Integrative Program in Complex Biological System (ipCBS)

项目概要/摘要 这是复杂生物系统综合计划 (ipCBS) 更新的申请， 研究生培训计划为生物物理学和生物物理学成员的学生提供专业化 生物信息学组。 ipCBS 是一个综合性跨学科项目，专门围绕 复杂生物系统工程（“合成生物学”）。从根本上讲，该计划旨在 解决与培训科学家和工程师相关的社会学和语言问题 同时精通生物学、数学、物理学和工程学的多种语言。一把钥匙 ipCBS 的特点是 UCSF 是医学院，因此我们的学生可以利用机会 在健康和疾病的背景下探索和设计生物复杂性。在过去的资助期内， ipCBS 不断开发和发展课程，特别是在基于实践项目的领域， 体验式学习。因此，专门建立了研究生教学实验室作为直接 本次培训计划的成果，以及本着冷泉港精神开展的基于项目的课程/ 伍兹霍尔已经成为研究生第一年经历的基石。 ipCBS的要点如下： • 长期目标：提供引领合成和系统创新所需的关键培训 由基于团队的跨学科生物医学方法驱动的生物学研究环境 人类健康和精准医疗以大规模、高复杂性数据为主导。 • 方法：ipCBS 将四项核心原则作为研究生培训的基础。 1）注重“设计” 从分子到细胞水平的生物组织原理”。 2）关注挑战 从跨学科团队的角度在复杂系统中设计合成电路。 3） 专注于打破语言/社会学障碍。 4）注重辅导。

PROJECT SUMMARY / ABSTRACT This is an application for renewal of the Integrative Program in Complex Biological Systems (ipCBS), a graduate training program providing a specialization for students that are members of the Biophysics and Bioinformatics group. The ipCBS is a comprehensive interdisciplinary program specifically designed around the engineering of complex biological systems (“synthetic biology”). At a fundamental level, this program seeks to solve the sociological and linguistic problems associated with training scientists and engineers to be simultaneously conversant in the multiple languages of biology, mathematics, physics, and engineering. A key feature of the ipCBS is the fact that UCSF is medical campus, so that our students can exploit opportunities to explore and engineer biological complexity in the context of health and disease. Over the past grant period, the ipCBS has continued to develop and evolve the curriculum, especially in the area of hands-on project based, experiential learning. As a result, a purpose-built Graduate Teaching Laboratory was constructed as a direct outcome of this training program, and projects-based courses conducted in the spirit of Cold Spring Harbor / Woods Hole, have become a keystone of the graduate first year experience. The key points of the ipCBS are as follows: • Long term objective: To provide critical training necessary to lead innovation in a synthetic and systems biology research environment driven by team-based interdisciplinary approaches to biomedical science and human health and dominated by large-scale and high complexity data characteristic of precision medicine. • Approach: The ipCBS holds four core principles as the basis for graduate training. 1) Focus on the “design principles” of biological organization, from the molecular to the cellular level. 2) Focus on the challenge of engineering synthetic circuitry within complex systems from an interdisciplinary team-based perspective. 3) Focus on breaking down the language/sociology barrier. 4) Focus on mentoring.