Cross-disciplinary Postdoctoral Training Program in Transplant Research

移植研究跨学科博士后培养项目

• 批准号: 7502971
• 负责人: Peter Scott Heeger
• 金额: $ 6.42万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7502971
• 关键词: Research; Training Programs; Transplantation; post-doctoral training

DESCRIPTION (provided by applicant): Solid organ transplantation is the ideal therapy for end stage organ failure including kidney, heart, liver, lung, islet and small bowel. Despite significant improvements in the care of all solid organ transplant recipients and in outcomes following bone marrow transplantation, long term allograft survival remains suboptimal, causes of graft loss and graft vs. host disease are only partially understood, reliable tolerance induction protocols remain elusive, and the ability to translate what information is available into useful diagnostic, preventive and treatment modalities has been limited. In order to continue to improve transplant outcomes in humans and as a consequence, improve the long term health of all transplant recipients, research in transplantation must remain cutting edge, and the next generation of M.D. and Ph.D. physicians/scientists must have the appropriate skills to continue to drive the field forward. Thus, the objective of this institutional postdoctoral T32 application is to use an interactive, collaborative, cross-disciplinary approach to train talented physician-scientists (M.D. and M.D. Ph.D.) or Ph.D.-scientists for successful independent careers in investigative transplantation research. An experienced and well funded group of 20 trainers from a host of departments within the Mt. Sinai School of Medicine, an institution dedicated to supporting basic and translational science, will provide postdoctoral fellows with the opportunity to train in a variety of areas of research related to transplantation. Postdoctoral trainees currently holding a degree of M.D., Ph.D., or M.D. / Ph.D. will be selected for support based on having outstanding potential to pursue a research career and a commitment to independent investigation. Support is requested for 1 postdoctoral trainee in year 1, 2 in year 2 and 3 in years 3-5 of the training application. Training will require a minimum of 2 years. Trainees will participate in an interactive environment with state of the art shared research facilities, involving required courses, a core transplant science seminar series, journal clubs, and laboratory meetings. An internal advisory board will assure that the highest quality applicants will perform transplant oriented research with qualified trainers. The advisory board and an external review group will supplement trainer supervision to ensure that that the program remains cutting edge and that trainees receive sufficient guidance to optimize their transition to independent investigators in transplantation, a field directly relevant to human health.

描述（由申请人提供）：实体器官移植是终末期器官衰竭的理想治疗方法，包括肾、心脏、肝、肺、胰岛和小肠。尽管所有实体器官移植受者的护理和骨髓移植后的结果有了显著改善，但长期同种异体移植物存活率仍然不理想，移植物丢失和移植物抗宿主病的原因仅部分了解，可靠的耐受诱导方案仍然难以捉摸，并且将可用信息转化为有用的诊断、预防和治疗方式的能力有限。为了继续改善人类移植结果，并因此改善所有移植受者的长期健康，移植研究必须保持领先地位，下一代医学博士和博士医生/科学家必须具备适当的技能，以继续推动该领域的发展。因此，这个机构的博士后T32应用程序的目标是使用互动，协作，跨学科的方法来培养有才华的医生，科学家（医学博士）。和医学博士博士）或博士学位-科学家成功的独立职业调查移植研究。一个经验丰富、资金充足的20名培训员小组，来自山区各部门。西奈医学院是一家致力于支持基础和转化科学的机构，将为博士后研究员提供在与移植相关的各种研究领域进行培训的机会。目前持有医学博士学位的博士后学员，哲学博士、或者医学博士/博士将根据具有从事研究事业的杰出潜力和对独立调查的承诺来选择支持。在培训申请的第一年，要求为1名博士后培训生提供支持，第二年为2名，第三年至第五年为3名。培训至少需要两年。学员将参加一个互动的环境与最先进的共享研究设施，涉及必修课程，核心移植科学研讨会系列，期刊俱乐部和实验室会议。一个内部咨询委员会将确保最高质量的申请人将与合格的培训师一起进行移植导向的研究。顾问委员会和外部审查小组将补充培训师的监督，以确保该计划保持领先地位，并确保受训人员获得足够的指导，以优化他们向移植独立研究人员的过渡，这是一个与人类健康直接相关的领域。