Cross-Disciplinary Training Program in Transplant Research

移植研究跨学科培训计划

• 批准号: 9284372
• 负责人: Peter Scott Heeger
• 金额: $ 18.06万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9284372
• 关键词: Research; Training Programs; Transplantation

DESCRIPTION (provided by applicant): This is a competing renewal application for a postdoctoral T32 training grant in laboratory-based transplantation biology. Solid organ transplantation is the ideal therapy for end stage failure due to kidney, heart, liver, and lung, disease, among other organs. Despite significant improvements in the care of all solid organ transplant recipients long term allograft survival remains suboptimal. Analogously, bone marrow transplantation is an effective therapy for hematologic malignancies, but acute (and chronic) graft versus host disease occurs commonly and causes significant morbidity. Moreover, while scientific progress has increased knowledge, the causes of graft loss (and GVHD) are only partially understood, reliable tolerance induction protocols remain elusive, and the ability to translate what information is available into useful diagnostic, preventive and treatment modalities in patients has been limited. To continue to improve transplant outcomes in humans and as a consequence, improve the long term health of all transplant recipients, research in transplantation must remain cutting edge, and the next generation of physicians/scientists must have the appropriate knowledge base and skills to continue to drive the field forward. Because transplantation is a cross disciplinary field involving multiple medical, surgical, and basic pathology/immunology themes, we believe an effective training environment must be cross-disciplinary. Thus, the objective of this training program is to use an interactive, collaborative, cross-disciplinary approach to train talented young physician-scientists (MD and MD PhD) or PhD-scientists for a successful career in laboratory based, investigative, transplantation immunobiology research. In support of the renewal application, the initial funding period of this training program has been successful in accomplishing the key aim of fostering the careers of trainees in transplantation, in particular, underrepresented minorities. Our rationales for submitting this competitive renewal grant application include: 1) the continued need for improving outcomes following solid organ or hematopoietic cell transplantation, 2) our strong desire to continue to have an impact on the education of future investigators in the field of transplantation, and 3) our belief that the proposed group of trainers will offer diverse basic and translational scientific opportunities within the field of transplantation supported by an established infrastructure designed for training and nurturing young transplant researchers toward independence. We have a diverse and well funded faculty with an interest in transplantation and a strong pool of trainees that includes significant numbers of underrepresented minorities. The program is overseen by P Heeger, who is well recognized and accomplished clinical and basic physician scientist with significant postdoctoral training, and educational, experience. The program is designed to support laboratory based training by individual mentors performing research in transplantation medicine/biology. The cross disciplinary program is supplemented with significant didactic training in transplantation science, grant writing, manuscript preparation and career development so as to optimize the development of independent academic researchers in the transplant field.

描述（由申请人提供）：这是基于实验室的移植生物学中的博士后T32培训补助金的竞争续订申请。固体器官移植是由于肾脏，心脏，肝脏和肺，疾病等机构而导致的终端阶段衰竭的理想疗法。尽管所有固体器官移植受者的护理显着改善了长期同种异体移植的存活率，但仍然是最佳的。类似地，骨髓移植是血液学恶性肿瘤的有效疗法，但是急性（和慢性）移植物与宿主疾病通常发生，并引起明显的发病率。此外，尽管科学进步的知识增加，但仅了解移植物损失（和GVHD）的原因，但可靠的耐受性诱导方案仍然难以捉摸，并且能够将可用信息转化为患者的有用诊断，预防和治疗方式的能力受到限制。为了继续改善人类的移植结局，因此，改善所有移植接受者的长期健康状况，移植研究必须保持最前沿，下一代医师/科学家必须具有适当的知识库和技能，以继续推动该领域前进。由于移植是一个跨学科领域，涉及多种医学，外科和基本的病理/免疫学主题，因此我们认为有效的培训环境必须是跨学科的。因此，该培训计划的目的是使用互动，协作， 训练有才华的年轻医师科学家（MD和MD博士学位）或博士学位科学家的跨学科方法，从事实验室，调查，移植免疫生物学研究的成功职业。为了支持续订申请，该培训计划的初始资金期限已成功完成了培养受训者的移植职业，特别是代表性少数群体的关键目的。我们提交此竞争性更新赠款申请的理由包括：1）在固体器官或造血细胞移植后，持续改善结果的持续需求，2）我们强烈希望继续对移植领域的未来调查人员的教育以及3）我们的信念，我们的信念将为我们提供多样化的基本培训者团体，以提供各种各样的研究人员。 在移植领域内的转化科学机会由旨在培训和培养年轻移植研究人员迈向独立的既定基础设施支持。我们有一个多元化且资助丰富的教职员工，对移植感兴趣，并且有强大的学员库，其中包括大量代表性不足的少数民族。该计划由P Heeger监督，P Heeger受到了丰富的临床和基础医师的认可和成就，并具有重大的博士后培训以及教育，经验。该计划旨在支持进行移植医学/生物学研究的个人导师的基于实验室的培训。跨学科计划补充了移植科学中的重大教学培训， 授予写作，手稿准备和职业发展，以优化移植领域独立学术研究人员的发展。