ShEEP Request for Enabling 3D Nano-Printer Technology

ShEEP 请求启用 3D 纳米打印机技术

• 批准号: 10179144
• 负责人: JASON A WERTHEIM
• 金额: --
• 依托单位: SOUTHERN ARIZONA VA HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10179144
• 关键词: 3-Dimensional; 3D Print; Amyotrophic Lateral Sclerosis; Arizona; Asia; Award; Biological; Biomedical Engineering; Blood Vessels; Blood capillaries; Buffaloes; Caliber; Cell Differentiation process; Cells; Cellular biology; Characteristics; Chemicals; Cities; Clostridium difficile; Collaborations; Development; Devices; Energy Transfer; Ensure; Enzyme Inhibitor Drugs; Equipment; Fees; Funding; Geometry; Glycoproteins; Goals; Growth Factor; Healthcare; Healthcare Systems; Heart Diseases; Human Biology; Ink; Institution; Kidney; Kidney Failure; Lead; Length; Ligands; Light; Liver Dysfunction; Location; Maryland; Medical center; Methods; Microbiology; Microfluidic Microchips; Microfluidics; Minor; Mississippi; Molecular; Myeloma Proteins; Nephrons; New York; Nonprofit Organizations; Oligonucleotides; Pattern; Peptides; Perfusion; Pharmaceutical Preparations; Polymers; Printing; Process; Proteins; Pulmonary Fibrosis; Reproducibility; Research; Research Personnel; Resolution; Rivers; Scanning; Series; Services; Sheep; Stem Cell Development; Structure; Surface; System; Technology; Time; Tissue Engineering; Tube; Ultraviolet Rays; Universities; Veterans; Writing; base; biological systems; design; drug discovery; high-throughput drug screening; improved; innovation; instrument; instrumentation; lithography; millimeter; molecular array; nano; nanometer; nanopattern; novel; novel therapeutics; operation; receptor

PROJECT SUMMARY/ABSTRACT The requested instrumentation is an advanced 3D printing system for biological applications that overcomes much of the length-scale limitations of traditional additive manufacturing printing devices. The instrumentation utilizes two tandem technologies of direct molecular printing and ultraviolet light energy transfer to develop bioengineered devices that are uniform, highly controllable and have resolution and length-scales in the nanometer to micrometer-range. The instrumentation is designed to produce controllable, molecular arrays to investigate receptor-ligand, protein-protein, or enzyme-inhibitor interactions with specific applications to: 1) tissue engineering, 2) cell-based studies that influence cellular differentiation and function, 3) drug discovery and 4) microbiology. The primary goal of the instrumentation is to fabricate novel bioengineered devices that consist of arrays of peptides, glycoproteins or oligonucleotides; precisely defined microfluidic channels; and chemically or geometrically tailored biofunctional chips to advance the research domains listed above that cover VA-funded research at the Southern Arizona VA Health Care System (SAVAHCS). Additionally, the 3D nano-printing system may be accessed by investigators at the academic affiliate, the University of Arizona, and other collaborators throughout the region, which will expand the impact of the instrumentation and enhance research collaborations, specifically between the two nearby medical centers and generally throughout the southwestern region.

项目总结/摘要 所要求的仪器是用于生物应用的先进3D打印系统，其克服了 传统增材制造打印设备的长度尺度限制。仪表 利用直接分子印刷和紫外光能转移两种串联技术， 生物工程设备是均匀的，高度可控的，并具有分辨率和长度尺度， 纳米到微米范围。该仪器设计用于生产可控的分子阵列， 研究受体-配体、蛋白质-蛋白质或酶-抑制剂相互作用，具体应用于：1） 组织工程，2）影响细胞分化和功能的基于细胞的研究，3）药物发现， 4)微生物学.仪器的主要目标是制造新型生物工程装置， 肽、糖蛋白或寡核苷酸的阵列;精确定义的微流体通道;以及 或几何定制的生物功能芯片，以推进上述研究领域，涵盖VA资助的 亚利桑那州南部VA医疗保健系统（SAVAHCS）。此外，3D纳米打印系统 可以由学术分支机构亚利桑那大学的研究人员和其他合作者访问 在整个地区，这将扩大仪器的影响，并加强研究合作， 特别是在附近的两个医疗中心之间，以及整个西南地区。