Role of orexin/hypocretin circuit in anesthesia and analgesia

食欲素/下丘脑分泌素回路在麻醉和镇痛中的作用

基本信息

  • 批准号:
    10186780
  • 负责人:
  • 金额:
    $ 19.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract With the long-term research goal of advancing anesthesia through developing new tools and techniques for better anesthetic management and pain control, the candidate focuses his research on elucidating the mechanisms underlying anesthesia, in particular, the role of hypothalamic orexin (Ox) circuit in anesthesia and analgesia. How anesthetics interact with brain neural network is still poorly understood. The Ox circuit is considered to be a master regulator in sleep/wakefulness. The candidate's recent work showed that activation of Ox neurons with chemogenetic approach facilitates emergence from isoflurane anesthesia and induces analgesia. Building upon these findings, he proposes to apply optogenetics to specifically activate subsets of Ox projections to address the underlying mechanisms. The candidate started with mapping the basic neuroanatomy of the Ox projections in the mouse brain. In his preliminary work, he mapped out three-dimensional Ox projections using both confocal and lightsheet microscopy and identified three interesting regions he will focus on in this proposal. In aim 1, he will test the hypothesis that Ox neurons regulate arousal state during anesthesia via their projections to basal forebrain (BF) and lateral habenula (LHb). In aim 2, he plans to test the hypothesis that Ox projections to periaqueductal gray (PAG) contributes to analgesia. While manipulating neuronal activities with optogenetic tools, the candidate will record electroencephalogram (EEG), image in vivo neural calcium activities, and test the animal's behavior related to arousal state or pain. The proposed work will lead to the identification of novel roles of different subsets of Ox projections in anesthesia-related arousal and pain control. The candidate is currently an Assistant Professor in the Department of Anesthesia and Perioperative Care at the University of California San Francisco (UCSF). His career goal is to become an independent physician scientist dedicated to understanding the mechanisms governing anesthesia and bring patient care to the next level with safer and more efficient anesthesia. The candidate has outstanding institutional support with 75% protected research time, lab and office space, administrative support, and department funding for a technician and selected equipment. UCSF is a world-class institute and the candidate has a multidisciplinary mentoring team to guide his career development. Additionally, he has an extensive didactic plan to take advanced training in the next few years to further build a solid foundation for his expertise in the research on the role of neural circuits in anesthesia and analgesia.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Wei Zhou其他文献

Spin Waves Excitations of Co/PtMultilayers
Co/Pt 多层膜的自旋波激发

Wei Zhou的其他文献

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{{ truncateString('Wei Zhou', 18)}}的其他基金

Targeting LKB1-null lung adenocarcinoma with innate immune system
利用先天免疫系统靶向 LKB1 缺失的肺腺癌
  • 批准号:
    10752833
  • 财政年份:
    2023
  • 资助金额:
    $ 19.91万
  • 项目类别:
An integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics.
结合遗传变异、基因表达和表观遗传学的疾病基因发现的综合方法。
  • 批准号:
    10581608
  • 财政年份:
    2022
  • 资助金额:
    $ 19.91万
  • 项目类别:
An integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics.
结合遗传变异、基因表达和表观遗传学的疾病基因发现的综合方法。
  • 批准号:
    10349878
  • 财政年份:
    2022
  • 资助金额:
    $ 19.91万
  • 项目类别:
Role of orexin/hypocretin circuit in anesthesia and analgesia
食欲素/下丘脑分泌素回路在麻醉和镇痛中的作用
  • 批准号:
    10651642
  • 财政年份:
    2020
  • 资助金额:
    $ 19.91万
  • 项目类别:
Role of orexin/hypocretin circuit in anesthesia and analgesia
食欲素/下丘脑分泌素回路在麻醉和镇痛中的作用
  • 批准号:
    10430182
  • 财政年份:
    2020
  • 资助金额:
    $ 19.91万
  • 项目类别:
Role of orexin/hypocretin circuit in anesthesia and analgesia
食欲素/下丘脑分泌素回路在麻醉和镇痛中的作用
  • 批准号:
    10040369
  • 财政年份:
    2020
  • 资助金额:
    $ 19.91万
  • 项目类别:
PKC Epsilon in Vascular Dysfunction
PKC Epsilon 在血管功能障碍中的应用
  • 批准号:
    8329950
  • 财政年份:
    2012
  • 资助金额:
    $ 19.91万
  • 项目类别:
PKC Epsilon in Vascular Dysfunction
PKC Epsilon 在血管功能障碍中的应用
  • 批准号:
    8536078
  • 财政年份:
    2012
  • 资助金额:
    $ 19.91万
  • 项目类别:
PKC Epsilon in Vascular Dysfunction
PKC Epsilon 在血管功能障碍中的应用
  • 批准号:
    8698299
  • 财政年份:
    2012
  • 资助金额:
    $ 19.91万
  • 项目类别:
Pro-Oncogenic Role of LKB1 in NSCLC
LKB1 在 NSCLC 中的促癌作用
  • 批准号:
    8830435
  • 财政年份:
    2011
  • 资助金额:
    $ 19.91万
  • 项目类别:
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