Cross-disciplinary Postdoctoral Training Program in Transplant Research

描述（申请人提供）：实体器官移植是治疗肾、心、肝、肺、胰岛、小肠等终末期器官衰竭的理想方法。尽管所有实体器官移植受者的护理和骨髓移植后的结果有了显著的改善，但同种异体移植的长期存活仍然不是最理想的，移植物损失和移植物抗宿主病的原因仅部分了解，可靠的耐受性诱导方案仍然难以捉摸，并且将现有信息转化为有用的诊断、预防和治疗方式的能力有限。为了继续改善人类的移植结果，从而改善所有移植接受者的长期健康，移植研究必须保持前沿，下一代医学博士和博士医生/科学家必须具备适当的技能继续推动该领域向前发展。因此，这个机构博士后T32申请的目标是使用互动，协作，跨学科的方法来培养有才华的内科科学家（医学博士和医学博士）或博士科学家，使他们在研究性移植研究中获得成功的独立职业生涯。西奈山医学院是一个致力于支持基础科学和转化科学的机构，由来自西奈山医学院多个部门的20名经验丰富、资金充足的培训师组成的团队，将为博士后提供在与移植相关的各种研究领域进行培训的机会。目前持有医学博士、博士或医学博士/博士学位的博士后学员，将根据其从事研究事业的突出潜力和对独立研究的承诺，被选择支持。在培训申请的第1年有1名博士后实习生，第2年有2名，第3-5年有3名。培训至少需要2年。受训者将参与一个互动的环境，与最先进的共享研究设施，包括必修课程，核心移植科学系列研讨会，期刊俱乐部和实验室会议。一个内部咨询委员会将确保最高质量的申请人将与合格的培训师进行移植导向的研究。咨询委员会和一个外部审查小组将补充对培训人员的监督，以确保该方案保持领先地位，并确保受训者得到充分指导，以优化他们向移植领域独立调查员的过渡，这是一个与人类健康直接相关的领域。

DESCRIPTION (provided by applicant): Solid organ transplantation is the ideal therapy for end stage organ failure including kidney, heart, liver, lung, islet and small bowel. Despite significant improvements in the care of all solid organ transplant recipients and in outcomes following bone marrow transplantation, long term allograft survival remains suboptimal, causes of graft loss and graft vs. host disease are only partially understood, reliable tolerance induction protocols remain elusive, and the ability to translate what information is available into useful diagnostic, preventive and treatment modalities has been limited. In order to continue to improve transplant outcomes in humans and as a consequence, improve the long term health of all transplant recipients, research in transplantation must remain cutting edge, and the next generation of M.D. and Ph.D. physicians/scientists must have the appropriate skills to continue to drive the field forward. Thus, the objective of this institutional postdoctoral T32 application is to use an interactive, collaborative, cross-disciplinary approach to train talented physician-scientists (M.D. and M.D. Ph.D.) or Ph.D.-scientists for successful independent careers in investigative transplantation research. An experienced and well funded group of 20 trainers from a host of departments within the Mt. Sinai School of Medicine, an institution dedicated to supporting basic and translational science, will provide postdoctoral fellows with the opportunity to train in a variety of areas of research related to transplantation. Postdoctoral trainees currently holding a degree of M.D., Ph.D., or M.D. / Ph.D. will be selected for support based on having outstanding potential to pursue a research career and a commitment to independent investigation. Support is requested for 1 postdoctoral trainee in year 1, 2 in year 2 and 3 in years 3-5 of the training application. Training will require a minimum of 2 years. Trainees will participate in an interactive environment with state of the art shared research facilities, involving required courses, a core transplant science seminar series, journal clubs, and laboratory meetings. An internal advisory board will assure that the highest quality applicants will perform transplant oriented research with qualified trainers. The advisory board and an external review group will supplement trainer supervision to ensure that that the program remains cutting edge and that trainees receive sufficient guidance to optimize their transition to independent investigators in transplantation, a field directly relevant to human health.