Role of orexin/hypocretin circuit in anesthesia and analgesia
食欲素/下丘脑分泌素回路在麻醉和镇痛中的作用
基本信息
- 批准号:10186780
- 负责人:
- 金额:$ 19.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAbsence of pain sensationAcuteAddressAffectAgitationAlzheimer&aposs DiseaseAnesthesia and AnalgesiaAnesthesia proceduresAnestheticsAnimal BehaviorAnimal TestingAnimalsArousalBiological AssayBrainBrain regionCalciumCaliforniaCardiovascular systemCataplexyChemicalsDeliriumDevelopmentElectric StimulationElectroencephalogramEmotionsEquipmentExhibitsFormalin TestsFoundationsFundingFutureGoalsHabenulaHypothalamic structureInstitutesIsofluraneKnowledgeLateralLinkMapsMental DepressionMentorsMicroscopyMidbrain structureModern MedicineMonitorMusMuscle TonusMuscular AtrophyNarcolepsyNeuroanatomyNeuronsNociceptionOperative Surgical ProceduresOpioidPainPain ThresholdPain managementPathogenesisPatient CarePatientsPatternPerioperative CarePhysiciansRecoveryRegulationReportingResearchRewardsRiskRodentRoleSan FranciscoScientistSiteSleepSleep FragmentationsSolidSpeedSpinal CordSpinal cord posterior hornStressStructureSuggestionSurfaceSystemTechniquesTechnologyTestingTimeTrainingTransgenic MiceUniversitiesWakefulnessWorkaging brainbasal forebrainbasecareercareer developmentclinical practiceexperiencehypocretinin vivo calcium imagingin vivo imagingmidbrain central gray substancemultidisciplinarynerve supplyneural circuitneural networkneuropsychiatryneurotoxicitynoveloptogeneticspain behaviorpain reliefprofessorrelating to nervous systemrespiratorytoolvoltage
项目摘要
Project Summary/Abstract
With the long-term research goal of advancing anesthesia through developing new tools and techniques for
better anesthetic management and pain control, the candidate focuses his research on elucidating the
mechanisms underlying anesthesia, in particular, the role of hypothalamic orexin (Ox) circuit in anesthesia and
analgesia. How anesthetics interact with brain neural network is still poorly understood. The Ox circuit is
considered to be a master regulator in sleep/wakefulness. The candidate's recent work showed that activation
of Ox neurons with chemogenetic approach facilitates emergence from isoflurane anesthesia and induces
analgesia. Building upon these findings, he proposes to apply optogenetics to specifically activate subsets of Ox
projections to address the underlying mechanisms. The candidate started with mapping the basic neuroanatomy
of the Ox projections in the mouse brain. In his preliminary work, he mapped out three-dimensional Ox
projections using both confocal and lightsheet microscopy and identified three interesting regions he will focus
on in this proposal. In aim 1, he will test the hypothesis that Ox neurons regulate arousal state during anesthesia
via their projections to basal forebrain (BF) and lateral habenula (LHb). In aim 2, he plans to test the hypothesis
that Ox projections to periaqueductal gray (PAG) contributes to analgesia. While manipulating neuronal activities
with optogenetic tools, the candidate will record electroencephalogram (EEG), image in vivo neural calcium
activities, and test the animal's behavior related to arousal state or pain. The proposed work will lead to the
identification of novel roles of different subsets of Ox projections in anesthesia-related arousal and pain control.
The candidate is currently an Assistant Professor in the Department of Anesthesia and Perioperative Care at the
University of California San Francisco (UCSF). His career goal is to become an independent physician scientist
dedicated to understanding the mechanisms governing anesthesia and bring patient care to the next level with
safer and more efficient anesthesia. The candidate has outstanding institutional support with 75% protected
research time, lab and office space, administrative support, and department funding for a technician and selected
equipment. UCSF is a world-class institute and the candidate has a multidisciplinary mentoring team to guide
his career development. Additionally, he has an extensive didactic plan to take advanced training in the next few
years to further build a solid foundation for his expertise in the research on the role of neural circuits in anesthesia
and analgesia.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Wei Zhou其他文献
Spin Waves Excitations of Co/PtMultilayers
Co/Pt 多层膜的自旋波激发
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
Wei Zhou - 通讯作者:
Wei Zhou
Wei Zhou的其他文献
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{{ truncateString('Wei Zhou', 18)}}的其他基金
Targeting LKB1-null lung adenocarcinoma with innate immune system
利用先天免疫系统靶向 LKB1 缺失的肺腺癌
- 批准号:
10752833 - 财政年份:2023
- 资助金额:
$ 19.91万 - 项目类别:
An integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics.
结合遗传变异、基因表达和表观遗传学的疾病基因发现的综合方法。
- 批准号:
10581608 - 财政年份:2022
- 资助金额:
$ 19.91万 - 项目类别:
An integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics.
结合遗传变异、基因表达和表观遗传学的疾病基因发现的综合方法。
- 批准号:
10349878 - 财政年份:2022
- 资助金额:
$ 19.91万 - 项目类别:
Role of orexin/hypocretin circuit in anesthesia and analgesia
食欲素/下丘脑分泌素回路在麻醉和镇痛中的作用
- 批准号:
10651642 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别:
Role of orexin/hypocretin circuit in anesthesia and analgesia
食欲素/下丘脑分泌素回路在麻醉和镇痛中的作用
- 批准号:
10430182 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别:
Role of orexin/hypocretin circuit in anesthesia and analgesia
食欲素/下丘脑分泌素回路在麻醉和镇痛中的作用
- 批准号:
10040369 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别: