Translational Immunology Training Program

项目摘要/摘要 这是一个经过修订的竞争性续订T32应用程序，其中我们合并并重新配置了两个 西奈山伊坎医学院(ISMMS)以前独特而成功的T32项目，a 移植免疫学博士后课程[(P Heeger，前项目主任(PD)]和博士后/博士后 免疫学计划(S·利拉，前PD)，在#年扩大了博士后和博士后培训计划 翻译免疫学(P Heeger和S Lira共同发表)。将这些计划合并将a)增强 通过交叉受精(如暴露)进行的翻译免疫学培训(包括移植培训) 癌症免疫学实习生通过联合移植免疫学、免疫缺陷和自身免疫 培训地点)b)利用共同的培训人员和机构资源，以及经修订的 注重免疫学的行政基础设施(包括教育、职业发展和评估 进程)以增强培训体验的功能和效率，以及c)限制培训之间的重叠 教职员工。其他理由包括1)我们在过去16年中在吸引和培训Pre-And 进入免疫学研究职业的博士后医学博士、博士和医学/博士实习生，2)继续需要 改善免疫介导性疾病的结果3)我们希望对未来的教育产生积极影响 免疫学的基础和翻译研究人员，以及4)我们的培训环境和研究 FOCUS非常适合为学员提供多样化的基础和翻译免疫学研究机会。这个 西奈山免疫学社区做出根本性发现的非凡能力，将 结果纳入新的和有效的诊断和治疗策略，并纳入博士前后 将培训纳入其研究任务强调了修订后的培训计划的重要性。整体而言 该项目的目标是吸引和培养2年以上的医学博士、博士和博士后 在与人类疾病相关的免疫学领域取得成功、独立的职业生涯的时期。我们有一个多样化的， 资金雄厚，对免疫学有广泛兴趣的教师，以及强大的博士后和博士后实习生队伍， 包括相当数量的代表不足的少数群体。该计划旨在通过以下方式提供培训 个人导师，从事与人类疾病相关的免疫学各个方面的研究。该计划 得到强有力的监督和管理结构的支持，在免疫学方面进行重要的教学培训， 科学写作和职业发展，并包含新增加的最先进的评估方法 有明确的目标和成功的基准，以优化自主学术的发展 该领域的研究人员。

Project Summary/Abstract This is a revised, competitive renewal, T32 application in which we have coalesced and reconfigured two previously distinct and successful T32 programs at the Icahn School of Medicine at Mount Sinai (ISMMS), a post-doc program in Transplant Immunology [(P Heeger, former program director (PD)] and a pre-/post-doc program in Immunology (S Lira, former PD), into an expanded pre- and post-doctoral training program in Translational Immunology (P Heeger and S Lira Co-PDs). Combining the programs will a) enhance translational immunology training (including training in transplantation) through cross fertilization (e.g. exposing trainees in cancer immunology to transplant immunology, immunodeficiency and autoimmunity through a joint training venue) b) leverage common training faculty and institutional resources, as well as a revised immunology-focused, administrative infrastructure (including education, career development and evaluation processes) to enhance function and efficiency of the training experience, and c) limit overlap among training faculty. Additional rationale include 1) our success over the past 16 years in attracting and training pre- and post-doctoral MD, PhD and MD/PhD trainees into immunology research careers, 2) the continued need for improving outcomes of immune-mediated diseases 3) our desire to positively impact the education of future basic and translational investigators in immunology, and 4) the fact that our training environment and research foci are well-suited to offer diverse basic and translational immunology research opportunities for trainees. The exceptional ability of Mount Sinai's immunology community to make fundamental discoveries, to translate the results into novel and effective diagnostic and therapeutic strategies, and to incorporate pre- and post-doc training into its research mission underscores the significance of this revised training program. The overall objective of this program is to attract and train talented MD/PhD and PhD students and post-docs over 2 year periods, for successful, independent careers in immunology relevant to human disease. We have a diverse, well-funded faculty with broad interest in immunology and a strong pool of pre- and post-doc trainees that includes significant numbers of underrepresented minorities. The program is designed to provide training by individual mentors performing research in all aspects of Immunology relevant to human disease. The program is supported with strong oversight and administrative structure, significant didactic training in Immunology, scientific writing and career development, and contains newly added state of the art evaluation approaches with defined goals and benchmarks for success so as to optimize the development of independent academic researchers in the field.