Integrative Program in Complex Biological System (ipCBS)

复杂生物系统综合计划（ipCBS）

• 批准号: 10178009
• 负责人: Wallace Marshall
• 金额: $ 18.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10178009
• 关键词: complex biological systems; programs

PROJECT SUMMARY / ABSTRACT This is an application for renewal of the Integrative Program in Complex Biological Systems (ipCBS), a graduate training program providing a specialization for students that are members of the Biophysics and Bioinformatics group. The ipCBS is a comprehensive interdisciplinary program specifically designed around the engineering of complex biological systems (“synthetic biology”). At a fundamental level, this program seeks to solve the sociological and linguistic problems associated with training scientists and engineers to be simultaneously conversant in the multiple languages of biology, mathematics, physics, and engineering. A key feature of the ipCBS is the fact that UCSF is medical campus, so that our students can exploit opportunities to explore and engineer biological complexity in the context of health and disease. Over the past grant period, the ipCBS has continued to develop and evolve the curriculum, especially in the area of hands-on project based, experiential learning. As a result, a purpose-built Graduate Teaching Laboratory was constructed as a direct outcome of this training program, and projects-based courses conducted in the spirit of Cold Spring Harbor / Woods Hole, have become a keystone of the graduate first year experience. The key points of the ipCBS are as follows: • Long term objective: To provide critical training necessary to lead innovation in a synthetic and systems biology research environment driven by team-based interdisciplinary approaches to biomedical science and human health and dominated by large-scale and high complexity data characteristic of precision medicine. • Approach: The ipCBS holds four core principles as the basis for graduate training. 1) Focus on the “design principles” of biological organization, from the molecular to the cellular level. 2) Focus on the challenge of engineering synthetic circuitry within complex systems from an interdisciplinary team-based perspective. 3) Focus on breaking down the language/sociology barrier. 4) Focus on mentoring.

项目摘要/摘要 这是复杂生物系统综合计划(IpCBS)的续签申请， 研究生培训计划为生物物理学和生物物理学专业的学生提供专业 生物信息学小组。IpCBS是一个全面的跨学科计划，专门围绕 复杂生物系统工程(“合成生物学”)。在根本层面上，该计划寻求 解决与培训科学家和工程师相关的社会学和语言学问题 同时精通生物、数学、物理和工程等多种语言。一把钥匙 IpCBS的特点是加州大学旧金山分校是医学院，所以我们的学生可以利用机会 在健康和疾病的背景下探索和设计生物复杂性。在过去的授权期内， IPCBS继续开发和发展课程，特别是在以实践项目为基础的领域， 体验式学习。为此，专门建设了研究生教学实验室，作为一个直接的 本培训计划的结果，以及本着冷泉港精神开展的基于项目的课程/ 伍兹霍尔，已经成为毕业生第一年的重点体验。 IpCBS的要点如下： ·长期目标：提供必要的关键培训，以引领综合和系统创新 由基于团队的跨学科方法推动的生物医学科学和生物研究环境 以人类健康和大范围、高复杂性的数据为主导的精准医学的特点。 ·方法：ipCBS将四项核心原则作为研究生培训的基础。1)重点做好《设计》 生物组织的“原则”，从分子到细胞层面。2)关注挑战 从跨学科团队的角度设计复杂系统中的合成电路。3) 专注于打破语言/社会学的障碍。4)注重辅导。