosciences; Nociception; Nociceptive Reflex; Operative Surgical Procedures; Pain; Pain management; Performance; Pharmacologic Substance; Pharmacology; Phase; Phenotype; Preparation; Procedures; Protocols documentation; Rattus; Reproducibility; Research; Research Design; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Rodent Model; Scholarship; Sensory; Service delivery model; Services; Standardization; Stream; Structure; Students; Surveys; Systems Analysis; Technical Expertise; Techniques; Technology; Testing; Time; Training; Training Support; Transgenic Animals; Validation; Work; addiction; base; behavior test; behavioral phenotyping; behavioral study; chronic pain; cohort; cost; drug candidate; drug development; drug discovery; equipment acquisition; experience; experimental study; gait examination; industry partner; innovation; insight; instrumentation; knockout animal; model development; mouse model; nociceptive response; novel; optogenetics; outreach; pre-clinical; receptor; service utilization; statistics; success; tool; transmission process

The Behavior Core (BC) is built on a strong foundation of expertise in assessing behaviors to advance the pain field and early-stage drug discovery and development. Behavior Core Director Dr. Edward Bilsky is a well- established behavioral pharmacologist who has focused on developing novel analgesics for the treatment of acute and chronic pain. In addition to receiving numerous grants for his research, Dr. Bilsky has worked with biotechnology and pharmaceutical companies, and co-founded two companies, one of which has successfully brought a drug candidate into clinical trials. The BC’s experienced staff provides training and support for an extensive menu of behaviors related to pain and potential analgesic drug side-effects. The BC provides (a) standardized protocols and training between laboratories to reduce variability and increase reproducibility and validity for measures of nociceptive behavior; (b) advanced training and model development and validation (e.g., alternatives to reflexive nociceptive responses such as affective, cognitive and pain-suppressed readouts); (c) a centralized space for many behavioral assays and surgical procedures. During Phase I, the BC team successfully supported and trained COBRE personnel, consistently receiving outstanding user reviews on the services it provides. These services will continue to be provided to COBRE Project Leaders and other investigators during Phase II. In addition the BC will increase its offerings to meet the growing needs of COBRE investigators. New developments include expanded breeding and genotyping services to support the increased utilization of genetically modified mouse models, and support for investigators’ utilization of optogenetic approaches in behavioral studies. Continued training of Core research staff will be provided to ensure that the highest level of innovation and support can be provided to COBRE investigators. In expanding the Core services, the BC Director has worked closely with neighboring COBRE and INBRE supported research cores at the Maine Medical Research Institute and the Mount Desert Island Biological Laboratory. This coordination with other regional resources will allow the BC to broaden its user base as it prepares for long-term sustainability. Sustainability will also be facilitated by implementing a fee-for-service model and by continuing to work with industry partners. The Behavior Core is indispensible to the success of the research efforts of COBRE investigators. Continued investments in its capabilities will allow the Core to provide the latest experimental tools in animal research and help the Core transition to fiscal independence. Through utilization of these services, researchers and trainees are able to test novel compounds for the treatment of pain while gaining key insights into the function of the nervous system and mechanisms of acute and chronic pain.

行为核心（BC）是建立在评估行为的专业知识的坚实基础上，以促进疼痛 领域和早期阶段的药物发现和开发。行为核心主任爱德华·比尔斯基博士是一个很好的- 他是一位知名的行为药理学家，专注于开发新型镇痛药，用于治疗 急性和慢性疼痛。除了获得大量的研究赠款外，比尔斯基博士还与 生物技术和制药公司，并共同创办了两家公司，其中一家已成功地 将一种候选药物带入临床试验不列颠哥伦比亚省经验丰富的工作人员提供培训和支持， 与疼痛和潜在镇痛药物副作用相关的广泛行为菜单。《巴塞尔公约》规定：（a） 实验室之间的标准化方案和培训，以减少变异性并提高重现性， 伤害性行为测量的有效性;（B）高级培训和模型开发与验证 (e.g.,替代反射性伤害性反应，如情感、认知和疼痛抑制 读数）;（c）用于许多行为测定和外科手术的集中空间。在第一阶段， 业务连续性团队成功地支持和培训了COBRE人员， 评论它提供的服务。这些服务将继续提供给COBRE项目负责人 和其他研究者在第二阶段。此外，BC将增加其产品，以满足不断增长的需求 COBRE的调查员。新的发展包括扩大育种和基因分型服务， 转基因小鼠模型的使用增加，并支持研究人员利用 行为研究中的光遗传学方法。将继续培训核心研究人员， 确保为COBRE调查人员提供最高水平的创新和支持。坚持扩大 在核心服务方面，业务连续性主任与邻近的COBRE和INBRE密切合作， 缅因州医学研究所和芒特沙漠岛生物实验室的研究核心。 与其他区域资源的这种协调将使巴塞尔公约在筹备 长期可持续性。还将通过实施收费服务模式和 继续与行业合作伙伴合作。行为核心是研究成功的必要条件 COBRE调查人员的努力。继续对其能力进行投资将使核心能够提供 最新的动物研究实验工具，并帮助核心过渡到财政独立。通过 利用这些服务，研究人员和受训人员能够测试新的化合物，用于治疗 疼痛，同时获得神经系统的功能和机制的关键见解急性和慢性 痛苦