Integrative Program in Complex Biological System (ipCBS)

复杂生物系统综合计划（ipCBS）

• 批准号: 10440389
• 负责人: Wallace Marshall
• 金额: $ 17.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440389
• 关键词: complex biological systems; programs

PROJECT SUMMARY / ABSTRACT This is an application for renewal of the Integrative Program in Complex Biological Systems (ipCBS), a graduate training program providing a specialization for students that are members of the Biophysics and Bioinformatics group. The ipCBS is a comprehensive interdisciplinary program specifically designed around the engineering of complex biological systems (“synthetic biology”). At a fundamental level, this program seeks to solve the sociological and linguistic problems associated with training scientists and engineers to be simultaneously conversant in the multiple languages of biology, mathematics, physics, and engineering. A key feature of the ipCBS is the fact that UCSF is medical campus, so that our students can exploit opportunities to explore and engineer biological complexity in the context of health and disease. Over the past grant period, the ipCBS has continued to develop and evolve the curriculum, especially in the area of hands-on project based, experiential learning. As a result, a purpose-built Graduate Teaching Laboratory was constructed as a direct outcome of this training program, and projects-based courses conducted in the spirit of Cold Spring Harbor / Woods Hole, have become a keystone of the graduate first year experience. The key points of the ipCBS are as follows: • Long term objective: To provide critical training necessary to lead innovation in a synthetic and systems biology research environment driven by team-based interdisciplinary approaches to biomedical science and human health and dominated by large-scale and high complexity data characteristic of precision medicine. • Approach: The ipCBS holds four core principles as the basis for graduate training. 1) Focus on the “design principles” of biological organization, from the molecular to the cellular level. 2) Focus on the challenge of engineering synthetic circuitry within complex systems from an interdisciplinary team-based perspective. 3) Focus on breaking down the language/sociology barrier. 4) Focus on mentoring.

项目总结/摘要 这是一个申请更新的综合计划在复杂的生物系统（ipCBS）， 研究生培训计划为生物物理学成员的学生提供专业化， 生物信息学小组。ipCBS是一个全面的跨学科计划，专门围绕 复杂生物系统工程（“合成生物学”）。在基本层面上，该计划旨在 解决与培养科学家和工程师相关的社会学和语言学问题， 同时精通生物学、数学、物理学和工程学的多种语言。一个关键 ipCBS的特点是，UCSF是医学校园的事实，使我们的学生可以利用机会， 在健康和疾病的背景下探索和设计生物复杂性。在过去的资助期内， ipCBS继续开发和发展课程，特别是在基于实践项目的领域， 体验式学习因此，一个专门建设的研究生教学实验室被建成作为一个直接的 本培训计划的成果，以及本着冷泉港/ 伍兹霍尔，已成为研究生第一年的经验基石。 ipCBS的要点如下： ·长期目标：提供引领合成和系统创新所需的关键培训 生物学研究环境由基于团队的跨学科方法驱动，以生物医学科学和 以精准医学为特征的大规模、高复杂度数据为主导。 方法：ipCBS拥有四个核心原则作为研究生培训的基础。1)专注于“设计 从分子到细胞水平，生物组织的“原则”。2)专注于挑战 从跨学科团队的角度在复杂系统中设计合成电路。第三章 打破语言/社会学障碍。4)专注于指导。