Youth-GEMs: Gene Environment interactions in Mental health trajectories of Youth

青年-GEM：青年心理健康轨迹中的基因环境相互作用

• 批准号: 10038026
• 金额: $ 90.05万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10038026
• 关键词: Youth; GEMs; Gene; Environment; interactions

Youth mental health is heavily burdened, with life-long enduring impact on European citizens and societies. Trajectories of mental health and illness in young people are assumed to be determined by interplay between genetic, epigenetic, and environmental risk impacting during development. However, direct evidence for this is sparse and scientific progress is challenged. We recently initiated substantial advances enabling us to create necessary breakthroughs at the most pressing needs and challenges. Aiming to significantly reduce mentalsuffering and illness among European youth within the next 5-10 years, we will provide 1) the world?sfirst, evidence-based knowledge base of functional (epi)genomics of the developing post-natal human brain in direct relation to developmental trajectories of trans-syndromal phenotypes of mental illness, providing improved risk markers and actionable biological targets, 2) reliable predictive models, while identifying gene-environment interplay, as well as actionable markers of trajectories of mental (ill)health in young people through the use of Artificial Intelligence (AI)-based and inference-based analyses of unprecedented sets of longitudinal general population datasets, 3) the first comprehensive, validated set of evidence-based behavioural, environmental, biological, and psychological-informed instruments for the robust quantitative clinical assessment of mental health for help-seeking young people aged 12-24 years, harmonised across European clinical settings, and 4) youth- and clinician-empowering AI-driven instruments for early (self)detection, prediction and monitoring of mental ill-health trajectories in youth. Our multidisciplinary consortium is uniquely equipped and positioned to enforce the necessary breakthroughs for significant reduction of mental illness and suffering of young people, and to translate our findings into clinical innovation and life-long impact in Europe and beyond.

青年心理健康负担沉重，对欧洲公民和社会产生了终身持久的影响。年轻人的心理健康和疾病的轨迹被认为是由发育过程中影响的遗传、表观遗传和环境风险之间的相互作用决定的。然而，这方面的直接证据很少，科学进步也受到了挑战。我们最近取得了重大进展，使我们能够在最紧迫的需求和挑战中取得必要的突破。为了在未来5-10年内显著减少欧洲青年的心理痛苦和疾病，我们将提供1)世界上第一个基于证据的知识库--出生后发育中的人脑功能(EPI)基因组学与跨综合征精神疾病表型的发育轨迹直接相关的循证知识库，提供改进的风险标记物和可操作的生物靶标，2)可靠的预测模型，同时通过使用基于人工智能(AI)和基于推理的史无前例的纵向一般人口数据集的分析，识别基因-环境相互作用以及年轻人心理(疾病)健康轨迹的可操作标记物，3)第一个全面的，经过验证的一套基于证据的行为、环境、生物和心理信息工具，用于对12-24岁寻求帮助的年轻人的心理健康进行强有力的量化临床评估，在整个欧洲临床环境中协调一致，以及4)青年和临床医生驱动的人工智能工具，用于早期(自我)检测、预测和监测青年的精神疾病轨迹。我们的多学科联盟拥有独特的设备和地位，可以实施必要的突破，显著减少年轻人的精神疾病和痛苦，并将我们的发现转化为欧洲和其他地区的临床创新和终身影响。